ABSTRACT
Neuropsychiatric symptoms have long been acknowledged as a common comorbidity for individuals with allergic diseases. Proposed mechanisms for this relationship vary by disease and patient population and may include neuroinflammation and/or the consequent social implications of disease symptoms and management. We review connections between mental health and allergic rhinitis, atopic dermatitis, asthma, vocal cord dysfunction, urticaria, and food allergy. Many uncertainties remain and warrant further research, particularly with regards to how medications interact with pathophysiologic mechanisms of allergic disease in the neuroimmune axis. Proactive screening for mental health challenges, using tools such as the Patient Health Questionnaire (PHQ) and Generalized Anxiety Disorder (GAD) screening instruments among others, can aid providers in identifying patients who may need further psychiatric evaluation and support. Though convenient, symptom screening tools are limited by variable sensitivity and specificity and therefore require providers to remain vigilant for other mental health 'red flags'. Ultimately, understanding the connection between allergic disease and mental health empowers clinicians to both anticipate and serve the diverse physical and mental health needs of their patient populations.
