Stimulus valence moderates self-learning.

Self-relevance has been demonstrated to impair instrumental learning. Compared to unfamiliar symbols associated with a friend, analogous stimuli linked with the self are learned more slowly. What is not yet understood, however, is whether this effect extends beyond arbitrary stimuli to material with intrinsically meaningful properties. Take, for example, stimulus valence an established moderator of self-bias. Does the desirability of to-be-learned material influence self-learning? Here, in conjunction with computational modelling (i.e. Reinforcement Learning Drift Diffusion Model analysis), a probabilistic selection task was used to establish if and how stimulus valence (i.e. desirable/undesirable posters) impacts the acquisition of knowledge relating to object-ownership (i.e. owned-by-self vs. owned-by-friend). Several interesting results were observed. First, undesirable posters were learned more rapidly for self compared to friend, an effect that was reversed for desirable posters. Second, learning rates were accompanied by associated differences in reward sensitivity toward desirable and undesirable choice selections as a function of ownership. Third, decisional caution was greater for self-relevant (vs. friend relevant) responses. Collectively, these findings inform understanding of self-function and how valence and stimulus relevance mutually influence probabilistic learning.

Learning about me and you: Only deterministic stimulus associations elicit self-prioritization.

Self-relevant material has been shown to be prioritized over stimuli relating to others (e.g., friend, stranger), generating benefits in attention, memory, and decision-making. What is not yet understood, however, is whether the conditions under which self-related knowledge is acquired impacts the emergence of self-bias. To address this matter, here we used an associative-learning paradigm in combination with a stimulus-classification task to explore the effects of different learning experiences (i.e., deterministic vs. probabilistic) on self-prioritization. The results revealed an effect of prior learning on task performance, with self-prioritization only emerging when participants acquired target-related associations (i.e., self vs. friend) under conditions of certainty (vs. uncertainty). A further computational (i.e., drift diffusion model) analysis indicated that differences in the efficiency of stimulus processing (i.e., rate of information uptake) underpinned this self-prioritization effect. The implications of these findings for accounts of self-function are considered.

Facial first impressions are not mandatory: A priming investigation.

A common assertion is that, based around prominent character traits, first impressions are spontaneously extracted from faces. Specifically, mere exposure to a person is sufficient to trigger the involuntary extraction of core personality characteristics (e.g., trustworthiness, dominance, competence), an outcome that supports a range of significant judgments (e.g., hiring, investing, electing). But is this in fact the case? Noting ambiguities in the extant literature, here we used a repetition priming procedure to probe the extent to which impressions of dominance are extracted from faces absent the instruction to evaluate the stimuli in this way. Across five experiments in which either the character trait of interest was made increasingly obvious to participants (Expts. 1-3) or attention was explicitly directed toward the faces to generate low-level/high-level judgments (Expts. 4 & 5), no evidence for the spontaneous extraction of first impressions was observed. Instead, priming only emerged when judgments of dominance were an explicit requirement of the task at hand. Thus, at least using a priming methodology, the current findings contest the notion that first impressions are a mandatory product of person perception.

Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice.

Diminished insulin and insulin-like growth factor-1 signaling extends the lifespan of invertebrates1-4; however, whether it is a feasible longevity target in mammals is less clear5-12. Clinically utilized therapeutics that target this pathway, such as small-molecule inhibitors of phosphoinositide 3-kinase p110α (PI3Ki), provide a translatable approach to studying the impact of these pathways on aging. Here, we provide evidence that dietary supplementation with the PI3Ki alpelisib from middle age extends the median and maximal lifespan of mice, an effect that was more pronounced in females. While long-term PI3Ki treatment was well tolerated and led to greater strength and balance, negative impacts on common human aging markers, including reductions in bone mass and mild hyperglycemia, were also evident. These results suggest that while pharmacological suppression of insulin receptor (IR)/insulin-like growth factor receptor (IGFR) targets could represent a promising approach to delaying some aspects of aging, caution should be taken in translation to humans.

Engineered mineralogical interfaces as radionuclide repositories.

Effective capture of fugitive actinides and daughter radionuclides constitutes a major remediation challenge at legacy or nuclear accident sites globally. The ability of double-layered, anionic clay minerals known as hydrotalcites (HTC) to contemporaneously sequester a range of contaminants from solution offers a unique remedy. However, HTC do not provide a robust repository for actinide isolation over the long term. In this study, we formed HTC by in-situ precipitation in a barren lixiviant from a uranium mine and thermally transformed the resulting radionuclide-laden, nanoscale HTC. Atomic-scale forensic examination of the amorphized/recrystallised product reveals segregation of U to nanometre-wide mineral interfaces and the local formation of interface-hosted mineral grains. This U-phase is enriched in rare earth elements, a geochemical analogue of actinides such as Np and Pu, and represents a previously unreported radionuclide interfacial segregation. U-rich phases associated with the mineral interfaces record a U concentration factor of ~ 50,000 relative to the original solute demonstrating high extraction and concentration efficiencies. In addition, the co-existing host mineral suite of periclase, spinel-, and olivine-group minerals that equate to a lower mantle, high P-T mineral assemblage have geochemical and geotechnical properties suitable for disposal in a nuclear waste repository. Our results record the efficient sequestering of radionuclides from contaminated water and this novel, broad-spectrum, nanoscale HTC capture and concentration process constitutes a rapid solute decontamination pathway and solids containment option in perpetuity.

The power of the unexpected: Prediction errors enhance stereotype-based learning.

Stereotyping is a ubiquitous feature of social cognition, yet surprisingly little is known about how group-related beliefs influence the acquisition of person knowledge. Accordingly, in combination with computational modeling (i.e., Reinforcement Learning Drift Diffusion Model analysis), here we used a probabilistic selection task to explore the extent to which gender stereotypes impact instrumental learning. Several theoretically interesting effects were observed. First, reflecting the impact of cultural socialization on person construal, an expectancy-based preference for stereotype-consistent (vs. stereotype-inconsistent) responses was observed. Second, underscoring the potency of unexpected information, learning rates were faster for counter-stereotypic compared to stereotypic individuals, both for negative and positive prediction errors. Collectively, these findings are consistent with predictive accounts of social perception and have implications for the conditions under which stereotyping can potentially be reduced.

Electrophysiological correlates of self-prioritization.

Personally relevant stimuli exert a powerful influence on social cognition. What is not yet fully understood, however, is how early in the processing stream self-relevance influences decisional operations. Here we used a shape-label matching task in conjunction with electroencephalography and computational modeling to explore this issue. A theoretically important pattern of results was observed. First, a standard self-prioritization effect emerged indicating that responses to self-related items were faster and more accurate than responses to other-related stimuli. Second, a hierarchical drift diffusion model analysis revealed that this effect was underpinned by the enhanced uptake of evidence from self-related stimuli. Third, self-other discrimination during matching trials was observed at both early posterior N1 and late centro-parietal P3 components. Fourth, whereas the N1 was associated with the rate of information accumulation during decisional processing, P3 activity was linked with the evidential requirements of response selection. These findings elucidate the electrophysiological correlates of self-prioritization.

Self-relevance and the activation of attentional networks.

Recent theoretical accounts maintain that core components of attentional functioning are preferentially tuned to self-relevant information. Evidence in support of this viewpoint is equivocal, however, with research overly reliant on personally significant (i.e., familiar) stimulus inputs (e.g., faces, forenames) and a diverse range of methodologies. Addressing these limitations, here we utilised arbitrary items (i.e., geometric shapes) and administered the Attention Network Test (ANT) to establish the extent to which self-relevance (vs friend-relevance) moderates the three subsystems of attentional functioning-alerting, orienting, and executive control. The results revealed that only executive control was sensitive to the meaning of the stimuli, such that conflict resolution was enhanced following the presentation of self-associated compared with friend-associated shapes (i.e., cues). Probing the origin of this effect, a further computational analysis (i.e., Shrinking Spotlight Diffusion Model analysis) indicated that self-relevance facilitated the narrowing of visual attention. These findings highlight when and how the personal significance of otherwise trivial material modulates attentional processing.

Knock yourself out: Brief mindfulness-based meditation eliminates self-prioritization.

Recent research has asserted that self-prioritization is an inescapable facet of mental life, but is this viewpoint correct? Acknowledging the flexibility of social-cognitive functioning, here we considered the extent to which mindfulness-based meditation-an intervention known to reduce egocentric responding-attenuates self-bias. Across two experiments (Expt. 1, N = 160; Expt. 2, N = 160), using an object-classification task, participants reported the ownership of previously assigned items (i.e., owned-by-self vs. owned-by-friend) following a 5-minute period of mindfulness-based meditation compared with control meditation (Expt. 1) or no meditation (Expt. 2). The results revealed that mindfulness meditation abolished the emergence of the self-ownership effect during decision-making. An additional computational (i.e., drift diffusion model) analysis indicated that mindfulness meditation eliminated a prestimulus bias toward self-relevant (vs. friend-relevant) responses, increased response caution, and facilitated the rate at which evidence was accumulated from friend-related (vs. self-related) objects. Collectively, these findings elucidate the stimulus and response-related operations through which brief mindfulness-based meditation tempers self-prioritization.

Self-Prioritization Reconsidered: Scrutinizing Three Claims.

Such is the power of self-relevance, it has been argued that even arbitrary stimuli (e.g., shapes, lines, colors) with no prior personal connection are privileged during information processing following their association with the self (i.e., self-prioritization). This prioritization effect, moreover, is deemed to be stimulus driven (i.e., automatic), grounded in perception, and supported by specialized processing operations. Here, however, we scrutinize these claims and challenge this viewpoint. Although self-relevance unquestionably influences information processing, we contend that, at least at present, there is limited evidence to suggest that the prioritization of arbitrary self-related stimuli is compulsory, penetrates perception, and is underpinned by activity in a dedicated neural network. Rather, self-prioritization appears to be a task-dependent product of ordinary cognitive processes.

People perception and stereotype-based responding: task context matters.

Whether group impact social perception is a topic of renewed theoretical and empirical interest. In particular, it remains unclear when and how the composition of a group influences a core component of social cognition-stereotype-based responding. Accordingly, exploring this issue, here we investigated the extent to which different task requirements moderate the stereotype-related products of people perception. Following the presentation of same-sex groups that varied in facial typicality (i.e., high or low femininity/masculinity), participants had to report either the gender-related status of target words (i.e., a group-irrelevant gender-classification task) or whether the items were stereotypic or counter-stereotypic with respect to the preceding groups (i.e., a group-relevant stereotype-status task). Critically, facial typicality only impacted performance in the stereotype-status task. A further computational analysis (i.e., Diffusion Model) traced this effect to the combined operation of stimulus processing and response biases during decision-making. Specifically, evidence accumulation was faster when targets followed groups that were high (vs. low) in typicality and these arrays also triggered a stronger bias toward stereotypic (vs. counter-stereotypic) responses. Collectively, these findings elucidate when and how group variability influences people perception.

Sticky me: Self-relevance slows reinforcement learning.

A prominent facet of social-cognitive functioning is that self-relevant information is prioritized in perception, attention, and memory. What is not yet understood, however, is whether similar effects arise during learning. In particular, compared to other people (e.g., best friend) is information about the self acquired more rapidly? To explore this matter, here we used a probabilistic selection task in combination with computational modeling (i.e., Reinforcement Learning Drift Diffusion Model analysis) to establish how self-relevance influences learning under conditions of uncertainty (i.e., choices are based on the perceived likelihood of positive and negative outcomes). Across two experiments, a consistent pattern of effects was observed. First, learning rates for both positive and negative prediction errors were slower for self-relevant compared to friend-relevant associations. Second, self-relevant (vs. friend-relevant) learning was characterized by the exploitation (vs. exploration) of choice selections. That is, in a complex (i.e., probabilistic) decision-making environment, previously rewarded self-related outcomes were selected more often than novel - but potentially riskier - alternatives. The implications of these findings for accounts of self-function are considered.

What is the evidence for efficacy, effectiveness and safety of surgical interventions for plantar fasciopathy? A systematic review.

AIMS: To systematically review randomised control trials (RCT's) assessing the effectiveness and safety of surgical interventions in adults with plantar fasciopathy (PF). MATERIALS AND METHODS: We searched MEDLINE, EMBASE, Web of Science, Google Scholar, the Cochrane Central Register of Controlled Trials, trial registries and references lists. RCT's comparing surgical interventions with non-surgical or surgical comparisons in adults with PF were included. Primary outcomes were changes in first step pain severity/intensity, and incidence/nature of adverse events. Secondary outcomes included foot and ankle related disability/function, health related quality of life, cost effectiveness, changes in other reported measures of pain and medication use. Data were extracted at short-term (≤3 months post-intervention), medium-term (>3months-≤6 months post-intervention) or long-term (>6 months-≤2 years post-treatment). Certainty of evidence was evaluated using the modified Grading of Recommendations Assessment, Development and Evaluation (GRADE). RESULTS: From 3620 screened records, we included 8 studies comprising 345 patients. Substantial variation across trials precluded meta-analysis, hence a narrative synthesis was conducted. We judged all studies to have high risk of bias. For all outcome comparisons our GRADE judgement for the certainty of the evidence was very low. Three studies compared one type of surgery with another largely showing little to no difference in outcomes for pain, function or quality of life. Five studies compared surgery with non-surgical interventions-three providing very low certainty evidence that surgery may improve pain and function at long-term follow-up compared to non-surgical comparisons, whereas two studies provided no long-term between-group differences. Reporting of adverse events were inadequate, inconsistent or absent across all studies. CONCLUSION: There is a paucity of high certainty evidence to support or refute the effectiveness and safety of surgical interventions in the management of PF. We make recommendations for improving the evidence base in this field.

More or less of me and you: self-relevance augments the effects of item probability on stimulus prioritization.

Self-relevance exerts a powerful influence on information processing. Compared to material associated with other people, personally meaningful stimuli are prioritized during decision-making. Further exploring the character of this effect, here we considered the extent to which stimulus enhancement is impacted by the frequency of self-relevant versus friend-relevant material. In a matching task, participants reported whether shape-label stimulus pairs corresponded to previously learned associations (e.g., triangle = self, square = friend). Crucially however, before the task commenced, stimulus-based expectancies were provided indicating the probability with which both self- and friend-related shapes would be encountered. The results revealed that task performance was impacted by the frequency of stimulus presentation in combination with the personal relevance of the items. When self- and friend-related shapes appeared with equal frequencies, a self-prioritization effect emerged (Expt. 1). Additionally, in both confirmatory (Expt. 2) and dis-confirmatory (Expt. 3) task contexts, stimuli that were encountered frequently (vs. infrequently) were prioritized, an effect that was most pronounced for self-relevant (vs. friend-relevant) items. Further computational analyses indicated that, in each of the reported experiments, differences in performance were underpinned by variation in the rate of information uptake, with evidence extracted more rapidly from self-relevant compared to friend-relevant stimuli. These findings advance our understanding of the emergence and origin of stimulus-prioritization effects during decisional processing.

That's me in the spotlight: Self-relevance modulates attentional breadth.

A core prediction of models of social-cognitive functioning is that attention is preferentially tuned to self-relevant material. Surprisingly, however, evidence in support of this viewpoint is scant. Remedying this situation, here we demonstrated that self-relevance influences the distribution of attentional resources during decisional processing. In a flanker task (N = 60), participants reported if to-be-judged stimuli either denoted, or were owned by, the self or a friend. A consistent pattern of results emerged across both judgment tasks. Whereas the identification of friend-related targets was speeded when the items were flanked by compatible compared with incompatible flankers, responses to self-related targets were resistant to flanker interference. Probing the origin of these effects, a further computational analysis (i.e., Shrinking Spotlight Diffusion Model analysis) confirmed that self-relevance impacted the focusing of attention during decision-making. These findings highlight how self-relevance modulates attentional processing.

Judging me and you: Task design modulates self-prioritization.

An extensive literature has revealed the benefits of self-relevance during stimulus processing. Compared to material associated with other persons (e.g., friend, mother), self-relevant information elicits faster and more accurate responses (i.e., the self-prioritization effect). Probing the boundary conditions of this effect, recent research has sought to identify whether the advantages of self-relevance can be attenuated (or even eliminated) under certain circumstances. Continuing in this tradition, here we explored the extent to which basic aspects of the task design modulate self-prioritization. The results of two experiments demonstrated just such an effect. During both simultaneous (i.e., Expt. 1) and sequential (i.e., Expt. 2) versions of a standard shape-label matching task, self-prioritization was reduced when stimulus presentation was blocked (i.e., self- or friend-relevant items) compared to intermixed (i.e., self- and friend-relevant items). These findings highlight both the persistence of self-prioritization and its sensitivity to task-related variation.

Comparing person and people perception: Multiple group members do not increase stereotype priming.

A characteristic feature of daily life is encountering people in groups. Surprisingly, however, at least during the initial stages of processing, research has focused almost exclusively on the construal of single individuals. As such, it remains unclear whether person and people (i.e., group) perception yield comparable or divergent outcomes. Addressing this issue, here we explored a core social-cognitive topic-stereotype activation-by presenting both single and multiple facial primes in a sequential-priming task. In addition, the processes underlying task performance were probed using a drift diffusion model analysis. Based on prior work, it was hypothesised that multiple (vs. single) primes would increase stereotype-based responding. Across two experiments, a consistent pattern of results emerged. First, stereotype priming was insensitive to the number of primes that were presented and occurred only at a short prime-target stimulus onset asynchrony (i.e., 250 ms). Second, priming was underpinned by a bias towards congruent (vs. incongruent) prime-target responses. Collectively these findings advance understanding of the emergence and origin of stereotype priming during person and people perception.

On stopping yourself: Self-relevance facilitates response inhibition.

It is well documented that stimuli associated with the self are easier to process than identical material paired with other people (i.e., self-prioritization effect). Surprisingly, however, relatively little is known about how self-relevance impacts core aspects of executive functioning, notably response inhibition. Accordingly, here we used a stop-signal task to establish how effectively responses toward self-relevant (vs. other-relevant) stimuli can intentionally be inhibited. In the context of personal possession, participants were required to classify stimuli (i.e., pens and pencils) based on ownership (i.e., owned-by-self vs. owned-by-friend/stranger), unless an occasional auditory tone indicated that the response should be withheld. The results revealed the benefits of self-relevance on response inhibition. Compared with items owned by a friend or stranger, responses to self-owned objects were inhibited more efficiently. These findings confirm that self-relevance facilitates executive control.

Self-prioritization during stimulus processing is not obligatory.

An emerging literature has suggested that self-relevance automatically enhances stimulus processing (i.e., the self-prioritization effect). Specifically, during shape-label matching tasks, geometric shapes associated with the self are identified more rapidly than comparable stimuli paired with other targets (e.g., friend, stranger). Replicating and extending work that challenges the putative automaticity of this effect, here we hypothesized that self-relevance facilitates stimulus processing only when task sets draw attention to previously formed shape-label associations in memory. The results of a shape-classification task confirmed this prediction. Compared to shapes associated with a friend, those paired with the self were classified more rapidly when participants were required to report who the stimulus denoted (i.e., self or friend). In contrast, self-relevance failed to facilitate performance when participants judged either what the shape was (i.e., triangle or square, diamond or circle) or where it was located on the screen (i.e., above or below fixation). These findings further elucidate the conditions under which self-relevance does-and does not-influence stimulus processing.