1.
Bioorg Med Chem
; 25(6): 1963-1975, 2017 03 15.
Article
in English
| MEDLINE
| ID: mdl-28238512
ABSTRACT
Multipronged approach was used to synthesize a library of diverse C-8 cyclopentyl hypoxanthine analogs from a common intermediate III. Several potent and selective compounds were identified and evaluated for pharmacokinetic (PK) properties in Wistar rats. One of the compounds 14 with acceptable PK parameters was selected for testing in in vivo primary acute diuresis model. The compound demonstrated significant diuretic activity in this model.