Subject(s)
Antioxidants/chemistry , Indole Alkaloids/chemistry , Monoterpenes/chemistry , Rubiaceae/chemistry , Antioxidants/isolation & purification , Antioxidants/pharmacology , Crystallography, X-Ray , Indole Alkaloids/isolation & purification , Indole Alkaloids/pharmacology , Models, Molecular , Molecular Structure , Monophenol Monooxygenase/antagonists & inhibitors , Monoterpenes/isolation & purification , Monoterpenes/pharmacology , Plant Bark/chemistry , Plant Extracts/chemistry , Plant Extracts/isolation & purification , Plant Extracts/pharmacologyABSTRACT
The title compound, C30H44O5, is a penta-cyclic triterpene isolated from the Cameroonian medicinal plant Nauclea Pobeguinii and known as quafrinoic acid. The mol-ecule is composed of five fused six-membered rings, four of which adopt a chair conformation and one a half-chair conformation. Intra-molecular C-Hâ¯O hydrogen-bond inter-actions exist, which generate S6 and S8 rings. In the crystal, mol-ecules are linked by pairs of O-Hâ¯O hydrogen bonds, linking R22(8) rings into chains running parallel to the a axis; these chains are further connected into layers parallel to the ab plane by C-Hâ¯O hydrogen bonds. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from Hâ¯H (79.4%) and Oâ¯H (20.4%) inter-actions.