Iodine status of Indigenous and non-Indigenous young adults in the Top End, before and after mandatory fortification.

OBJECTIVE: To assess the median urine iodine concentration (UIC) of young adults in the Top End of Northern Territory, before and after fortification of bread with iodised salt became mandatory. DESIGN, SETTING: Analysis of cross-sectional data from two longitudinal studies, the Aboriginal Birth Cohort and the non-Indigenous Top End Cohort, pre- (Indigenous participants: 2006-2007; non-Indigenous participants: 2007-2009) and post-fortification (2013-15). PARTICIPANTS: Indigenous and non-Indigenous Australian young adults (mean age: pre-fortification, 17.9 years (standard deviation [SD], 1.20 years); post-fortification, 24.9 years (SD, 1.34 years). MAIN OUTCOME MEASURE: Median UIC (spot urine samples analysed by a reference laboratory), by Indigenous status, remoteness of residence, and sex. RESULTS: Among the 368 participants assessed both pre- and post-fortification, the median UIC increased from 58 µg/L (interquartile range [IQR], 35-83 µg/L) pre-fortification to 101 µg/L (IQR, 66-163 µg/L) post-fortification (P < 0.001). Urban Indigenous (median IUC, 127 µg/L; IQR, 94-203 µg/L) and non-Indigenous adults (117 µg/L; IQR, 65-160 µg/L) were both iodine-replete post-fortification. The median UIC of remote Indigenous residents increased from 53 µg/L (IQR, 28-75 µg/L) to 94 µg/L (IQR, 63-152 µg/L; p < 0.001); that is, still mildly iodine-deficient. The pre-fortification median UIC for 22 pregnant women was 48 µg/L (IQR, 36-67 µg/L), the post-fortification median UIC for 24 pregnant women 93 µg/L (IQR, 62-171 µg/L); both values were considerably lower than the recommended minimum of 150 µg/L for pregnant women. CONCLUSIONS: The median UIC of young NT adults increased following mandatory fortification of bread with iodised salt. The median UIC of pregnant Indigenous women in remote locations, however, remains low, and targeted interventions are needed to ensure healthy fetal development.

Haematocrit levels and anaemia in Australian children aged 1-4 years.

The aim of this study was to describe the prevalence of anaemia, mean haematocrit levels, and the risk factors influencing haematocrit in participants of the 1995 National Survey of Lead in Children. A nationally-representative cross-sectional survey of children aged 1-4 years inclusive was done. Mean haematocrit and the proportion with anaemia using both the US and WHO haematocrit-based criteria were calculated. Multivariate regression was used to identify factors associated with haematocrit. Mean haematocrit level was 38.8% (95% CI: 38.6 - 39.1%) and varied with age of child, state/territory of residence and whether the child was taking supplements. It did not vary by sex, Aboriginal identification, maternal birthplace, whether the child ate meat or any other selected characteristic. The factors identified explained only 4% of the variation in haematocrit levels. The prevalence of anaemia was 3.3% (95% CI: 2.4 - 4.5%) based on the US criteria and 2.0% (95% CI: 1.3 - 3.1%) based on the WHO criteria. The prevalence of anaemia in this national survey was lower than the prevalence of iron deficiency anaemia reported in several more localised studies.