ABSTRACT
The search for new therapeutic strategies against cancer has favored the emergence of rationally designed treatments. These treatments have focused on attacking cell plasticity mechanisms to block the transformation of epithelial cells into cancerous cells. The aim of these approaches was to control particularly lethal cancers such as hepatocellular carcinoma. However, they have not been able to control the progression of cancer for unknown reasons. Facing this scenario, emerging areas such as systems biology propose using engineering principles to design and optimize cancer treatments. Beyond the possibilities that this approach might offer, it is necessary to know whether its implementation at a clinical level is viable or not. Therefore, in this paper, we will review the engineering principles that could be applied to rationally design strategies against hepatocellular carcinoma, and discuss whether the necessary elements exist to implement them. In particular, we will emphasize whether these engineering principles could be applied to fight hepatocellular carcinoma.
ABSTRACT
Room-temperature sodium-sulfur batteries have attracted wide interest due to their high energy density and high natural abundance. Polysulfide dissolution and irreversible Na2S conversion are challenges to achieving high battery performance. Herein, we utilize a metal-organic framework-derived Co-containing nitrogen-doped porous carbon (CoNC) as a catalytic sulfur cathode host. A concentrated sodium electrolyte based on sodium bis(fluorosulfonyl)imide, dimethoxyethane, and bis(2,2,2-trifluoroethyl) ether is used to mitigate polysulfide dissolution. We tune the amount of Co present in the CoNC carbon host by acid washing. Significant improvement in reversible sulfur conversion and capacity retention is observed with a higher Co content in CoNC, with 600 mAh g-1 and 77% capacity retention for CoNC and 261 mAh g-1 and 56% capacity retention for acid-washed CoNC at cycle 50 at 80 mAh g-1. Post-mortem X-ray photoelectron spectroscopy, transmission electron microscopy, and selected area electron diffraction suggest that CoS is formed during cycling in place of Co nanoparticles and CoN4 sites. Raman spectroscopy suggests that CoS exhibits a catalytic effect on the oxidation of Na2S. Our findings provide insights into understanding the role Co-based catalysts play in sulfur batteries.
ABSTRACT
Human cytochrome P450 1A1 (hCYP1A1) has been an object of study due to its role in precarcinogen metabolism; for this reason it is relevant to know more in depth the mechanisms that rule out its expression and activity, which make this enzyme a target for the development of novel chemiopreventive agents. The aim of this work is to review the origin, regulation, and structural and functional characteristics of CYP1A1 letting us understand its role in the bioactivation of precarcinogen and the consequences of its modulation in other physiological processes, as well as guide us in the study of this important protein.
