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1.
Chromosome Res ; 6(4): 255-62, 1998 Jun.
Article in English | MEDLINE | ID: mdl-9688514

ABSTRACT

Cytogenetic studies were performed in four species of two scorpaeniform teleost families: Scorpaenidae and Triglidae. The karyotypes of Trigla lucerna, Trigloporus lastoviza (Triglidae), Scorpaena porcus and S. notata (Scorpaenidae) were analysed using various banding methods and in situ hybridization with a telomeric probe. In the two Scorpaena species, modest morphological divergence corresponded to considerable karyotype reorganization, while in the two Triglidae substantial phenotypical divergence corresponded to limited chromosomal changes. These data stress the need for a taxonomical re-evaluation of these teleosts based on characters independent of morphology.


Subject(s)
Chromosome Banding , Fishes/genetics , Animals , Bromodeoxyuridine , Chromosome Inversion , DNA Restriction Enzymes , Evolution, Molecular , Fishes/classification , Genetic Variation , Heterochromatin , In Situ Hybridization, Fluorescence , Karyotyping , Kidney , Nucleolus Organizer Region , S Phase , Telomere
2.
Boll Soc Ital Biol Sper ; 59(8): 1070-5, 1983 Aug 30.
Article in English | MEDLINE | ID: mdl-6226304

ABSTRACT

"Paranormal" variants of human chromosomes, devoid of phenotypical effects (since what appears to vary is heterochromatic, non-genic DNA) are known to be heritable. Some very large variants (especially the qh+ variants on chromosomes 1 and possibly 16 and Y) were reported to be associated with increased reproductive pathology (sterility, fetal wastage, chromosomal aberrations). These variants are currently assessed by the C-band techniques; very large C-bands correspond to morphological alterations (elongation or deformation) of the chromosome. A study of qh+ morphological variants of chromosomes 1, 9 and 16 in 40 professionally radioexposed subjects, in 40 Down-syndrome patients and in 40 controls is reported, indicating that the frequency of each variant is lowest among controls, intermediate among professionally radioexposed subjects and highest among Down-syndrome patients. These findings, if confirmed, suggest a possible use of the qh+ variants as heritable indicators of chromosomal damage.


Subject(s)
Chromosome Aberrations , Down Syndrome/genetics , Radiology , Chromosome Banding , Chromosomes, Human, 1-3 , Chromosomes, Human, 16-18 , Chromosomes, Human, 6-12 and X , Environmental Exposure , Humans , Male , Personnel, Hospital , Y Chromosome
3.
Boll Soc Ital Biol Sper ; 57(4): 351-4, 1981 Feb 28.
Article in Italian | MEDLINE | ID: mdl-7195264

ABSTRACT

The frequency of the 9qh+ variant was fond to be significantly increased (as compared to controls) in the following classes of subjects: R)professionally radioexposed individuals; P)patients with chromosomal aberrations; PP)parents of P; Cs)sterile or pluriabortive couples. While the increase of 9qh+ in P and PP individuals was already known, the findings in professionally radioexposed individuals and sterile or pluriabortive couples appear to be relatively new. Occurrence of 9qh+ might prove to be a useful indicator of chromosomal damage, while confirmation of these findings would entail stringent limitation of professional and diagnostic radioexposure.


Subject(s)
Abortion, Habitual/etiology , Chromosome Aberrations , Chromosomes, Human, 6-12 and X , Chromosomes/radiation effects , Infertility/etiology , Radiation Effects , Environmental Exposure , Female , Humans , Male , Pregnancy , Radiation Genetics
4.
Boll Soc Ital Biol Sper ; 56(6): 549-55, 1980 Mar 30.
Article in Italian | MEDLINE | ID: mdl-7378188

ABSTRACT

The "qh+" variants in the human karyotype are generally held to be inherited and devoid of phenotypical effects, although more frequent in families with cases of chromosomal aberrations. The finding of an even higher frequency of apparent mosaicism for 9qh+ in the karyotype of individuals professionally exposed to radiation supports the hypothesis that the variant may be mutagen-induced, possibly reflecting a "first hit" in chromosomal damage. Further studies are under way to verify the hypothesis, in view of a possible use as an indicator of radiation damage and/or risk factor in genetic counseling.


Subject(s)
Chromosome Aberrations , Chromosomes, Human, 1-3 , Chromosomes, Human, 16-18 , Chromosomes, Human, 6-12 and X , Occupational Diseases , Radiation Injuries , Humans
6.
Acta Genet Med Gemellol (Roma) ; 24(3-4): 311-3, 1975.
Article in English | MEDLINE | ID: mdl-1235937

ABSTRACT

A case of "G2 Deletion Syndrome" is reported, based on concordant cytogenetic, clinical and dermatoglyphic findings. The definition if the syndrome, as associated with either a ring or a partially deleted chromosome 22, is discussed. The resulting interpretation favours the hypotheses of deletion of the short arm extending into the centromere.


Subject(s)
Chromosome Aberrations/genetics , Chromosome Deletion , Chromosome Disorders , Chromosomes, Human, 21-22 and Y , Dermatoglyphics , Ear/abnormalities , Female , Humans , Karyotyping , Sex Characteristics , Syndrome
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