ABSTRACT
1. The role of testosterone (T) in growth was evaluated in 11 prepubertal hypopituitary males during two 15-day periods separated by a 4-week interval, i.e., before (PRE-T period) and during T ester treatment (50 mg every 5 days, 3 im doses-T period). 2. T increased growth hormone (GH) secretion, assessed by 4-h rhythm (mean +/- SEM = 1.90 +/- 0.27 vs 1.77 +/- 0.21 ng/ml; P < 0.05) and after a GHRH stimulus (3.42 +/- 0.54 vs 3.08 +/- 0.43 ng/ml; P < 0.05) as compared to the PRE-T period. 3. T also increased basal somatomedin-C (SM-C) levels (0.20 +/- 0.03 vs 0.15 +/- 0.02 U/ml; P < 0.001) and SM-C generation. After GH was administered in 4 im doses (0.01, 0.02, 0.05 and 0.1 U/kg), SM-C levels were 0.31 +/- 0.08 vs 0.24 +/- 0.07 U/ml, P < 0.001. T did not change incremental (absolute minus basal) SM-C levels (0.15 +/- 0.08 vs 0.12 +/- 0.07 U/ml; P > 0.05). 4. The results suggest that T increased plasma SM-C levels by stimulating residual GH secretion in hypopituitary males.
Subject(s)
Growth Hormone/drug effects , Growth Hormone/deficiency , Growth Hormone/metabolism , Insulin-Like Growth Factor I/drug effects , Puberty/drug effects , Testosterone/therapeutic use , Adolescent , Adult , Analysis of Variance , Child , Growth Hormone/blood , Humans , Hypopituitarism/blood , Hypopituitarism/drug therapy , Hypopituitarism/epidemiology , Insulin-Like Growth Factor I/analysis , Male , Puberty/blood , Time FactorsABSTRACT
1. The role of testosterone (T) in growth was evaluated in 11 prepubertal hypopituitary males during two 15-day periods separated by a 4-week interval, i.e., before (PRE-T period) and during T ester treatment (50 mg every 5 days, 3 im doses-T period). 2. T increased growth hormone (GH) secretion, assessed by 4-h rhythm (mean +/- SEM = 1.90 +/- 0.27 vs 1.77 +/- 0.21 ng/ml; P < 0.05) and after a GHRH stimulus (3.42 +/- 0.54 vs 3.08 +/- 0.43 ng/ml; P < 0.05) as compared to the PRE-T period. 3. T also increased basal somatomedin-C (SM-C) levels (0.20 +/- 0.03 vs 0.15 +/- 0.02 U/ml; P < 0.001) and SM-C generation. After GH was administered in 4 im doses (0.01, 0.02, 0.05 and 0.1 U/kg), SM-C levels were 0.31 +/- 0.08 vs 0.24 +/- 0.07 U/ml, P < 0.001. T did not change incremental (absolute minus basal) SM-C levels (0.15 +/- 0.08 vs 0.12 +/- 0.07 U/ml; P > 0.05). 4. The results suggest that T increased plasma SM-C levels by stimulating residual GH secretion in hypopituitary males
Subject(s)
Humans , Male , Insulin-Like Growth Factor I/drug effects , Puberty/drug effects , Growth Hormone/deficiency , Growth Hormone/drug effects , Growth Hormone , Testosterone/therapeutic use , Adolescent , Adult , Analysis of Variance , Child , Hypopituitarism/blood , Hypopituitarism/drug therapy , Hypopituitarism/epidemiology , Insulin-Like Growth Factor I/analysis , Puberty/blood , Growth Hormone/blood , Time FactorsABSTRACT
Sao analisados tres pacientes que apresentaram comprometimento da funcao respiratoria apos acidente por Crotalus durissus. As manifestacoes respiratorias surgiram nas primeiras 48 horas apos a picada do ofidio e consistiram de dispneia, taquipneia, uso da musculatura acessoria da respiracao (casos 1 e 2) e batimento das aletas nasais (caso 2). Dois pacientes (casos 1 e 2) apresentaram insuficiencia respiratoria aguda. O diagnostico desta complicacao no caso 1 foi clinico pois o paciente apresentou apneia. O paciente do caso 2, 24 horas apos o acidente ofidico apresentou dificuldade respiratoria intensa e periodos de apneia sendo intubado, permanecendo em respiracao espontanea. Houve agravamento dos sinais clinicos de insuficiencia respiratoria e a determinacao de pH e gases do sangue arterial mostrou em relacao ao exame inicial elevacao da pressao parcial de gas carbonico (40 mmHg para 50,3 mmHg) caracterizando insuficiencia ventilatoria aguda. Ambos foram tratados com emprego de ventilacao artificial mecanica, tendo o paciente do caso 1 permanecido no ventilador durante 33 dias e o do caso 2 durante 15 dias. Ambos desenvolveram insuficiencia renal aguda, necessitaram de dialise peritoneal e recuperaram a funcao renal. A paciente do caso 3, apesar dos sintomas e sinais de comprometimento respiratorio...
Subject(s)
Adolescent , Adult , Animals , Humans , Male , Female , Crotalid Venoms/adverse effects , Respiratory Insufficiency/etiology , Acute Disease , Acute Kidney Injury/etiology , Crotoxin/adverse effects , Time FactorsABSTRACT
Three patients presented respiratory abnormalities following Crotalus durissus snakebite. These abnormalities appeared in the first 48 h after the snake bite and consisted of dyspnea, tachypnea, use of accessory muscles of respiration (cases 1 and 2) and flaring of the nostrils (case 2). Cases 1 and 2 developed acute respiratory failure. Case 2, 24 h after the snakebite presented difficult breathing and periods of apnea. He was intubated in the emergency room and transferred to the intensive case unit where he arrive with spontaneous breathing. His respiratory pattern worsened and measurement of arterial pH and blood gases showed metabolic and respiratory acidosis with partial carbon dioxide pressure increasing from 40 to 50.3 mmHg compatible with acute ventilatory failure. Both patients needed mechanical ventilation. Weaning from the ventilator was accomplished after 33 days in case 1 and after 15 days in case 2. Both patients also presented acute renal failure treated with peritoneal dialysis with full recovery of the renal function. Measurements of forced vital capacity (FVC) and forced expiratory volume in the first second (FEV 1.0) was carried out 58 hours after the snakebite in case 3. Both FVC and FEV 1.0 were reduced in relation to the predicted values (60 and 67% respectively) but the ratio FEV 1.0/FVC was in the normal range. These findings were compatible with a restrictive pattern of ventilatory failure. Serial measurements showed progressive increase of both FVC and FEV 1.0 reaching 72 and 79% of the predicted values, respectively, in the 10th day after the snakebite.(ABSTRACT TRUNCATED AT 250 WORDS)
