Mucoceles of the anterior ventral surface of the tongue and the glands of Blandin-Nuhn: 5 cases.

INTRODUCTION: Mucoceles are cystic diseases of the oral mucosa. The most common are ranula and mococeles of the lower lip. Blandin and Nuhn mucoceles, which develop at the ventral side of the tongue, are rare benign lesions. They are often misdiagnosed and sometimes confused with ranula. The recommended treatment is a complete surgical excision of the gland. PATIENTS AND METHODS: We describe 5 clinical cases managed in service between 2009 and 2016. Clinical cases are presented in order to detail their clinical history, paraclinical and treatment. RESULTS: The clinical appearance is a longitudinal swelling of the ventral surface of the tongue, parallel to the frenulum. The volume of the swelling is variable; it is normally around 30 × 10 mm. The paraclinical (ultrasound, CT, MRI, or ponction) could be performed. CT showed an cyst located on the ventral surface of the tongue, with liquid density. Blandin and Nunh mucocele were strictly anechogenic. MRI confirms the liquid content of this cyst (low T1signal, high T2signal and no post-contrast-enhanced). The resection of Blandin and Nuhn glands should respect the sublingual gland, the lingual nerve and the lingual veins in the mouth floor. CONCLUSION: This study demonstrates that Blandin and Nuhn mucoceles must be understood and recognised to propose complete excision of the Blandin and Nuhn gland and avoid recurrence.

Efficacy of toltrazuril (Baycox 5% suspension) in natural infections with pathogenic Eimeria spp. in housed lambs.

A field study was conducted to evaluate the effect of a single oral treatment with 20 mg/kg body weight (BW) of toltrazuril (Baycox 5% suspension)--TOL--in comparison to a single oral treatment with 1 mg/kg BW of diclazuril (Vecoxan suspension orale, 2.5 mg/ml)--DIC--and an untreated control group (CTRL) on naturally acquired Eimeria infections in lambs. On a French sheep farm with a known history of coccidiosis, 75 housed lambs aged 10-14 days were randomised and allocated to one of three groups. During an observation period of 60 days after treatment, clinical (faecal consistency, BW) and parasitological parameters (oocyst excretion) were evaluated. Excretion in the negative control group started 3 days after treatment and peaked on the 31st day with a prevalence of 80%. Animals were predominantly infected with Eimeria ovinoidalis. Treatment with toltrazuril, but not with diclazuril, resulted in significantly reduced numbers of excreting animals. The number of excretion days and the average oocyst excretion decreased significantly in both the TOL and the DIC groups compared to the CTRL, with the TOL group showing significantly fewer excretion days and excretion intensities than the DIC group. Changes in the faecal consistency were moderate throughout the study and not significantly different between the groups. Daily weight gains were higher in the TOL group compared to the DIC and CTRL groups which did not differ. This study demonstrates the good efficacy of toltrazuril administered orally to lambs in the prepatent period in subclinical natural Eimeria infections in housed lambs.

Fasciola hepatica and Paramphistomum daubneyi: field observations on the transport and outcome of floating metacercariae in running water.

Experimental investigations in eight open drainage ditches and furrows from central France were carried out to analyse the dispersal of floating metacercariae of two digenean species by running water and to determine the outcome of larvae which settled on Nasturtium officinale (watercress). The frequencies of larvae found after their transport by water ranged from 33% to 49.7%, thus indicating that more than half of the metacercariae used in this experiment had fallen to the bottom of the water during this transport. The nature of the site (furrow, or ditch supplied by a spring) had a significant effect on the distribution of floating larvae, while the digenean species had no effect. Low percentages of metacercariae on watercress were noted in furrows (3.5-4.3% of larvae) and ditches (0.8-1.3%). When the watercress grew, most larvae that had settled on leaves and stems died but there were always several living metacercariae on this plant (0.7-1.5% of larvae for Fasciola hepatica and 0.2-0.5% for Paramphistomum daubneyi). The weak buoyancy of these floating cysts on running water limited their dispersal and, consequently, led to a real diminution of risks incurred by definitive hosts towards these metacercariae.

Helminth intensity and diversity in organic meat sheep farms in centre of France.

A helminthological study was undertaken at five sheep meat organic farms in the centre of France. The data obtained were compared with two extensive (contemporary of present study) or semi-intensive (literature data) conventional sheep meat farms. The nematode fauna of the region could be characterised by the presence of Trichostrongylus axei alongside with the dominant species recorded in other areas (Teladorsagia circumcincta and Trichostrongylus colubriformis with few Haemonchus contortus). The average intensity of infection was slightly less than 7000 worms in the digestive-tract; infection was on average higher in organic farms, although one organic farm had very low infection. This high intensity could be due to the lower frequency of anthelmintic treatments in these farms. Species/genera diversity was much higher in organic farms. Diversity was positively correlated to the area of pastures available and to the reduction of the number of treatment of ewes.

Pharmacokinetics of eprinomectin in plasma and milk following topical administration to lactating dairy cattle.

The pharmacokinetics and mammary excretion of eprinomectin were determined in cattle following topical administration at a dose rate of 0.5 mg kg(-1). The kinetics of plasma and milk concentrations were analysed using a one-compartment model. The maximum plasma concentration of 43.76 ng ml(-1)occurred 2.02 days post administration, and the mean residence time was 4.16 days. Eprinomection was detected in the milk at the first sampling time and thereafter for at least 15 days. Comparison of the milk and plasma data demonstrated the parallel disposition of the drug in the milk and plasma with a milk / plasma concentration ratio of 0. 102+/-0.048. The amount of drug recovered in the milk during this period was 0.109% +/- 0.038 of the total administered dose. This very low extent of mammary excretion resulted in low concentrations of eprinomectin in milk. This supports the permitted use in lactating cattle, as the maximum level of residue in milk did not exceed the maximum acceptable limit of 30 ng ml(-1).

Economic benefits of prophylaxis with diclazuril against subclinical coccidiosis in lambs reared indoors.

One hundred and twenty weaned male lambs, naturally infected with Eimeria species, were used to assess the economic benefits of the prophylactic administration of diclazuril. They were randomly divided into four groups of 30 lambs on the basis of their bodyweight and output of oocysts. The groups were either left untreated (group 1), treated orally with a simple dose of diclazuril at 1 mg/kg (group 2), with two doses two weeks apart (group 3), or with sulphadimethoxine at 50 mg/kg for five consecutive days (group 4). No clinical signs of coccidiosis were observed in any of the groups. The output of oocysts was significantly reduced on day 7 after treatment in group 2, on days 7, 14 and 28 in group 3 and on days 7 and 14 in group 4. No significant differences were found between the treated and untreated groups for bodyweight, carcase weight and carcase classification. The mean fattening period was shorter for the treated lambs (52 and 55 days) than for the untreated controls (60 days). The average growth rate of the lambs treated twice with diclazuril and with sulphadimethoxine was improved and the feed conversion rates of the lambs treated once or twice with diclazuril were 7 per cent and 16 per cent better than that of the untreated lambs.

Immunological detection of chemotherapeutic success in bovine fasciolosis using the specific antigen f2.

An improved hemagglutination (HA) test using the purified specific f2 antigen of Fasciola hepatica has been evaluated with regard to its potential use for the prediction of chemotherapeutic success in natural bovine infections with F. hepatica. Lactating cows (n = 16) from a herd naturally infected with F. hepatica were successively treated with nitroxynil (Dovenix, Specia) and with oxyclozanide (Zanil, ICI) 1 month later. Their f2-specific antibodies were significantly lower than those of a non-treated control group (n = 15) from the second month after the first treatment, and continued to decline thereafter to negative values 5-6 months post-treatment. In a second experiment, culled and fattened cows (n = 32) of unknown fasciolosis history were treated with closantel (Janssen Pharmaceutica). Three months after treatment, f2-specific antibodies of the serologically positive animals (n = 24) were reduced nine-fold. In contrast, in the control group (n = 28), the titers of f2-specific antibodies of the serologically positive animals (n = 21) were not modified significantly. The results show that the f2-HA test is useful for the prediction of chemotherapeutic success in bovine fascioliasis.

Early immunodiagnosis of bovine fascioliasis using the specific antigen f2 in a passive hemagglutination test.

An improved hemagglutination (HA) test using the purified specific f2 antigen of Fasciola hepatica has been evaluated with regard to its potential use for early diagnosis of infection. On experimental infection of beef calves 6-8 months of age, f2-specific antibodies were detected 2-4 weeks after inoculation and persisted at high levels during the 28 week experimental period. On natural infection of dairy calves, 6-9 months of age, allowed to graze in infected fields from April to June, 48% of the animals were positive in July although coproscopic analyses were negative. In November all the calves were HA positive but only 24% of them excreted F. hepatica eggs. Beef calves 1-3 months of age allowed to graze with their dams in infected fields continued to suckle their dams and were weakly infected according to HA results. This weak infection was not detected by coproscopical analysis. Colostral f2-specific antibodies persisted for approximately 6 months in the serum of dairy calves allowed to suckle their dams immediately after birth.

Major internal parasites interfering with cattle production in France, and experiments to control them by strategic treatments. A bibliographic review.

A summary of the cattle management systems and statistics in France is presented as a framework to examine the recently published results on the major internal parasites of cattle in France from numeric data on naturally infested animals. From these results the major or constant parasites are Fasciola, Dictyocaulus, Ostertagia and Cooperia; occasional but important parasites are Nematodirus, Neoascaris, Eimeria, OEsophagostomum and Cysticercus bovis. Pathology results focus on disease given by the most common nematode : Ostertagiasis. For prevention and control of infestations in farm practice with typical management procedures, results are presented in dairy cattle (Brittany and Normandy), and in beef cattle (Limousin).

[Abnormalities of the aortic arches discovered at bronchography in children with bronchial disorders (author's transl)]. / Anomalies des arcs aortiques découvertes au cours de bronchographies chez l'enfant bronchopathe

In four children, aged respectively 2, 6, 8 and 11 years, an abnormality of the aortic arches was discovered fortuitously during bronchoscopy. The latter was carried out in an attempt to assess bronchial lesions in children suffering from chronic or recurrent bronchopneumonia. The authors stress the importance of careful examination of the mediastinum in such cases, the diagnosis of the causal vascular abnormality (double aortic arch in all four cases) being possible by simple radiological examinations with no element of aggression.