1.
Carbohydr Res
; 481: 23-30, 2019 Jul 15.
Article
in English
| MEDLINE
| ID: mdl-31220628
ABSTRACT
We synthesized phenylacetylenes containing ß-lactoside, ß-cellobioside, or ß-maltoside, and polymerized them to produce the corresponding poly (phenylacetylene)s. In these poly (phenylacetylene)s, the pendent carbohydrates were tethered to the mainchains by serinol spacers. Because similar glycosyl serinol units are found in the natural glycosphingolipids in cell membranes, the densely packed carbohydrate clusters along the poly (phenylacetylene) mainchains act as molecular mimics of cell surface glycoclusters. We analyzed the conformation of the glycosylated poly (phenylacetylene)s using circular dichroism spectroscopy, and found that the spatial carbohydrate packing within the glycoclusters changed on the addition of salts.