ABSTRACT
Methotrexate (MTX) has been used in the treatment of psoriasis and other dermatological diseases for more than 50 years. However, there is limited evidence regarding its effect, dose and monitoring, and a lack of consensus regarding how the drug should be used in daily practice. Although the use of MTX is governed by guidelines, such as the European S3-Guidelines and the National Institute for Health and Care Excellence (NICE) guideline, it is important to discuss and adjust these guidelines to national standards. An expert meeting was held in Denmark at the end of 2014, in order to reach consensus regarding the use of MTX in dermatological practice in Denmark. Participants included dermatologists, hepatologists, paediatricians, clinical biochemists and a rheumatologist. Topics discussed were: liver disease monitoring, teratogenic effects of MTX, risk of cancer, and use of MTX in children. We report here the conclusions of this expert meeting regarding use of MTX in dermatological practice.
Subject(s)
Dermatology/standards , Immunosuppressive Agents/administration & dosage , Methotrexate/administration & dosage , Psoriasis/drug therapy , Adult , Age Factors , Chemical and Drug Induced Liver Injury/diagnosis , Chemical and Drug Induced Liver Injury/etiology , Child , Consensus , Denmark , Drug Dosage Calculations , Female , Humans , Immunosuppressive Agents/adverse effects , Liver Function Tests , Male , Methotrexate/adverse effects , Neoplasms/chemically induced , Neoplasms/diagnosis , Patient Safety , Pregnancy , Pregnancy Complications/chemically induced , Pregnancy Complications/diagnosis , Psoriasis/diagnosis , Psoriasis/immunology , Risk Assessment , Risk Factors , Time Factors , Treatment OutcomeSubject(s)
Amorphophallus/chemistry , Cosmetics/chemistry , Dermatitis, Allergic Contact/etiology , Facial Dermatoses/etiology , Hand Dermatoses/etiology , Preservatives, Pharmaceutical/adverse effects , Thiazoles/adverse effects , Adult , Female , Gas Chromatography-Mass Spectrometry , Humans , Patch TestsABSTRACT
BACKGROUND: Allergic contact dermatitis resulting from the use of permanent hair dyes is common. Approximately 100 hair dye chemicals are permitted in Europe. Hair dye ingredients may change over time, and hence new hair dye allergens should be looked for continuously. OBJECTIVES: To review positive patch test reactions to the coupler 2-amino-4-hydroxyethylaminoanisole sulfate 2% pet. from 2005 to 2014. METHODS: Patch test results from the Allergen Bank database for eczema patients patch tested with 2-amino-4-hydroxyethylaminoanisole sulfate 2% pet. from 2005 to 2014 were reviewed. RESULTS: A total of 902 dermatitis patients (154 from the dermatology department and 748 from 65 practices) were patch tested with amino-4-hydroxyethylaminoanisole sulfate 2% pet. from 2005 to 2014. Thirteen (1.4%) patients had a positive patch test reaction. Our results do not indicate irritant reactions. CONCLUSIONS: 2-Amino-4-hydroxyethylaminoanisole sulfate is a new but rare contact allergen.
