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Triton WR-1339 induced changes in the fatty acid composition of serum lipids in rats.

Orbán, E; Maderspach, A; Tomori, E.

Biochem Pharmacol ; 29(20): 2879-82, 1980 Oct 15.

Article in English | MEDLINE | ID: mdl-7437087

Subject(s)

Fatty Acids/blood , Lipids/blood , Polyethylene Glycols/pharmacology , Animals , Chemical Phenomena , Chemistry , Cholesterol/metabolism , Cholesterol Esters/metabolism , Phospholipids/blood , Rats , Time Factors , Triglycerides/blood

Capillary gas chromatographic studies of cholesterol biosynthesis in rats treated with EGYT-1299.

Tomori, E; Orbán, E; Maderspach, A.

J Chromatogr ; 191: 261-7, 1980 Apr 18.

Article in English | MEDLINE | ID: mdl-7380961

ABSTRACT

Cholesterol and desmosterol concentrations were assayed by high-performance capillary gas chromatography. It was established that no toxic desmosterol accumulation occurred either in the serum or liver of rats receiving EGYT-1299 treatment. Desmosterol accumulation induced by triparanol was reduced by the agent at doses ten times lower than Atromid S; consequently its cholesterol lowering effect may be attributed to interference with cholesterol biosynthesis.

Subject(s)

Cholesterol/metabolism , Chromatography, Gas/methods , Clofibrate/analogs & derivatives , Triparanol/pharmacology , Urea/analogs & derivatives , Animals , Clofibrate/pharmacology , Desmosterol/metabolism , Liver/drug effects , Liver/metabolism , Rats , Urea/pharmacology

[Hypobetalipoproteinemic effect of trans-2,10-dichloro-6-ethoxycarbonyl-12-methyldibenzo[d,g] [1,3]dioxocin (EGYT-1932, Crismel)]. / A transz 2,10-diklór-6-etoxikarbonil-12-metildibenzo [d,g] [1,3]) dioxocin (EGYT--1932, Crismel) hipobétalipoproteinémias hatásának vizsgálata.

Maderspach, A; Orbán, E.

Acta Pharm Hung ; 49(4): 182-6, 1979 Jul.

Article in Hungarian | MEDLINE | ID: mdl-224643

Subject(s)

Heterocyclic Compounds/pharmacology , Hypolipidemic Agents , Lipoproteins, LDL/blood , Animals , Hypercholesterolemia/blood , Rats

[Lipid decreasing effect of trans-2,10-dichloro-6-ethoxycarbonyl-12-methyldibenzo[d,g] [1,3]dioxocin (EGYT-1932, Crismel)]. / Transz-2,10-diklór-6-etoxikarbonil-12-metil-dibenzo [d,g] [1,3]-dioxocin (EGYT-1932, Crismel) lipidcsökkentö hatásának vizsgálata.

Maderspach, A; Orbán, E; Borsy, J; Fischer, J.

Acta Pharm Hung ; 49(4): 174-81, 1979 Jul.

Article in Hungarian | MEDLINE | ID: mdl-474140

Subject(s)

Heterocyclic Compounds/pharmacology , Hypolipidemic Agents , Animals , Clofibrate/pharmacology , Hyperlipidemias/blood , Rats

[The effect of clofibrate (ethyl-p-chlorophenoxy isobutyrate), M-451 (bis-p-chlorophenoxy-acetylurea) and phenobarbital on experimental liver damage in rats]. / A clofibrát (etil-p-klórfenoxi-izobutirát M--451: bisz-p-klórfenoxi-acetilurea) és fenobarbiturál hatása kísérletes májkárosodásban, patkányokon

Elek, S; Borsy, J; Maderspach, A; Polgári, I; Osváth, Z; Jámbor, E.

Acta Pharm Hung ; 44(1): 30-6, 1974 Mar.

Article in Hungarian | MEDLINE | ID: mdl-4849902

Subject(s)

Carbon Tetrachloride Poisoning/drug therapy , Clofibrate/therapeutic use , Hepatitis, Animal/prevention & control , Phenobarbital/therapeutic use , Animals , Cyanates/poisoning , Ethionine/poisoning , Liver/drug effects , Rats

[Syntheses of glyoxylic acid phenylacetates and their action on lipid metabolism]. / Glioxilsav-fenilacetálok szintézisei és zsíranyagcsere hatásai.

Fischer, J; Rákóczi, J; Mikite, G; Fodor, T; Maderspach, A; Borsy, J.

Acta Pharm Hung ; 43(5): 229-34, 1973 Sep.

Article in Hungarian | MEDLINE | ID: mdl-4755757

Subject(s)

Glycolates/chemical synthesis , Lipid Metabolism , Lipid Mobilization/drug effects , Animals , Anticholesteremic Agents , Glycolates/metabolism , Glycolates/pharmacology , Glycolates/toxicity , Lethal Dose 50 , Mice , Phenylacetates/pharmacology

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