ABSTRACT
Isolated caecal perforation following pancreatitis is a rare event. We report a case of severe non-necrotising pancreatitis complicated by caecal perforation that was managed successfully.
Subject(s)
Cecal Diseases/etiology , Intestinal Perforation/etiology , Pancreatitis/complications , Acute Disease , Aged , Female , Humans , Pneumoperitoneum/etiology , Tomography, X-Ray ComputedABSTRACT
Small bowel perforation following a capsule endoscopy (CE) is a rare but dreadful complication. We report a CE induced small bowel perforation in a patient with Crohn's disease where preoperative investigations failed to reveal any strictures.
Subject(s)
Capsule Endoscopy/adverse effects , Foreign-Body Migration/etiology , Intestinal Perforation/etiology , Intestine, Small/injuries , Peritoneum , Female , Foreign-Body Migration/diagnostic imaging , Humans , Intestinal Perforation/diagnostic imaging , Middle Aged , Peritonitis/diagnostic imaging , Peritonitis/etiology , RadiographyABSTRACT
1. Vincristine (1 mg/kg) and vinblastine (2 mg/kg) were injected intraperitoneally into the rats, 24 hr before the experiments. 2. Animals were anesthetized with 50 mg/kg of sodium pentobarbital and saliva was collected from vincristine-treated, vinblastine-treated and control animals using 8 mg/kg of pilocarpine as secretagogue. 3. Parotid saliva was analyzed for protein, amylase and Ca2+ content, and submandibular saliva for flow rate, protein and Ca2+ concentration. 4. Saliva from two treated groups was significantly lower (P < 0.01) in flow rate, amylase and protein content than that of control group. Calcium level was significantly increased (P < 0.05) in treated animals. 5. It is concluded that the antisecretory effects of vinca alkaloids may be consistent with their actions on salivary cell microtubules.
Subject(s)
Parotid Gland/drug effects , Parotid Gland/physiology , Submandibular Gland/drug effects , Submandibular Gland/physiology , Vinblastine/pharmacology , Vincristine/pharmacology , Amylases/metabolism , Animals , Calcium/physiology , Male , Organ Size/drug effects , Parotid Gland/anatomy & histology , Proteins/metabolism , Rats , Rats, Sprague-Dawley , Saliva/drug effects , Saliva/metabolism , Secretory Rate/drug effects , Submandibular Gland/anatomy & histologyABSTRACT
The Greig cephalopolysyndactyly syndrome is an uncommon dysmorphic syndrome characterized by preaxial and postaxial polysyndactyly and minor craniofacial anomalies. It has an autosomal dominant inheritance. A review of the literature has failed to show documentation of any dental or oral abnormalities. Therefore, we report on a patient with Greig syndrome who had a maxillary fibro-osseous lesion and multiple dental and oral abnormalities.
Subject(s)
Abnormalities, Multiple , Facial Bones/abnormalities , Fibroma/pathology , Maxillary Neoplasms/pathology , Osteoma/pathology , Skull/abnormalities , Syndactyly , Tooth Abnormalities/pathology , Adult , Female , Humans , SyndromeABSTRACT
Not only the endotoxic LPS preparations, but a non-toxic, lipid-free, non-mitogenic hydrolytic breakdown product of it (called PS) is also capable of inducing colony stimulating factor (CSF) release (1). Due to difficulties to reproduce above findings it became necessary to study the optimal conditions to obtain CSF active PS preparations. It was found that the CSF generating component of the highly heterogeneous PS mixture is sensitive to acidic hydrolyses, but it is less sensitive than the toxic site in the lipid moiety of the LPS. Carefully controlled optimal hydrolytic conditions give PS preparations which have less than one percent residual endotoxicity but maintained 40 to 80% of the original CSF generating capacity. Prolonged hydrolysis will destroy this activity too. Optimal dose of LPS and PS for CSF induction in mice differed widely. For LPS the optimal dose is 25 micrograms, injecting more gave a much reduced or non-detectable CSF level. Optimal dose for PS was 160 micrograms, and this generated a significantly higher CSF level than 25 micrograms LPS. At concentrations below 25 micrograms, LPS was clearly more active than PS. The CSF level reached its peak at 3-4 hours after other LPS or PS injection. Intravenous route was sometimes but not always more effective than intraperitoneal.
