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Carbohydr Polym ; 251: 117025, 2021 Jan 01.
Article in English | MEDLINE | ID: mdl-33142585

ABSTRACT

Cellulose has been extracted from a wide range of land resources, whereas it has been scarcely exploited from marine resources. Cellulose from green seaweeds can be extracted together with smaller molecules called ulvans. We have successfully extracted and characterized cellulose from Ulva sp. Solid state 13C NMR indicated the presence of ulvans in the cellulose extracts. The extracted cellulose was blended with polylactide and polydioxanone and electrospun into nanofibrous mats with a range of physico-chemical properties. These cellulose-based scaffolds were assessed in vitro using fibroblast cells and showed accelerated cell growth. In vivo biocompatibility studies using a Wistar rat model indicated the absence of foreign body response and enhanced angiogenesis.


Subject(s)
Biocompatible Materials , Cellulose , Nanofibers/therapeutic use , Polysaccharides , Tissue Engineering , Tissue Scaffolds , Animals , Biocompatible Materials/chemistry , Cell Line , Cell Proliferation , Cellulose/chemistry , Female , Fibroblasts , Male , Mice , Neovascularization, Physiologic , Polysaccharides/chemistry , Rats , Rats, Wistar , Skin/metabolism , Ulva/chemistry
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