ABSTRACT
OBJECTIVE: Systemic sclerosis (SSc) is a fibrotic immune-mediated disease of unknown etiology. Among its clinical manifestations, pulmonary involvement is the leading cause of mortality in patients with SSc. However, the genetic factors involved in lung complication are not well defined. We aimed to review the association of the MIF gene, which encodes a cytokine implicated in idiopathic pulmonary hypertension among other diseases, with the susceptibility and clinical expression of SSc, in addition to testing the association of this polymorphism with SSc-related pulmonary involvement. METHODS: A total of 4392 patients with SSc and 16,591 unaffected controls from 6 cohorts of European origin were genotyped for the MIF promoter variant rs755622. An inverse variance method was used to metaanalyze the data. RESULTS: A statistically significant increase of the MIF rs755622*C allele frequency compared with controls was observed in the subgroups of patients with diffuse cutaneous SSc (dcSSc) and with pulmonary arterial hypertension (PAH) independently (dcSSc: p = 3.20E-2, OR 1.13; PAH: p = 2.19E-02, OR 1.32). However, our data revealed a stronger effect size with the subset of patients with SSc showing both clinical manifestations (dcSSc with PAH: p = 6.91E-3, OR 2.05). CONCLUSION: We reviewed the association of the MIF rs755622*C allele with SSc and described a phenotype-specific association of this variant with the susceptibility to develop PAH in patients with dcSSc.
Subject(s)
Genetic Predisposition to Disease , Hypertension, Pulmonary/genetics , Intramolecular Oxidoreductases/genetics , Macrophage Migration-Inhibitory Factors/genetics , Polymorphism, Single Nucleotide , Promoter Regions, Genetic , Scleroderma, Diffuse/genetics , Alleles , Gene Frequency , Genetic Association Studies , Genotype , Humans , Hypertension, Pulmonary/etiology , Scleroderma, Diffuse/complicationsSubject(s)
Endocarditis, Bacterial/microbiology , Escherichia coli Infections , Mitral Valve/microbiology , Aged , Bacteremia/complications , Bacteremia/microbiology , Diabetes Mellitus, Type 2/complications , Endocarditis, Bacterial/etiology , Escherichia coli Infections/diagnosis , Fatal Outcome , Female , Humans , Hypertension/complicationsABSTRACT
No disponible
Subject(s)
Female , Adult , Humans , Myositis, Inclusion Body/etiology , Scleroderma, Systemic/complications , Diagnosis, Differential , Myositis, Inclusion Body/diagnosisABSTRACT
No disponible
Subject(s)
Female , Aged , Humans , Bacteremia/complications , Bacteremia/microbiology , Endocarditis, Bacterial/microbiology , Escherichia coli Infections/diagnosis , Mitral Valve/microbiology , Endocarditis, Bacterial/etiology , Fatal Outcome , Hypertension/complications , Diabetes Mellitus, Type 2/complicationsSubject(s)
Fibrinolytic Agents/adverse effects , Hemothorax/chemically induced , Pleural Effusion/drug therapy , Tissue Plasminogen Activator/adverse effects , Adult , Drug Administration Routes , Female , Fibrinolytic Agents/administration & dosage , Humans , Pneumonia/complications , Pneumonia/drug therapy , Tissue Plasminogen Activator/administration & dosageABSTRACT
No disponible
