ABSTRACT
OBJECTIVES: To evaluate the effects of green tea intake and zoledronic acid intravenous therapy on teeth socket repair. DESIGN: Sixty male albinus Wistar rats were divided into 4 groups: C-Control, intravenous (IV) 0.9% saline solution (SS), GT-1% green tea in drinking water and IV SS, BP-IV zoledronic acid (BP), and BP+GT-IV BP and 1% green tea. 0.035mg/kg of BP was administered every two weeks. After ten weeks, right upper molars were extracted and the green tea started to be offered for GT and BP+GT. After 7, 14, and 28days the animals were euthanized. RESULTS: Histopathology analysis revealed lack of socket repair in BP and BP+GT groups, which presented significant increased number of polimorphonuclear leukocytes at day 28, in comparison with C (p<0.05). No significant differences were detected between C and the experimental groups at the same period (p<0.05) when considering mononuclear leukocytes. Immunolabeling revealed that the association of BP and GT caused a slight disturbance in OPG/RANKL system and retarded Runx-2 labeling. Although strong TRAP labeling was observed, most of the positive cells in BP and BP+GT groups were not located on bone surface. CONCLUSIONS: Socket healing of rats treated with BP and regular drinking green tea presented no relevant differences in comparison to those treated with BP alone.
Subject(s)
Diphosphonates/pharmacology , Imidazoles/pharmacology , Plant Extracts/pharmacology , Tea/chemistry , Tooth Socket/drug effects , Wound Healing/drug effects , Animals , Core Binding Factor Alpha 1 Subunit/analysis , Drug Combinations , Immunohistochemistry , Leukocytes , Male , Maxilla , Osteonecrosis/drug therapy , Osteoprotegerin/analysis , Rats , Rats, Wistar , Tartrate-Resistant Acid Phosphatase/analysis , Tooth Socket/pathology , Zoledronic AcidABSTRACT
Objetivo: Avaliar a prevalência e tipos de maloclusão em escolares do município de Campinas, São Paulo. Método: Foram examinados 660 escolares, em três escolas do município de Campinas. A faixa etária variou de 6,5 até 18,1 anos (média ± d.p. = 12,2 ± 2,3 anos). Os exames clínicos intrabucais foram realizados por quatro dentistas devidamente treinados e calibrados, consistiram em inspeção visual, utilizando apenas espátulas de madeira descartáveis e sondas milimetradas, em salas cedidas pelas escolas, com boas condições de visão e iluminação natural. Os critérios adotados para classificar as oclusões normais e maloclusões foram os estipulados por Andrews(1), Angle(2) e Maia(3). Resultados: Os dados obtidos indicaram que não houve diferença estatisticamente significante entre os gêneros. A maloclusão foi encontrada em 87,4% dos escolares examinados, concordando com a maioria dos trabalhos nacionais e internacionais. A maloclusão de Classe I foi a mais prevalente (39,7%) entre os escolares examinados, seguida da Classe II, com 36% dos casos, sendo que a Classe II divisão 1 teve uma maior prevalência (22,7%) em relação à Classe II divisão 2 (13,3%). A maloclusão de Classe III esteve presente em 11,7% da amostra. Conclusão: A prevalência de maloclusão é alta e independente do gênero na população de escolares estudada. A maloclusão mais prevalente foi a de Classe I, seguida da classe II divisão 1.
Objective: To evaluate the prevalence and types of malocclusion in schoolchildren in the municipality of Campinas, São Paulo, Brazil. Method: Six hundred and sixty schoolchildren at three schools in the municipality of Campinas were examined. The age bracket ranged from 6.5 up to18.1 years (mean ± s.d. = 12.2 ± 2.3 years) The intraoral clinical exams were performed by four duly trained and calibrated dentists, consisted of visual inspection using only disposable wooden spatulas and millimetric probes, performed in rooms provided by the schools, with good conditions of visibility and natural lighting. The criteria adopted for classifying normal and malocclusion were those stipulated by Andrews(1), Angle(2) and Maia(3). Results: The data obtained indicated that there was no statistically significant difference between the genders. Malocclusion was found in 87.4% of the schoolchildren examined, in agreement with the majority of Brazilian and International studies. Class I malocclusion was the most prevalent (39.7%) among the schoolchildren examined, followed by Class II, with 36% of the cases, and there was higher prevalence of Class II division 1 (22.7%) in comparison with Class II division 2 (13.3%). Class III malocclusion was present in 11.7% of the sample. Conclusion: There is high prevalence of malocclusion, irrespective of gender, in the studied population of schoolchildren. The most prevalent malocclusion was Class I, followed by Class I division 1.
