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Article in English | MEDLINE | ID: mdl-24079272

ABSTRACT

As part of a project to generate a library of nucleosides as potential antiviral agents, a small subset of novel acyclic phosphonic acid nucleosides was prepared. Practical synthetic routes are described for three targets, which were then tested against HIV, hepatitis C virus (HCV), and Dengue virus.


Subject(s)
Acids, Acyclic/chemical synthesis , Antiviral Agents/chemical synthesis , Nucleosides/chemical synthesis , Phosphorous Acids/chemical synthesis , Acids, Acyclic/chemistry , Antiviral Agents/chemistry , Dengue/drug therapy , Dengue Virus/drug effects , HIV/drug effects , HIV Infections/drug therapy , Hepacivirus/drug effects , Humans , Molecular Structure , Nucleosides/chemistry , Phosphorous Acids/chemistry , Phosphorylation
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