ABSTRACT
Alexitimia and depression may or not coexist with others risk factors (comportment o physical). Frecuently they have relation with socio-echonomic status and with ethnia. Sometimes are determinants of the atherosclerotic process by increasing the vascular reactivity by the alteration of the evolution. There is no information in our country about this problem in general population. The present study result of the investigation of these aspects and the comportamental and physical factors of arterial disease, in a population of Cordoba province (Argentina Republic).
Subject(s)
Affective Symptoms/epidemiology , Depression/epidemiology , Vascular Diseases/epidemiology , Vascular Diseases/psychology , Adult , Age Distribution , Aged , Argentina/epidemiology , Arteries , Chi-Square Distribution , Female , Humans , Male , Middle Aged , Population Surveillance , Prevalence , Risk Factors , Sex Distribution , Sex Factors , Socioeconomic FactorsABSTRACT
Entidades psicopatológicas como alexitimia y depresión, pueden coexistir o no con factores de riesgo de enfermedad arterial o ser entidades independientes. Tienen frecuentemente relación con aspectos socio-económico-culturales y con la etnia; a veces son determinantes del proceso ateroesclerótico por alterar la reactividad vascular (Alexitimai) o agravadores del proceso evolutivo (depresión). Materiales y métodos: Existe escasa información sobre esta tematica en nuestro país: la existente se refiere a los mismos en muestras seleccionadas, no de poblaciones generales (urbanas o rurales). Resultados: se exponen los resultados obtenidos de lainvestigación de esos factores en una población de la Provincia de Córdoba (RA), donde simultáneamente se estudiaron factores de orden fisico y conductual. Conclusiones: La prevalencia de la depresión es más elevada que en otras poblaciones
Alexitimia and depression may or not coexist with others risk factors (comportment o physical). Frecuently they have relation with socio-echonomic status and with ethnia. Sometimes are determinants of the atherosclerotic process by increasing the vascular reactivity by the alteration of the evolution. There is no information in our country about this problem in general population. The present study result of the investigation of these aspects and the comportamental and physical factors of arterial disease, in a population of Cordoba province (Argentina Republic).
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Affective Symptoms/epidemiology , Depression/epidemiology , Population Surveillance , Vascular Diseases/epidemiology , Vascular Diseases/psychology , Age Distribution , Argentina/epidemiology , Chi-Square Distribution , Prevalence , Risk Factors , Sex Distribution , Sex Factors , Socioeconomic FactorsABSTRACT
From the AF, the smaller risk is controversial. The influence of the general and environmental components on IR is not know in a satisfactory way. OBJECTIVES: The influence of AF on the prevail IR in two rural communities of Córdoba with different fenotipical configuration and IR risk. MATERIAL AND METHODS: Transverse study (survey, clinical and biochemical checkup) over 1143 people of Oncativo community (ON) and Dean Funes (DF), inclusion: n = 673 (30-60 years old) Normal ECG, no diabetics. Sorts AF according to the spend of calories (Kcal/sem): a) sedentary (< 500), b) low (5001-1000), c) regular (1001-2500), and d) High (> 2500). IR is HOMA > 2.5; where [HOMA = (Glucemia * Insulina)/ 4.5]. RESULTS: AF: 31.4% sedentary, 20.2% low, 26.3% regular and 22.1% high. 16.5% IR in ON opposite 34.8% en DF (P < 0.001), IR in ON 8.2% with AF high opposite 18.8% the rest (P = 0.032), 36.8% and 34.2% like in DF (P = 0.67). With the adjusted results for age and community it was found less IMC (P = 0.002) and waist circumference (P = 0.042) than the most category of AF. The blood pressure had not a meaningful change, lipid profile or HOMA depending of AF. CONCLUSION: if a benefit of AF over IR exists, it will be conditioned for genetics and environmental primaries determiners.
Introducción: El menor riesgo de IR a partir de la AF es controvertido. No se conoce satisfactoriamente el peso de los componentes genérico y ambiental sobre la IR. Objetivos: Influencia de AF sobre prevalencia de IR en dos comunidades del interior de la provincia de Córdoba de configuración fenotípica y riesgo a IR diferentes. Material y Métodos: Estudio transversal (encuesta, examen clínico y bioquímico) sobre 1143 personas de la comunidad de Oncativo (ON) y Deán Funes (DF), Inclusión: n= 673 (30-60 años), ECG normal, no diabéticos. Clases AF según gasto calórico (Kcallsem): a) Sedentario (500), b) Baja (501-1000), c) Regular (10012500) Y d) Alta (> 2500). IR es HOMA > 2,5; donde [HOMA =(Glucemia. Insulina) /4.5]. Resultados: AF: 31,4% sedentario, 20,2% bajo, 26,3% regular y 22,1 % alto. 16,5%IRenONvs34,8%enDF(P< 0,00l), IR en ON 8,2% con AF alta vs 18,8% el resto (P=0,032), 36,8% y 34,2% ídem en DF (P= 0,67). Ajustados los resultados por edad y comunidad, se notó menos IMC (P= 0,002) Y circunferencia de cintura (P= 0,042) a mayor categoría de AF. No hubo cambio significativo de tensión arterial, perfil lipídico o HOMA en función de AF Conclusión: De existir un beneficio de AF sobre IR, podría estar condicionado por determinantes primarios de orden genético y/o ambiental.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Adaptation, Physiological/physiology , Exercise/physiology , Blood Glucose/metabolism , Insulin Resistance , Rural Population , Argentina/epidemiology , Body Mass Index , Body Composition/physiology , Epidemiologic Methods , Obesity/epidemiology , Obesity/metabolismABSTRACT
From the AF, the smaller risk is controversial. The influence of the general and environmental components on IR is not know in a satisfactory way. OBJECTIVES: The influence of AF on the prevail IR in two rural communities of Córdoba with different fenotipical configuration and IR risk. MATERIAL AND METHODS: Transverse study (survey, clinical and biochemical checkup) over 1143 people of Oncativo community (ON) and Dean Funes (DF), inclusion: n = 673 (30-60 years old) Normal ECG, no diabetics. Sorts AF according to the spend of calories (Kcal/sem): a) sedentary (< 500), b) low (5001-1000), c) regular (1001-2500), and d) High (> 2500). IR is HOMA > 2.5; where [HOMA = (Glucemia * Insulina)/ 4.5]. RESULTS: AF: 31.4% sedentary, 20.2% low, 26.3% regular and 22.1% high. 16.5% IR in ON opposite 34.8% en DF (P < 0.001), IR in ON 8.2% with AF high opposite 18.8% the rest (P = 0.032), 36.8% and 34.2% like in DF (P = 0.67). With the adjusted results for age and community it was found less IMC (P = 0.002) and waist circumference (P = 0.042) than the most category of AF. The blood pressure had not a meaningful change, lipid profile or HOMA depending of AF. CONCLUSION: if a benefit of AF over IR exists, it will be conditioned for genetics and environmental primaries determiners.(AU)
Introducción: El menor riesgo de IR a partir de la AF es controvertido. No se conoce satisfactoriamente el peso de los componentes genérico y ambiental sobre la IR. Objetivos: Influencia de AF sobre prevalencia de IR en dos comunidades del interior de la provincia de Córdoba de configuración fenotípica y riesgo a IR diferentes. Material y Métodos: Estudio transversal (encuesta, examen clínico y bioquímico) sobre 1143 personas de la comunidad de Oncativo (ON) y Deán Funes (DF), Inclusión: n= 673 (30-60 años), ECG normal, no diabéticos. Clases AF según gasto calórico (Kcallsem): a) Sedentario (500), b) Baja (501-1000), c) Regular (10012500) Y d) Alta (> 2500). IR es HOMA > 2,5; donde [HOMA =(Glucemia. Insulina) /4.5]. Resultados: AF: 31,4% sedentario, 20,2% bajo, 26,3% regular y 22,1 % alto. 16,5%IRenONvs34,8%enDF(P< 0,00l), IR en ON 8,2% con AF alta vs 18,8% el resto (P=0,032), 36,8% y 34,2% ídem en DF (P= 0,67). Ajustados los resultados por edad y comunidad, se notó menos IMC (P= 0,002) Y circunferencia de cintura (P= 0,042) a mayor categoría de AF. No hubo cambio significativo de tensión arterial, perfil lipídico o HOMA en función de AF Conclusión: De existir un beneficio de AF sobre IR, podría estar condicionado por determinantes primarios de orden genético y/o ambiental.(AU)
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Adaptation, Physiological/physiology , Blood Glucose/metabolism , Exercise/physiology , Insulin Resistance , Rural Population , Argentina/epidemiology , Body Composition/physiology , Body Mass Index , Epidemiologic Methods , Obesity/epidemiology , Obesity/metabolismABSTRACT
BACKGROUND: Polymerase chain reaction (PCR) allows detection of Trypanosoma cruzi in blood throughout the course of Chagas' disease. OBJECTIVE: To determine whether T cruzi DNA detected by PCR is associated with progression to chronic Chagas cardiomyopathy. DESIGN: Prospective cohort study. SETTING: A tertiary care centre in Argentina. PATIENTS: 56 consecutive patients with chronic T cruzi infection. METHODS: Clinical examination, ECG, and Doppler echocardiography were carried out at baseline and at the end of the follow up. Detection of T cruzi DNA by PCR amplifying a nuclear sequence was undertaken in all patients at baseline. MAIN OUTCOME MEASURES: Progression was defined as death from chronic cardiomyopathy or the presence of a new ECG or left ventricular echocardiographic abnormality at the end of follow up. RESULTS: The 56 patients (21 male, 35 female; mean (SD) age, 56.0 (11.3) years) were followed for a mean 936.3 (244.39) days. Progression to cardiomyopathy was detected in 12 patients (21.4%). Three of these patients died after baseline evaluation. Univariate analysis showed that a positive PCR (relative risk 4.09, 95% confidence interval (CI) 1.60 to 9.85) and male sex (5.00, 95% CI 1.65 to 15.73) were associated with progression. Multivariable logistic regression indicated that both sex and PCR were independent variables affecting the outcome. CONCLUSIONS: In a cohort of seropositive individuals, patients with T cruzi DNA detected by PCR and male patients were at higher risk of progression. These results highlight the importance of T cruzi in the pathophysiology of chronic cardiomyopathy.
Subject(s)
Chagas Cardiomyopathy/parasitology , Parasitemia/parasitology , Trypanosoma cruzi/isolation & purification , Adult , Aged , Aged, 80 and over , Animals , Chagas Cardiomyopathy/diagnosis , Chagas Cardiomyopathy/physiopathology , Cohort Studies , DNA, Protozoan/analysis , Disease Progression , Electrocardiography , Female , Follow-Up Studies , Heart Block/parasitology , Humans , Male , Middle Aged , Parasitemia/diagnosis , Parasitemia/physiopathology , Polymerase Chain Reaction/methods , Prognosis , Prospective Studies , Risk Factors , Sex Factors , Stroke VolumeABSTRACT
In the present work, we obtained an immobilized phospholipase A(2) system through covalent coupling by using an acrylic polymer Eupergit C as support. The immobilized enzyme from cobra venom (Naja naja naja) showed good retention activity and excellent stability. Both properties are of great importance for biomedical applications such as hypercholesterolemia treatments.
Subject(s)
Enzymes, Immobilized/metabolism , Phospholipases A/metabolism , Enzyme Stability , Enzymes, Immobilized/chemistry , KineticsSubject(s)
Chagas Cardiomyopathy/blood , Endothelin-1/blood , Adult , Chagas Disease/blood , Chronic Disease , Female , Humans , Male , Middle Aged , RadioimmunoassayABSTRACT
In this work we studied the effect of Ca(2+) on the ability of immobilized PLA(2) to hydrolyze phospholipid substrates either in aggregate or monomeric forms. We use a kinetic methodology for the determination of dissociation constants of soluble and immobilized PLA(2)-Ca(2+) complexes. This approach allows us to obtain the values of the dissociation constants of enzyme-Ca(2+) (K(x)) and enzyme-Ca(2+)-substrate (K'(x)) complexes from the kinetic data obtained at different substrate and Ca(2+) concentrations. Results using mixed micelles of phospholipid-Triton X-100 showed that, in most cases, productive complexes were destabilized by immobilization of PLA(2). However, a correct analysis of the interaction must be independent of the classical modes of PLA(2) action toward lipid surfaces. Thus, a substrate in monomeric form was also employed to analyze the effect of immobilization on hydrolysis rate in the absence of interfacial activation. Kinetic data showed that the immobilization affected severely the mode of PLA(2) action. The kinetic data also suggested that immobilization promoted conformational alterations in the Ca(2+)-binding site, destabilizing the productive complex enzyme-Ca(2+)-phospholipid.
Subject(s)
Calcium/metabolism , Phospholipases A/metabolism , Animals , Bees , Enzyme Activation , Enzymes, Immobilized , Kinetics , Phospholipids/metabolism , Structure-Activity Relationship , Surface PropertiesABSTRACT
Participes de la idea de que la Patología y evolución de la Enfermedad de Chagas son hechos complejos y admiten hipotesis de factores múltiples, después de tener evidencias por los trabajos analizados del denominado Período Intermedio se podría inferir: 1.- Sólo con Serología (+), ECG y Teleradiografía normales parece incompleto hoy rotular a pacientes en este Período. Se deberá incluir al menos un estudio Holter, un Ecocardiograma y una prueba de Denervación del SNA. 2.- El pronóstico de un paciente determinado en este Período no puede efectuarse sólo en el marco de una fórmula única y de alcance general: el infectado es muy probable que desarrolle en el tiempo manifestaciones orgánicas. si evolucionan podemos asumir que esas manifestaciones son preclínicas. Si no lo hacen, son subclínicas. 3.- La posibilidad de una prueba debiera excluirlos del grupo de Período Intermedio y quizás formar un subgrupo aparte o integrar ya los lesionados crónicos. 4.- Todas estas incógnitas, no son suficientemente develadas, exigen nuevos trabajos prospectivos y cooperativos
Subject(s)
Humans , Male , Female , Biopsy/statistics & numerical data , Chagas Cardiomyopathy/therapy , Chagas Disease/therapy , Complement C1 Inactivator Proteins , ElectrophysiologySubject(s)
Ebstein Anomaly/diagnosis , Adult , Echocardiography , Electrocardiography , Humans , Male , Phonocardiography , Radiography, Thoracic , Retrospective StudiesSubject(s)
Coronary Disease/diagnostic imaging , Heart/diagnostic imaging , Radioisotopes , Thallium , Adult , Aged , Exercise Test , Female , Humans , Male , Middle Aged , Radionuclide Imaging , Regression AnalysisSubject(s)
Myocardial Contraction , Phonocardiography , Adult , Child , Child, Preschool , Female , Humans , Kinetocardiography , Male , Reference Values , Ventricular FunctionABSTRACT
Se realizó un apexcardiograma con su primera derivada, un pulso carotídeo y un ecocardiograma a 20 niños normales (10 de sexo femenino y 10 masculino), cuyo rango de edades osciló entre 4 y 11 años. El objetivo del presente trabajo fue hallar valores normales de diversos índices de esos registros en nuestro medio y correlacionarlos con los obtenidos en adultos. Se realizaron además ecuaciones de regresión para calcular la duración de las fases sistólicas en relación a la frecuencia cardíaca. Las mediciones efectuadas arrojaron los siguientes resultados: 1) R-dA/dt 48 + ou - 7 mseg. (en adultos: 50 + ou - 12 mseg.). 2) Porcentaje de positividad de la dA/dt 54 + ou - 4 ( en adultos: 56 + ou - 8). 3) Tiempo de ascenso sistólico del apexcardiograma (TASA): 83 + ou - 8 mseg. (en adultos: 99 + ou - 10 mseg.) 4) Tiempo de ascenso de la deflexión positiva de la primera derivada (TADP): 52 + ou - 6 mseg. (en adultos: 52 + ou - 10 mseg.). 5) Altura porcentual de onda "a": 7 + ou - 3% (en adultos: 8 + ou -3%). 6) Indice de amplitud diastólica (DATI): 0,81 + ou -0,09 (en adultos: 0,60 + ou - 0,19). 7) Sístole electromecánica (Q-A2): 367,2 + ou - 17 mseg. (corregido: 460 + ou - 15 mseg.). 8) Período eyectivo (PE): 280,7 + ou - 19 mseg. (corregido: 356 + ou - 15 mseg.). 9) Período preeyectivo (PPE): 87 + ou - 13 mseg. (corregido: 103 + ou - mseg.). 10) Indice sistólico (IS): 0,30 + ou - 0,04
