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1.
Evaluating the palliative care workforce in Southern California: a conversation.
McNeal, Helen B; Mack, George; Slininger, Julia; Yates, Judith; Alexiou, Dimitrios.
J Palliat Med ; 16(9): 1115-7, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23849003

Subject(s)
Palliative Care , California , Female , Humans , Male , Needs Assessment , Organizational Objectives , Total Quality Management , Workforce
2.
Goodbye, post-acute care. 'Heavy-lifting' will shift to community-based care.
Nahm, Steve; Mack, George.
Mod Healthc ; 43(3): 26, 2013 Jan 21.
Article in English | MEDLINE | ID: mdl-23487978

Subject(s)
Continuity of Patient Care/economics , Home Care Services/economics , Medicare/economics , Aged , Continuity of Patient Care/standards , Continuity of Patient Care/trends , Home Care Services/standards , Home Care Services/trends , Humans , Medicare/standards , Medicare/trends , Patient Discharge/economics , Patient Discharge/standards , Patient Discharge/trends , Telemedicine/economics , Telemedicine/standards , Telemedicine/trends , United States
3.
ReNeuron and StemCells get green light for neural stem cell trials.
Mack, George S.
Nat Biotechnol ; 29(2): 95-7, 2011 Feb.
Article in English | MEDLINE | ID: mdl-21301419

Subject(s)
Neural Stem Cells/physiology , Stem Cell Transplantation/methods , Biotechnology , Brain Diseases/surgery , Clinical Trials as Topic , Drug Industry , Genetic Engineering , Humans , Paraplegia/surgery , Stroke/surgery , United Kingdom , United States
4.
To selectivity and beyond.
Mack, George S.
Nat Biotechnol ; 28(12): 1259-66, 2010 Dec.
Article in English | MEDLINE | ID: mdl-21139608

Subject(s)
Biological Therapy/methods , Drug Discovery/methods , Drug Industry/methods , Epigenesis, Genetic , Animals , Humans
5.
Lost in migration.
Mack, George S; Marshall, Andrew.
Nat Biotechnol ; 28(3): 214-29, 2010 Mar.
Article in English | MEDLINE | ID: mdl-20212481

Subject(s)
Neoplasms/pathology , Neoplasms/therapy , Animals , Cell Hypoxia , Cell Movement/physiology , Disease Models, Animal , Drug Delivery Systems/methods , Humans , Intercellular Signaling Peptides and Proteins/metabolism , Mice , Neoplasm Metastasis , Neoplasm Transplantation , Neoplasms/metabolism , Neoplastic Stem Cells , Signal Transduction , Whole Body Imaging
6.
Expanded access rules pose quandary for drug developers.
Mack, George S.
Nat Biotechnol ; 27(10): 871-2, 2009 Oct.
Article in English | MEDLINE | ID: mdl-19816423

Subject(s)
Compassionate Use Trials/legislation & jurisprudence , Drug Industry/legislation & jurisprudence , United States Food and Drug Administration/legislation & jurisprudence , Drugs, Investigational , Humans , United States
7.
Mixed news for Avastin.
Mack, George S.
Nat Biotechnol ; 27(6): 494, 2009 Jun.
Article in English | MEDLINE | ID: mdl-19513035

Subject(s)
Angiogenesis Inhibitors/therapeutic use , Antibodies, Monoclonal/therapeutic use , Antineoplastic Agents/therapeutic use , Colonic Neoplasms/drug therapy , Drug Industry , Antibodies, Monoclonal, Humanized , Bevacizumab , Clinical Trials, Phase III as Topic , Drug Industry/economics , Drug Industry/trends , Glioblastoma/drug therapy , Humans , Vascular Endothelial Growth Factor A/antagonists & inhibitors
8.
Osiris seals billion-dollar deal with Genzyme for cell therapy.
Mack, George S.
Nat Biotechnol ; 27(2): 106-7, 2009 Feb.
Article in English | MEDLINE | ID: mdl-19204671

Subject(s)
Biotechnology , Cell- and Tissue-Based Therapy , Health Care Sector , Adult , Child , Humans , Mesenchymal Stem Cells
9.
FDA holds court on post hoc data linking KRAS status to drug response.
Mack, George S.
Nat Biotechnol ; 27(2): 110-2, 2009 Feb.
Article in English | MEDLINE | ID: mdl-19204679

Subject(s)
Antineoplastic Agents/therapeutic use , Colorectal Neoplasms/drug therapy , Genes, ras , Mutation , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal, Humanized , Biomarkers, Tumor/genetics , Cetuximab , Clinical Trials as Topic , Colorectal Neoplasms/genetics , Panitumumab , Proto-Oncogene Proteins/genetics , Proto-Oncogene Proteins p21(ras) , United States , United States Food and Drug Administration , ras Proteins/genetics
10.
Alan Alda.
Mack, George S.
Nat Biotechnol ; 26(12): 1325, 2008 Dec.
Article in English | MEDLINE | ID: mdl-19060860

Subject(s)
Famous Persons , Science/education , Television , Drama/history , History, 20th Century , History, 21st Century , Information Dissemination , Television/history , United States
11.
CD20 blockers eye crowded rheumatology market.
Mack, George S.
Nat Biotechnol ; 26(10): 1053-4, 2008 Oct.
Article in English | MEDLINE | ID: mdl-18846053

Subject(s)
Antibodies, Monoclonal/economics , Antibodies, Monoclonal/therapeutic use , Antigens, CD20/drug effects , Arthritis, Rheumatoid/drug therapy , Drug Industry/economics , Marketing/economics , Antibodies, Monoclonal, Humanized , Arthritis, Rheumatoid/economics , Drug Design , Drug Industry/trends , Humans , Marketing/trends , Rheumatology/economics , Rheumatology/trends , United States
12.
Pharmas partner in venture seeking drug discovery tools.
Mack, George S.
Nat Biotechnol ; 26(9): 960-1, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18779790

Subject(s)
Biotechnology/trends , Drug Industry/trends , Biotechnology/economics , Capital Financing , Commerce , Drug Design , Drug Industry/economics , Humans , Investments/economics
13.
Profile: Julian Davies.
Mack, George S.
Nat Biotechnol ; 26(7): 727, 2008 Jul.
Article in English | MEDLINE | ID: mdl-18612285

Subject(s)
Biotechnology/history , Genomics/history , Microbiology/history , Europe , History, 20th Century , History, 21st Century , United States
14.
FDA balks at Myozyme scale-up.
Mack, George.
Nat Biotechnol ; 26(6): 592, 2008 Jun.
Article in English | MEDLINE | ID: mdl-18536660

Subject(s)
Drug Approval , Drug Industry/trends , Glycogen Storage Disease Type II/drug therapy , alpha-Glucosidases/therapeutic use , Humans
15.
Genzyme and Isis strike megadeal.
Mack, George S.
Nat Biotechnol ; 26(3): 251-3, 2008 Mar.
Article in English | MEDLINE | ID: mdl-18327216

Subject(s)
Biotechnology/economics , Biotechnology/organization & administration , Drug Industry/economics , Drug Industry/organization & administration , Commerce , Economic Competition , Marketing
16.
Pfizer dumps Exubera.
Mack, George S.
Nat Biotechnol ; 25(12): 1331-2, 2007 Dec.
Article in English | MEDLINE | ID: mdl-18066009

Subject(s)
Consumer Behavior/economics , Diabetes Mellitus/drug therapy , Diabetes Mellitus/economics , Drug Industry/economics , Drug Industry/trends , Insulin/administration & dosage , Insulin/economics , Administration, Inhalation , Humans , Marketing , Nebulizers and Vaporizers , United States
17.
MicroRNA gets down to business.
Mack, George S.
Nat Biotechnol ; 25(6): 631-8, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17557095

Subject(s)
Drug Industry/trends , Gene Silencing , Gene Targeting/trends , Genetic Therapy/trends , MicroRNAs/drug effects , MicroRNAs/genetics
18.
Big pharma wants you.
Mack, George S.
Nat Biotechnol ; 24(11): 1317-9, 2006 Nov.
Article in English | MEDLINE | ID: mdl-17162751

ABSTRACT

There's another kind of venture capitalist lurking in the corridors of capital.


Subject(s)
Biotechnology/economics , Drug Industry/economics , Entrepreneurship/economics , Investments/economics , Capital Financing , Commerce/economics , Intellectual Property , United States
19.
Epigenetic cancer therapy makes headway.
Mack, George S.
J Natl Cancer Inst ; 98(20): 1443-4, 2006 Oct 18.
Article in English | MEDLINE | ID: mdl-17047192

Subject(s)
Antineoplastic Agents/pharmacology , Antineoplastic Agents/therapeutic use , Epigenesis, Genetic/drug effects , Gene Expression Regulation, Neoplastic/drug effects , Neoplasms/drug therapy , Acetylation/drug effects , Animals , Antineoplastic Agents/administration & dosage , Azacitidine/analogs & derivatives , Azacitidine/pharmacology , DNA Methylation/drug effects , Decitabine , Histone Deacetylases/pharmacology , Humans , Hydroxamic Acids/pharmacology , Methyltransferases/pharmacology , Neoplasms/genetics , Randomized Controlled Trials as Topic , Valproic Acid/pharmacology , Vorinostat
20.
Ariad Pharmaceuticals wins first round over Eli Lilly, patents on methods can be far-reaching.
Mack, George S.
J Natl Cancer Inst ; 98(15): 1028-30, 2006 Aug 02.
Article in English | MEDLINE | ID: mdl-16882935

Subject(s)
Drug Industry/legislation & jurisprudence , NF-kappa B , Patents as Topic/legislation & jurisprudence , Antibodies, Monoclonal/pharmacology , Antibodies, Monoclonal, Murine-Derived , Biotechnology/legislation & jurisprudence , Boronic Acids/pharmacology , Bortezomib , Celecoxib , Cyanides/pharmacology , Drug Industry/economics , Etanercept , Guanidines/pharmacology , Humans , Immunoglobulin G/pharmacology , Interleukin 1 Receptor Antagonist Protein , NF-kappa B/drug effects , NF-kappa B/metabolism , Protein C/pharmacology , Pyrazines/pharmacology , Pyrazoles/pharmacology , Raloxifene Hydrochloride/pharmacology , Receptors, Tumor Necrosis Factor , Recombinant Proteins/pharmacology , Rituximab , Sialoglycoproteins/pharmacology , Sulfonamides/pharmacology , United States
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