The factors affecting the timing of bone union after closing-wedge high tibial osteotomy.

OBJECTIVE: Closing-wedge high tibial osteotomy (CWHTO) for medial osteoarthritis of the knee is one of the effective osteotomy methods, especially for patients with cartilage damage of the patellofemoral joint, flexion contracture, and requiring a large correction angle.While the bone union at the osteotomy site is finally obtained after CWHTO, there are often differences in the period of the bone union. The purpose of the present study is to investigate the factors affecting the timing of bone union after CWHTO. METHODS: 16 cases of CWHTO were included; they were performed by the same surgeon using precisely the same implants. Among 16 cases in the present study, nobody used low-intensity pulsed ultrasound (LIPUS) within three months after the operation. The patients were divided into two Groups using Plane X-ray and CT within three months after surgery: Group D (8 knees; bone healing was not seen at all) and Group E (8 knees; bone healing was seen). RESULTS: There were no significant differences in mean age between the two groups, but body mass index (BMI) and bone mineral density (BMD) were significantly higher in Group D (p < 0.05). CONCLUSION: The present study suggests that BMI and BMD may affect the timing of bone union after CWHTO. BACKGROUND: Closing-wedge high tibial osteotomy (CWHTO) for medial osteoarthritis of the knee is one of the effective osteotomy methods. The frequency of selecting CWHTO in our hospital in Japan is high, especially for patients with cartilage damage of the patellofemoral joint, flexion contracture, and requiring a large correction angle. On the other hand, while the bone union at the osteotomy site is obtained with both procedures, there are often differences in bone union time for CWHTO compared to Opening-wedge high tibial osteotomy (OWHTO). This difference might affect the early clinical outcome of the operations. We hypothesized that there is some factor to affect bone healing of CWHTO for individual patients. PURPOSE: To investigate the factors affecting the timing of bone union after CWHTO.

Regulation of the glucose supply from capillary to tissue examined by developing a capillary model.

A new glucose transport model relying upon diffusion and convection across the capillary membrane was developed, and supplemented with tissue space and lymph flow. The rate of glucose utilization (J util) in the tissue space was described as a saturation function of glucose concentration in the interstitial fluid (C glu,isf), and was varied by applying a scaling factor f to J max. With f = 0, the glucose diffusion ceased within ~20 min. While, with increasing f, the diffusion was accelerated through a decrease in C glu,isf, but the convective flux remained close to resting level. When the glucose supplying capacity of the capillary was measured with a criterion of J util /J max = 0.5, the capacity increased in proportion to the number of perfused capillaries. A consistent profile of declining C glu,isf along the capillary axis was observed at the criterion of 0.5 irrespective of the capillary number. Increasing blood flow scarcely improved the supplying capacity.

Mechanisms underlying the volume regulation of interstitial fluid by capillaries: a simulation study.

BACKGROUND: Control of the extracellular fluid volume is one of the most indispensable issues for homeostasis of the internal milieu. However, complex interdependence of the pressures involved in determination of fluid exchange makes it difficult to predict a steady-state tissue volume under various physiological conditions without mathematical approaches. METHODS: Here, we developed a capillary model based on the Starling's principle, which allowed us to clarify the mechanisms of the interstitial-fluid volume regulation. Three well known safety factors against edema: (1) low tissue compliance in negative pressure ranges; (2) lymphatic flow driven by the tissue pressure; and (3) protein washout by the lymph, were incorporated into the model in sequence. RESULTS: An increase in blood pressure at the venous end of the capillary induced an interstitial-fluid volume increase, which, in turn, reduced negative tissue pressure to prevent edema. The lymphatic flow alleviated the edema by both carrying fluid away from the tissue and decreasing the colloidal osmotic pressure. From the model incorporating all three factors, we found that the interstitial-fluid volume changed quickly after the blood pressure change, and that the protein movement towards a certain equilibrium point followed the volume change. CONCLUSION: Mathematical analyses revealed that the system of the capillary is stable near the equilibrium point at steady state and normal physiological capillary pressure. The time course of the tissue-volume change was determined by two kinetic mechanisms: rapid fluid exchange and slow protein fluxes.