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1.
Vascular ; : 17085381221124991, 2022 Sep 07.
Article in English | MEDLINE | ID: mdl-36071691

ABSTRACT

BACKGROUND: Despite being rare, pancreaticoduodenal artery aneurysms (PDAAs) carry a risk of rupture of up to 50% and are frequently associated with coeliac artery occlusion. METHODS: PubMed and Embase databases were searched using appropriate terms. The systematic review was conducted according to PRISMA guidelines. RESULTS: We present the case of a 2 cm pancreaticoduodenal artery aneurysm pre-operative angiography demonstrated that the coeliac artery was occluded and the pancreaticoduodenal artery was providing collateral blood supply to the liver. Treatment was a staged hybrid intervention inclusive of an aorto-hepatic bypass using a 6 mm graft, followed by coil embolisation of the aneurysm. We also present a systematic review of the management of PDAAs. Two hundred and ninety-two publications were identified initially with 81 publications included in the final review. Of the 258 peripancreatic aneurysms included, 175 (61%) were associated with coeliac artery disease either occlusion or stenosis. Abdominal pain was the main presentation in 158 cases. Rupture occurred in 111 (40%) of patients with only ten (3.8%) cases being unstable on presentation. Fifty (18%) cases were detected incidentally while investigating another pathology. Over half the cases (n=141/54.6%) were treated by trans arterial embolisation (TAE) alone, while 37 cases had open surgery only. Twenty-one cases needed TAE and a coeliac stent. Seventeen cases underwent hybrid treatment (open and endovascular). Sixteen cases were treated conservatively and in 26 cases, treatment was not specified. CONCLUSION: PDAAs are commonly associated with coeliac artery disease. The most common presentation is pain followed by rupture. The scarcity of literature about true peripancreatic artery aneurysms associated with CA occlusive disease makes it difficult to assess the natural history or the appropriate treatment. Revascularisation of hepatic artery is better done with bypass in setting of median arcuate ligament compression and occluded celiac trunk.

2.
Phlebology ; 37(8): 588-595, 2022 Sep.
Article in English | MEDLINE | ID: mdl-35762195

ABSTRACT

BACKGROUND: This study aimed to ascertain patients' experience of the out-patient venous service being provided,; identify the level of patient satisfaction with the service and identify areas for further improvement and development. METHOD: A prospective descriptive quantitative study. A questionnaire was distributed to all patients who used the service between June 2017 and March 2018. A total of 195 questionnaires was distributed with 162 valid questionnaires returned; response rate of 83%. RESULTS: This study found high satisfaction levels with endovenous ablation procedures, with concomitant phlebectomy, in the ambulatory outpatient setting and patient experiences of the service are overwhelmingly positive. CONCLUSION: Study findings support the management of ambulatory outpatient varicose vein endovenous ablation procedures as a feasible alternative to day surgery theatre settings and is the blueprint for future management of varicose vein surgery in Ireland.


Subject(s)
Laser Therapy , Varicose Veins , Ambulatory Surgical Procedures/methods , Humans , Laser Therapy/methods , Outpatients , Patient Satisfaction , Saphenous Vein/surgery , Treatment Outcome , Varicose Veins/surgery
3.
Ann Vasc Surg ; 82: 265-275, 2022 May.
Article in English | MEDLINE | ID: mdl-34902472

ABSTRACT

INTRODUCTION: The incidence of failed endovascular (EVAR) and open repair (OR) is increasing. Redo aortic repair is required in 10% of patients. Extension of the proximal sealing zone above the visceral arteries to adequate, healthier thoracic aorta using a fenestrated graft (FEVAR) can rescue a failing repair. A custom-made device can treat proximal type 1a endoleaks or proximal dilatation post endovascular or open repair, respectively. The aim of this investigation was to present a single-centre experience with FEVAR for patients with a failing aortic repair. METHODS: A prospectively maintained database of FEVAR patients treated with a ZenithⓇ Fenestrated endovascular (ZFEN) device (Cook Medical LLC, Bloomington, Indiana, USA) was interrogated for individuals who had the device implanted as a rescue therapy after prior endovascular (EVAR) or open repair (OR). Statistical analysis was performed with SPSS v 25 software. RESULTS: Between January 1, 2011 and March 31, 2019, 17 ZFEN devices were implanted. 10 patients had a type 1a endoleak from a prior EVAR and 7 patients had proximal disease progression after prior OR. There were 12 males and 5 females, median age of 75 (interquartile range, IQR 7). 76.4% (n = 13) of patients had an American Society of Anaesthesiologists (ASA) grade of 3. Primary technical success was 70.5% (n = 12). Of the remainder, 4 cases (24%) had a type III endoleak at completion angiogram; of which, 2 patients (12%) required re-intervention within 30 days. One further case (6%) had primary assisted technical success as stenting of a flow limiting dissection flap in an iliac vessel was required. Peri-operative rate of deployment related complications and systemic complications were 5.8% (n = 1) and 35% (n = 6), respectively. Median length of hospital stay was 11 days (IQR 11). There was no mortality within the study follow up. Overall 30-day re-intervention rate was 23.5%. Overall survival was 92% at one year. CONCLUSION: FEVAR is a safe but technically challenging option for rescue of failing aortic repairs. These are a high-risk group of patients and this is reflected in the high post-operative morbidity rate. Technical success was high and 30-day mortality was low.


Subject(s)
Aortic Aneurysm, Abdominal , Blood Vessel Prosthesis Implantation , Endovascular Procedures , Aortic Aneurysm, Abdominal/complications , Aortic Aneurysm, Abdominal/diagnostic imaging , Aortic Aneurysm, Abdominal/surgery , Blood Vessel Prosthesis/adverse effects , Endoleak/diagnostic imaging , Endoleak/etiology , Endoleak/surgery , Female , Humans , Male , Prosthesis Design , Reoperation/adverse effects , Retrospective Studies , Treatment Outcome
4.
Thromb Haemost ; 121(1): 86-97, 2021 Jan.
Article in English | MEDLINE | ID: mdl-32932544

ABSTRACT

BACKGROUND: The relationship between von Willebrand factor antigen (VWF:Ag), VWF propeptide (VWFpp), VWFpp/VWF:Ag ratio, ADAMTS13 activity, and microembolic signal (MES) status in carotid stenosis is unknown. METHODS: This prospective, multicenter study simultaneously assessed plasma VWF:Ag levels, VWFpp levels and ADAMTS13 activity, and their relationship with MES in asymptomatic versus symptomatic moderate-to-severe (≥50-99%) carotid stenosis patients. One-hour transcranial Doppler ultrasound of the middle cerebral arteries classified patients as MES+ve or MES-ve. RESULTS: Data from 34 asymptomatic patients were compared with 43 symptomatic patients in the "early phase" (≤4 weeks) and 37 patients in the "late phase" (≥3 months) after transient ischemic attack (TIA)/ischemic stroke. VWF:Ag levels were higher (p = 0.049) and VWFpp/VWF:Ag ratios lower (p = 0.006) in early symptomatic than in asymptomatic patients overall, and in early symptomatic versus asymptomatic MES-ve subgroups (p ≤0.02). There were no intergroup differences in VWFpp expression or ADAMTS13 activity (p ≥0.05). VWF:Ag levels and ADAMTS13 activity decreased (p ≤ 0.048) and VWFpp/VWF:Ag ratios increased (p = 0.03) in symptomatic patients followed up from the early to late phases after TIA/stroke. Although there were no differences in the proportions of symptomatic and asymptomatic patients with blood group O, a combined analysis of early symptomatic and asymptomatic patients revealed lower median VWF:Ag levels in patients with blood group O versus those without blood group O (9.59 vs. 12.32 µg/mL, p = 0.035). DISCUSSION: VWF:Ag expression, a marker of endothelial ± platelet activation, is enhanced in recently symptomatic versus asymptomatic carotid stenosis patients, including in MES-ve patients, and decreases with ADAMTS13 activity over time following atherosclerotic TIA/ischemic stroke.


Subject(s)
ADAMTS13 Protein/metabolism , Carotid Stenosis/metabolism , Intracranial Embolism/metabolism , von Willebrand Factor/metabolism , ADAMTS13 Protein/blood , Aged , Carotid Stenosis/blood , Carotid Stenosis/complications , Female , Humans , Intracranial Embolism/blood , Intracranial Embolism/etiology , Male , Middle Aged , Prospective Studies , von Willebrand Factor/analysis
5.
J Cereb Blood Flow Metab ; 40(11): 2201-2214, 2020 11.
Article in English | MEDLINE | ID: mdl-31711341

ABSTRACT

The relationship between plaque morphology, cerebral micro-embolic signals (MES) and platelet biomarkers in carotid stenosis patients warrants investigation.We combined data from two prospective, observational studies to assess carotid plaque morphology and relationship with cerebral MES and platelet biomarkers in patients with recently symptomatic (≤4 weeks of transient ischaemic attack (TIA)/ischaemic stroke) versus asymptomatic carotid stenosis. Plaque morphology on ultrasound was graded with Grey-Scale Median (GSM) and Gray-Weale (GW) scoring. Bilateral transcranial Doppler ultrasound classified patients as 'MES+ve' or 'MES-ve'. Full blood counts were analysed and flow cytometry quantified CD62P and CD63 expression, leucocyte-platelet complexes and reticulated platelets.Data from 42 recently symptomatic carotid stenosis patients were compared with those from 36 asymptomatic patients. There were no differences in median GSM scores between symptomatic and asymptomatic patients (25 vs. 30; P = 0.31) or between MES+ve vs. MES-ve symptomatic patients (36 vs. 25; P = 0.09). Symptomatic patients with GSM-echodense plaques (GSM ≥25) had higher platelet counts (228 vs. 191 × 109/L), neutrophil-platelet (3.3 vs. 2.7%), monocyte-platelet (6.3 vs. 4.55%) and lymphocyte-platelet complexes (2.91 vs. 2.53%) than 'asymptomatic patients with GSM-echodense plaques' (P ≤ 0.03).Recently, symptomatic carotid stenosis patients with 'GSM-echodense plaques' have enhanced platelet production/secretion/activation compared with their asymptomatic counterparts. Simultaneous assessment with neurovascular imaging and platelet biomarkers may aid risk-stratification in carotid stenosis.


Subject(s)
Biomarkers/blood , Blood Platelets/metabolism , Carotid Stenosis/blood , Carotid Stenosis/diagnosis , Intracranial Embolism/diagnosis , Intracranial Embolism/etiology , Plaque, Atherosclerotic/pathology , Aged , Asymptomatic Diseases , Carotid Stenosis/complications , Comorbidity , Disease Management , Female , Humans , Intracranial Embolism/drug therapy , Intracranial Embolism/prevention & control , Ischemic Attack, Transient , Male , Middle Aged , Phenotype , Plaque, Atherosclerotic/diagnostic imaging , Platelet Aggregation Inhibitors/therapeutic use , Severity of Illness Index , Symptom Assessment , Ultrasonography, Doppler, Transcranial
6.
Thromb Haemost ; 119(5): 821-833, 2019 May.
Article in English | MEDLINE | ID: mdl-30769362

ABSTRACT

INTRODUCTION: Cerebral micro-embolic signals (MES) predict risk of stroke in carotid stenosis patients. However, MES-negative 'recently symptomatic patients' also have a higher stroke risk than 'asymptomatic patients'. Differences in platelet activation status may contribute to this disparity in risk. METHODS: This prospective, observational study assessed platelet biomarkers and their relationship with MES in asymptomatic versus symptomatic moderate (≥50-69%) or severe (≥70-99%) carotid stenosis patients. Full blood count parameters were measured and whole-blood flow cytometry was used to quantify platelet surface CD62P and CD63 expression and leucocyte-platelet complex formation. Bilateral simultaneous transcranial Doppler ultrasound of the middle cerebral arteries classified patients as 'MES positive' or 'MES negative'. RESULTS: Data from 34 asymptomatic patients were compared with those from 43 symptomatic patients in the 'early phase' (≤ 4 weeks) and 37 of these symptomatic patients in the 'late phase' (≥ 3 months) after transient ischaemic attack/ischaemic stroke. There were no differences in %CD62P or %CD63 expression between early or late symptomatic and asymptomatic patients overall (p > 0.05). The percentage of lymphocyte-platelet complexes was higher in early symptomatic than in asymptomatic patients (2.8 vs. 2.16%; p < 0.001). MES were more commonly observed in early symptomatic (31.4%; p = 0.027) but not in late symptomatic (6.7%; p = 0.996) versus asymptomatic patients (7.1%). The percentage of lymphocyte-platelet complexes was higher in early symptomatic than in asymptomatic MES-negative patients (2.7 vs. 2.17%; p = 0.02). CONCLUSION: These data add to the evidence that leucocyte-platelet complex formation/platelet activation is increased in recently symptomatic versus asymptomatic patients, and may contribute to the pathogenesis of first and subsequent strokes in carotid stenosis patients, including those who are MES negative.


Subject(s)
Blood Platelets/physiology , Carotid Stenosis/diagnosis , Intracranial Embolism/diagnosis , Leukocytes/physiology , Aged , Asymptomatic Diseases , Cell Communication , Disease Progression , Female , Humans , Male , Middle Aged , Platelet Activation , Prognosis , Prospective Studies
7.
Gates Open Res ; 2: 52, 2018.
Article in English | MEDLINE | ID: mdl-32803126

ABSTRACT

Background: Transformative sanitation technologies aim to treat fecal sludge (FS) by thermal processes and recover resources from it. There is a paucity of data describing the relevant properties of FS as viable feedstock for thermal treatment in major geographical target areas, such as India. Methods: This study characterized FS collected from septic tanks in two cities located in the Indian southern state of Tamil Nadu. FS samples were obtained at the point of discharge from trucks in Tiruppur (n=85 samples) and Coimbatore (n=50 samples). Additionally, biosolids obtained from sewage treatment plants (STP) in the cities of Coimbatore and Madurai were characterized. Total solids (TS) were measured, and proximate and ultimate analysis were conducted according to methods used by the fuel industry. Additionally, the ash content was analyzed for heavy metal using standard methods. Results: The average higher heating value (HHV) across all FS samples in Tiruppur (13.4 MJ/kg) was significantly higher than in Coimbatore (5.4 MJ/kg), which was partially attributed to the high ash content of 69% in the latter samples.  The HHV of the biosolids samples ranged from 10 to 12.2 MJ/Kg. The average total solids (TS) content for FS was 3.3% and 2.0% for Tiruppur and Coimbatore respectively, while the median TS content for the two cities was 2.3% and 1.2%. The heavy metal content of the ash was found to be below the thresholds for land disposal. Conclusions: This is one of the first studies that has systematically characterized the calorific and mineral content of septage and biosolids in several cities in India. We expect these data to serve as input data in the design of thermal processes for fecal sludge treatment.

8.
J Neurol Sci ; 376: 133-139, 2017 05 15.
Article in English | MEDLINE | ID: mdl-28431600

ABSTRACT

INTRODUCTION: The relationship between on-treatment platelet reactivity and cerebral micro-embolic signals (MES) is unknown, and has not been previously simultaneously assessed in asymptomatic and symptomatic carotid stenosis patients. METHODS: Consecutive eligible patients with ≥50% asymptomatic or recently symptomatic carotid stenosis (≤4weeks following TIA/ischaemic stroke) were recruited to this pilot study. Symptomatic patients were followed up to the 'late' phase (≥3months) following symptom onset or carotid intervention; longitudinal data were analysed from symptomatic patients with data available at both time-points. Platelet function/reactivity was assessed with the PFA-100® to measure collagen-ADP (C-ADP) and collagen-epinephrine (C-EPI) closure times in citrate-anticoagulated whole blood. Bilateral simultaneous 1-hour transcranial Doppler ultrasound (TCD) monitoring of the middle cerebral arteries was performed to classify patients as MES +ve or MES -ve. RESULTS: 31 patients with ≥50% asymptomatic and 46 with early symptomatic carotid stenosis or occlusion were included. 35 symptomatic patients were followed up to the late phase (23 following carotid intervention). Prevalence of 'high on-treatment platelet reactivity' (HTPR) on the C-EPI cartridge did not differ between asymptomatic and symptomatic patients overall, but was lower in 'symptomatic post-intervention' than asymptomatic patients on aspirin monotherapy (10% vs. 50%; p=0.03). The prevalence of HTPR on the C-EPI cartridge decreased between the early and late phases in symptomatic patients (63% vs. 34%; p=0.017), including those on aspirin monotherapy (p=0.016). There were no significant differences in HTPR status between asymptomatic vs. early or late symptomatic MES +ve or MES -ve patients. DISCUSSION: Carotid interventional treatment, presumably in combination with resolution of the acute phase response, may decrease the prevalence of HTPR in patients with recently symptomatic carotid stenosis over time. Preliminary subgroup analysis suggests that successful intervention may reduce the prevalence of aspirin-HTPR in symptomatic patients to lower levels than asymptomatic medically-treated patients on aspirin monotherapy. Larger, longitudinal studies are warranted to reassess the impact of more intensive secondary preventive treatment on ex vivo platelet function at different levels of shear stress in carotid stenosis patients.


Subject(s)
Carotid Stenosis/blood , Carotid Stenosis/drug therapy , Intracranial Embolism/complications , Intracranial Embolism/diagnostic imaging , Platelet Aggregation Inhibitors/therapeutic use , Aged , Aspirin/adverse effects , Aspirin/therapeutic use , Brain/diagnostic imaging , Carotid Stenosis/diagnostic imaging , Carotid Stenosis/epidemiology , Case-Control Studies , Clopidogrel , Disease Progression , Female , Humans , Intracranial Embolism/drug therapy , Intracranial Embolism/epidemiology , Longitudinal Studies , Male , Middle Aged , Pilot Projects , Platelet Aggregation Inhibitors/adverse effects , Prevalence , Proof of Concept Study , Ticlopidine/adverse effects , Ticlopidine/analogs & derivatives , Ticlopidine/therapeutic use , Ultrasonography, Doppler, Transcranial
9.
Eur Heart J Case Rep ; 1(1): ytx002, 2017 Aug.
Article in English | MEDLINE | ID: mdl-31020061

ABSTRACT

Intra-aortic balloon pump (IABP) use following myocardial infarction is now infrequent and reserved for cases of cardiogenic shock. As their use declines, so does our ability to promptly recognize and manage potential problems that may arise. A serious but rare complication of IABP insertion is balloon entrapment within the arterial tree. In this report, we share our experience of a case of balloon entrapment within the right common iliac artery and successful removal of the device via groin cut down under general anaesthesia.

10.
J Vasc Surg ; 55(4): 956-62, 2012 Apr.
Article in English | MEDLINE | ID: mdl-22226182

ABSTRACT

INTRODUCTION: A significant proportion of patients undergoing endovascular aneurysm repair (EVAR) have common iliac artery aneurysms (CIAA). Aneurysmal involvement at the iliac bifurcation potentially undermines long-term durability. METHODS: Patients with CIAA who underwent EVAR were identified in two teaching hospitals. Bell-bottom technique (BBT; iliac limb ≥20 mm) or internal iliac artery embolization and limb extension to the external iliac artery (IIE + EE) were used. Outcome between these two approaches was compared. RESULTS: We identified 185 patients. Indication for EVAR included asymptomatic abdominal aortic aneurysm (AAA) in 157, symptomatic or ruptured aneurysm in 19, and CIAA in nine. Mean AAA diameter was 59 mm. Among 260 large CIAAs that were treated, BBT was used to treat 166 CIAA limbs, and 94 limbs underwent IIE + EE. Total reintervention rates were 11% for BBT (n = 19) and 19.1% for IIE + EE (n = 18; P = .149). Rates of reintervention for type Ib or III endoleak were 4% for BBT (n = 7) and 4% for IIE + EE (n = 4; P > .99). The difference in limb patency rates was not significant. The 30-day mortality rate was 1%. Median follow-up was 22 months. Complications did not differ significantly between the two groups; however, the combined incidence of perioperative complications and reinterventions was higher in the IIE + EE group (49% vs 22%; P = .002). CONCLUSIONS: The combined incidence of perioperative complications and reinterventions is significantly higher with IIE + EE than with BBT; therefore, when feasible, BBT is desirable.


Subject(s)
Aneurysm, Ruptured/surgery , Aortic Aneurysm/surgery , Blood Vessel Prosthesis Implantation/methods , Embolization, Therapeutic/methods , Iliac Aneurysm/therapy , Aged , Aged, 80 and over , Aneurysm, Ruptured/diagnostic imaging , Aneurysm, Ruptured/mortality , Angioplasty/methods , Aortic Aneurysm/complications , Aortic Aneurysm/diagnostic imaging , Aortography/methods , Blood Vessel Prosthesis , Blood Vessel Prosthesis Implantation/mortality , Cohort Studies , Female , Follow-Up Studies , Humans , Iliac Aneurysm/complications , Iliac Aneurysm/diagnostic imaging , Male , Middle Aged , Retrospective Studies , Risk Assessment , Severity of Illness Index , Survival Rate , Tomography, X-Ray Computed/methods , Treatment Outcome , Vascular Patency/physiology
11.
J Med Case Rep ; 5: 401, 2011 Aug 22.
Article in English | MEDLINE | ID: mdl-21859469

ABSTRACT

INTRODUCTION: Spontaneous iliac arteriovenous fistulae are a rare clinical entity. Such localized fistulation is usually a result of penetrating traumatic or iatrogenic injury. Clinical presentation can vary greatly but commonly includes back pain, high-output congestive cardiac failure and the presence of an abdominal bruit. Diagnosis, therefore, is often incidental or delayed. CASE PRESENTATION: We report a case of a spontaneous ilio-iliac arteriovenous fistula in a 68-year-old Caucasian man detected following presentation with unilateral claudication and congestive cardiac failure. Following computed tomography evaluation, the fistula was successfully treated with a combined endovascular (aorto-uni-iliac device) and open (femoro-femoral crossover) approach. CONCLUSION: Endovascular surgery has revolutionized the management of such fistulae and we report an interesting case of a high-output iliac arteriovenous fistulae successfully treated with a hybrid vascular approach.

12.
J Vasc Surg ; 49(1): 60-5, 2009 Jan.
Article in English | MEDLINE | ID: mdl-18829237

ABSTRACT

OBJECTIVES: Cumulative radiation dose, cost, and increased demand for computed tomography aortography (CTA) suggest that duplex ultrasonography (DU) may be an alternative to CTA-based surveillance. We compared CTA with DU during endovascular aneurysm repair (EVAR) follow-up. METHODS: Patients undergoing EVAR had clinical and radiological follow-up data entered in a prospectively maintained database. For the purpose of this study, the gold standard test for endoleak detection was CTA, and an endoleak detected on DU alone was assumed to be a false positive result. DU interpretation was performed independently of CTA and vice versa. RESULTS: One hundred thirty-two patients underwent EVAR, of whom 117 attended for follow-up ranging from six months to nine years (mean, 32 months). Adequate aneurysm sac visualisation on DU was not possible in 1.7% of patients, predominantly due to obesity. Twenty-eight endoleaks were detected in 28 patients during follow-up. Of these, 24 were initially identified on DU (four false negative DU examinations), and eight had at least one negative CTA with a positive DU prior to diagnosis. Twenty-three endoleaks were type II in nature and three of these patients had increased sac size. There was one type I and four type III endoleaks. Two of these (both type III) had an increased sac size. Of 12 patients with increased aneurysm size of 5 mm or more at follow-up, five had an endoleak visible on DU, yet negative CTA and a further five had endoleak visualisation on both DU and CTA. Of six endoleaks which underwent re-intervention, all were initially picked up on DU. One of these endoleaks was never demonstrated on CTA and a further two had at least one negative CTA prior to endoleak confirmation. Positive predictive value for DU was 45% and negative predictive value 94%. Specificity of DU for endoleak detection was 67% when compared with CTA, because of the large number of false positive DU results. Sensitivity for DU was 86%, with all clinically significant endoleaks demonstrated on CTA also detected on DU. CONCLUSION: Despite its low positive predictive value, we found DU to be a sensitive test for the detection of clinically significant endoleaks. Given concerns about cumulative radiation exposure and cost, and the surprisingly low sensitivity of CTA for endoleak detection in this series, selective CTA based on DU surveillance may be a more appropriate long-term strategy.


Subject(s)
Aortic Aneurysm/diagnostic imaging , Aortography/methods , Blood Vessel Prosthesis Implantation/instrumentation , Blood Vessel Prosthesis , Tomography, X-Ray Computed , Ultrasonography, Doppler, Color , Aged , Aged, 80 and over , Angiography, Digital Subtraction , Aortic Aneurysm/surgery , Blood Vessel Prosthesis Implantation/adverse effects , Databases as Topic , Female , Humans , Male , Middle Aged , Predictive Value of Tests , Prospective Studies , Prosthesis Failure , Radiation Dosage , Reoperation , Sensitivity and Specificity , Treatment Outcome
13.
J Vasc Surg ; 43(3): 504-512, 2006 Mar.
Article in English | MEDLINE | ID: mdl-16520164

ABSTRACT

OBJECTIVE: Infrainguinal angioplasty provides a minimally invasive alternative to bypass surgery in patients with critical ischemia. This study aimed to determine the 2-year patency, limb salvage, and survival rates in patients who underwent infrainguinal angioplasty in a unit where angioplasty is used preferentially whenever possible for critical ischemia. METHODS: A total of 333 consecutive patients who presented with rest pain, tissue loss, or both and who underwent an infrainguinal intervention in the 4-year period between January 1998 and January 2002 were divided into femoropopliteal and femorodistal groups. The TransAtlantic Inter-Society Consensus angiogram scoring system was used to classify the lesions. Angioplasty was the preferred procedure in all patients for whom a stump or portion of a superficial femoral artery was patent. Exclusion criteria included the concomitant or sequential treatment of iliac lesions. Patients were followed up after surgery with ankle-brachial indices and duplex ultrasonography. RESULTS: A total of 180 patients underwent 198 angioplasties. Primary cumulative patency, limb salvage, and survival for femoropopliteal angioplasty (n = 166) at 2 years were 75%, 90%, and 88%, respectively, and 60%, 76%, and 82% for infrapopliteal angioplasty (n = 32). At 30 days, mortality was 2.7%, and the complication rate was 8.3%. There was a restenosis rate (>50%) of 68% and 65% at 2 years for the femoropopliteal and infrapopliteal angioplasty groups, respectively. Seven patients required repeat angioplasty of the same site, 30 underwent subsequent bypass, and 16 of 43 occluded limbs were amputated. A total of 153 comparative control patients underwent 162 bypass procedures during the same period. Primary cumulative patency, limb salvage, and survival for femoropopliteal bypass (n = 80) at 2 years were 69%, 87%, and 76%, respectively, and were 53%, 57%, and 64% for infrapopliteal bypass (n = 82). The 30-day mortality for bypass was 5.2%, the complication rate was 35%, and 31 limbs were amputated. CONCLUSIONS: The results of this study on the intermediate-term outcome of angioplasty suggest that angioplasty, when used preferentially for critical ischemia, in anatomically suitable patients provides very acceptable limb salvage and survival despite a relatively high restenosis rate.


Subject(s)
Angioplasty/methods , Ischemia/surgery , Leg/blood supply , Minimally Invasive Surgical Procedures/methods , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Ischemia/diagnostic imaging , Ischemia/mortality , Male , Middle Aged , Postoperative Complications , Treatment Outcome , Ultrasonography , Vascular Patency
14.
AJR Am J Roentgenol ; 185(4): 1069-73, 2005 Oct.
Article in English | MEDLINE | ID: mdl-16177436

ABSTRACT

OBJECTIVE: Our objective was to determine if direction of flow within the vertebral artery could be reliably determined by evaluation of flow-sensitive, low-resolution 2D time-of-flight (TOF) localizer images taken before 3D contrast-enhanced MR angiography (3D CEMRA) sequences in patients with unsuspected subclavian steal syndrome. CONCLUSION: Vertebral artery patency on 3D CEMRA in cases in which the vessel is absent on the TOF localizer in association with ipsilateral subclavian artery stenosis indicates reversal of flow in the vertebral artery and confirms the subclavian steal phenomenon. The combination of anatomic imaging with 3D CEMRA with functional information provided by the low-resolution TOF localizer confirms the diagnosis of subclavian steal without additional imaging.


Subject(s)
Magnetic Resonance Angiography/methods , Subclavian Steal Syndrome/diagnosis , Adolescent , Aged , Aged, 80 and over , Contrast Media , Female , Humans , Male , Meglumine/analogs & derivatives , Middle Aged , Organometallic Compounds
15.
J Arthroplasty ; 19(3): 391-4, 2004 Apr.
Article in English | MEDLINE | ID: mdl-15067658

ABSTRACT

An infected total hip arthroplasty remains one of the most challenging problems faced by orthopaedic surgeons from diagnosis through treatment. We present the case of a 58-year-old woman who was referred to our service with an infected revision total hip arthroplasty. The hip had migrated medially, and the patient had recently noted the presence of blood discharging through a chronic sinus. Angiography revealed a mycotic aneurysm of the external iliac artery. An emergency procedure incorporating a femorofemoral bypass graft and a Girdlestone procedure was undertaken. This is the first reported case of a leaking mycotic aneurysm presenting acutely with blood discharging through a previously chronically discharging sinus tract.


Subject(s)
Aneurysm, Infected/etiology , Arthroplasty, Replacement, Hip/adverse effects , Iliac Aneurysm/etiology , Prosthesis-Related Infections , Staphylococcal Infections/etiology , Female , Humans , Middle Aged , Reoperation
16.
Vasc Endovascular Surg ; 36(5): 389-92, 2002.
Article in English | MEDLINE | ID: mdl-12244429

ABSTRACT

The most prevalent lesion of the vertebral artery is an atheromatous plaque located at its origin from the subclavian artery. A case of successful management of a symptomatic vertebral artery aneurysm due to Ehlers-Danlos syndrome is reported. The patient had asymptomatic posterior intracerebral artery dissection on the contralateral side. A common carotid artery to V-3 segment bypass using reversed saphenous vein graft was carried out. Avulsion of the V-2 segment occurred peroperatively and endovascular coil embolization of the vertebral artery aneurysm was performed. Endovascular equipment and training must be in the armamentarium of vascular surgeons as more complex cases are being treated, which demands new approaches for ultimate clinical success. This unique case outlines what might unexpectedly occur. Endovascular intervention as an adjuvant procedure provides a satisfactory outcome in what could have been a catastrophe.


Subject(s)
Aneurysm/therapy , Ehlers-Danlos Syndrome/complications , Embolization, Therapeutic , Vertebral Artery/injuries , Aneurysm/etiology , Female , Humans , Intraoperative Complications , Middle Aged
17.
J Endovasc Ther ; 9(2): 225-8, 2002 Apr.
Article in English | MEDLINE | ID: mdl-12010106

ABSTRACT

PURPOSE: To report the successful endovascular embolization of a pancreaticoduodenal aneurysm (PDA). CASE REPORT: A 56-year-old man with a history of pancreatitis presented with insidious, progressive epigastric pain for the preceding 6 months. Contrast-enhanced computed tomography (CT) and selective hepatic digital subtraction angiography identified a 7.7-cm aneurysm that arose from the pancreaticoduodenal branch of the gastroduodenal artery. Through a percutaneous common femoral approach, 10 stainless steel coils were delivered to occlude the aneurysm. A single coil detached and became lodged in a small branch of the right hepatic artery without sequelae. At 26 months, duplex and CT scans show continued occlusion of the aneurysm. CONCLUSIONS: Transcatheter coil embolization should be the first choice treatment for aneurysms of the pancreaticoduodenal artery.


Subject(s)
Aneurysm/therapy , Duodenum/blood supply , Embolization, Therapeutic , Pancreas/blood supply , Angiography, Digital Subtraction , Arteries , Humans , Male , Middle Aged , Tomography, X-Ray Computed
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