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3.
Arch Intern Med ; 155(20): 2202-6, 1995 Nov 13.
Article in English | MEDLINE | ID: mdl-7487242

ABSTRACT

BACKGROUND: The wider use of written advance directives is popular but problematic. We have shown previously that acute hospitalization in the era of the Patient Self-Determination Act can facilitate directive discussions and documentation. We investigated whether a simple educational intervention following hospitalization would increase patients' execution of durable health care proxies. METHODS: We studied a consecutive series of patients (n = 162) recently discharged from the acute care medical service of a community hospital where they had been interviewed about advance directives. The intervention group was randomized to receive an educational brochure and encouragement to execute durable health care proxies. The primary outcome was the proportion of patients in each group with completed durable health care proxies on file in their primary physicians' offices. RESULTS: Overall, only 20 (12.3%) of 162 patients had documented proxies, 17 of whom (85%) were 65 years of age or older, with no difference between the intervention and control groups (11 [13.3%] of 83 vs nine [11.4%] of 79, respectively). Subgroup analysis of elderly patients also revealed no intervention effect. Univariate analysis revealed three significant predictors of patients' proxy completion: patient age, whether patients had discussed directives in hospital with their physicians, and whether patients' physicians completed proxies for themselves. Multiple logistic regression analysis showed that these three variables interact to predict the probability of patients' executing proxies. CONCLUSIONS: Simple educational interventions, like those mandated by the Patient Self-Determination Act, are unlikely to increase patients' completion of durable healthcare proxies. Multidimensional interventions that target both elderly patients and their personal physicians should be tested in the future. Discussion in hospital about advance directives can be a useful component of such efforts.


Subject(s)
Advance Directives , Hospitalization , Patient Education as Topic , Physician's Role , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Female , Hospitals, Community , Humans , Logistic Models , Male , Middle Aged
4.
Arch Intern Med ; 155(21): 2317-23, 1995 Nov 27.
Article in English | MEDLINE | ID: mdl-7487256

ABSTRACT

BACKGROUND: Hospitalization presents an opportunity for physicians to discuss advance directives with patients and to encourage completion of health care proxies. OBJECTIVE: To prospectively promote discussion and documentation of treatment-specific directives about life-sustaining interventions (cardiopulmonary resuscitation, admission to critical care units, mechanical ventilation, electrical cardioversion, and vasopressor therapy) among unselected medical inpatients in a community teaching hospital. METHODS: We conducted a time-series intervention trial from January 1, 1991, through June 30 1993, divided into three phases. During the education phase, we provided reminders, education, and feedback to attending physicians; during the intervention phase, we promoted a new documentation form for directives to be used by attending physicians; during the control phase, no interventions occurred. We studied consecutive patients (N = 1780) admitted to the hospital acute medical service in each of the following 10 periods: three in the education phase (n = 598), three in the intervention phase (n = 826), and four in the control phase (n = 356). The primary outcome measures were the frequency and content of directives documented by attending physicians in their patients' hospital charts. Secondary outcome measures included physicians' and patients' attitudes about directives, surveyed repeatedly. RESULTS: The proportion of inpatients with directives increased significantly during the intervention phase (62.5% vs 23.6% during the education phase and 25.3% during the control period, P < .001, Pearson chi 2 test). During the final intervention phase, 227 (83.2%) of 273 inpatients had directives documented in the hospital chart. Increases in clinically important ("impact") directives usually involved intensive care, not do-not-resuscitate status. Overall, 366 (86.7%) of 422 physician-attested directives agreed with the treatment preferences of interviewed patients (kappa ranges, 0.53 to 0.79). Physicians' attitudes about and interest in directives improved. CONCLUSIONS: Institutional interventions can facilitate attending physicians' documentation of treatment-specific directives about life-sustaining care for most medical inpatients. More research is needed to confirm the effect of these efforts on quality and cost of hospital care, patients' autonomy, and their eventual execution of durable directives and proxies.


Subject(s)
Advance Care Planning , Advance Directives , Hospitals, Community , Hospitals, Teaching , Patient Education as Topic/organization & administration , Aged , Attitude to Health , Documentation , Health Knowledge, Attitudes, Practice , Humans , Medical Staff, Hospital/education , Medical Staff, Hospital/psychology , Middle Aged , Organizational Policy , Outcome Assessment, Health Care , Prospective Studies , Records
5.
Arch Intern Med ; 154(20): 2299-308, 1994 Oct 24.
Article in English | MEDLINE | ID: mdl-7944852

ABSTRACT

BACKGROUND: The attitudes of hospitalized patients and their attending physicians about advance directives have not been well studied. We compared these attitudes and explored relationships between them and the frequency of actual directives and directive discussions during hospitalization. METHODS: We conducted scripted interviews with 258 (94.5%) of 273 patients admitted consecutively to the acute medical service of a community teaching hospital in Rochester, NY, and contemporaneously surveyed their attending physicians (n = 68) regarding attitudes about advance directives. Primary outcome measures were patients' willingness to discuss directives, actual physician-patient directive discussions, and patients' preferences for life-sustaining treatments. Also measured were physicians' indications for directive discussions, their reasons not to discuss directives, and their knowledge and attitudes about life-sustaining treatments. RESULTS: Eighty-one percent (172/212) of competent interviewed patients either did (100) or wanted to (72) discuss advance directives in hospital. Forty-one percent of patients chose to forgo cardiopulmonary resuscitation; 24% to 41% refused other life-sustaining interventions (intensive care unit admission, mechanical ventilation, cardioversion, vasopressors). Overall, 90% (246/273) of all patients met at least one of three criteria reported by their physicians as indications for advance directive discussions: age at least 75 years, critical or potentially fatal illness, and patients' desire to discuss directives. Multiple logistic regression revealed that these same variables predicted patients' willingness to discuss cardiopulmonary resuscitation, their preferences to receive or forgo cardiopulmonary resuscitation, and the frequency of physician-patient discussions about these issues. CONCLUSIONS: Most medical inpatients in a community hospital want to, are able to, and meet their own physicians' indications to discuss advance directives. Hospitalization presents an unrealized opportunity for physicians and patients to initiate these discussions.


Subject(s)
Advance Directives , Attitude to Death , Hospitals, Community , Physician-Patient Relations , Adolescent , Adult , Aged , Aged, 80 and over , Cardiopulmonary Resuscitation , Communication , Disclosure , Female , Humans , Inpatients , Interviews as Topic , Logistic Models , Male , Middle Aged , New York , Prospective Studies , Surveys and Questionnaires , Withholding Treatment
6.
J Urol ; 149(6): 1530-1, 1993 Jun.
Article in English | MEDLINE | ID: mdl-8501804

ABSTRACT

Perinephric abscess is an uncommon urinary tract infection that usually is caused by Staphylococcus aureus as a single pathogen or gram-negative bacilli as part of a polymicrobial process. We describe a man who presented with a right perinephric abscess due to coagulase-negative Staphylococcus as the only pathogen. The patient had bilateral nephrolithiasis, and he was treated successfully with percutaneous drainage of the abscess and parenteral antibiotics. Coagulase-negative staphylococci are increasingly reported to cause serious infections. This organism can no longer be routinely dismissed as a contaminant or colonizer. Repeated isolation of coagulase-negative Staphylococcus in the absence of other pathogens must be considered a high risk situation.


Subject(s)
Abscess/microbiology , Acute Kidney Injury/etiology , Kidney Diseases/microbiology , Staphylococcal Infections/epidemiology , Abscess/epidemiology , Aged , Humans , Kidney Diseases/complications , Male , Staphylococcal Infections/microbiology
9.
Am J Infect Control ; 16(6): 241-5, 1988 Dec.
Article in English | MEDLINE | ID: mdl-3264666

ABSTRACT

Enterococcal infections consistently account for approximately 10% of all nosocomial infections reported to the Centers for Disease Control. There is concern that an increase in nosocomial enterococcal infection is due to the increased severity of inpatient illnesses and to the widespread use of broad-spectrum beta-lactam antibiotics. Nosocomial enterococcal infections were analyzed at our medium-sized community hospital over a time period spanning 9 years. A significant increase in the infection rate was detected during the latter half of 1986. This increase was due primarily to a disproportionate rise in the incidence of the urinary tract as a site of infection. There were no associated clusters of infection, no predilection for certain patient care areas, and no preceding change in the hospital infection control policies and procedures. Total hospital use of cephalosporins remained stable during the period of increased enterococcal infections, but use of third-generation cephalosporins almost doubled in 1986 compared with the 4 preceding years. Selective pressure of third-generation cephalosporin use appeared to be a factor in the increased incidence of nosocomial enterococcal urinary tract infection.


Subject(s)
Cephalosporins/therapeutic use , Cross Infection/epidemiology , Hospitals, Community , Streptococcal Infections/epidemiology , Aged , Cohort Studies , Drug Resistance, Microbial , Female , Hospital Bed Capacity, 100 to 299 , Humans , Male , New York , Risk Factors , Urinary Tract Infections/epidemiology
10.
Arch Intern Med ; 144(9): 1755-7, 1984 Sep.
Article in English | MEDLINE | ID: mdl-6476992

ABSTRACT

A prospective analysis of patients hospitalized with pneumococcal infection at two Rochester (NY) hospitals was performed during an 18-month period to assess the feasibility of a pneumococcal vaccination program directed at inpatients. Of the 113 patients hospitalized with pneumococcal infection, only nine patients (8%) had previously received pneumococcal vaccine and 76 patients (67%) had been hospitalized at least once in the previous three years. Of the 104 patients who had a source of regular medical care, 100% had made at least one outpatient visit in the previous three years. The association between the acquisition of a serious pneumococcal infection and hospitalization within the previous three years suggests that a vaccination strategy directed at hospitalized high-risk patients would be potentially effective. Also, vaccination of high-risk ambulatory patients remains a viable strategy to prevent serious pneumococcal infection.


Subject(s)
Bacterial Vaccines , Immunization , Pneumococcal Infections/prevention & control , Adolescent , Adult , Aged , Feasibility Studies , Female , Hospitals, University , Humans , Male , Middle Aged , New York , Outpatient Clinics, Hospital , Prospective Studies , Streptococcus pneumoniae/immunology
11.
Infect Control ; 5(2): 88-92, 1984 Feb.
Article in English | MEDLINE | ID: mdl-6559770

ABSTRACT

The epidemiology of endemic gentamicin- and tobramycin-resistant gram-negative bacilli at a community hospital was analyzed over a one-year period three years following an original analysis at the same hospital. The frequency and distribution of resistant organisms remained stable over the time spanning the two studies. Only 2.8% of all gram-negative bacilli were resistant to gentamicin or tobramycin, and the majority of resistant isolates were non-Enterobacteriaceae. The respiratory and urinary tracts remained the body sites most prone to harbor resistant organisms. Risk analysis using a matched comparison group again revealed prior treatment with an aminoglycoside to be the only significant factor pre-disposing to acquisition of resistant gram-negative bacilli. This analysis indicates that community hospitals may not be important reservoirs of endemic aminoglycoside-resistant gram-negative bacilli, and reconfirms the observation that each hospital must define its own pattern of aminoglycoside resistance and unique risk factors.


Subject(s)
Acinetobacter/isolation & purification , Bacterial Infections/microbiology , Carrier State/microbiology , Cross Infection/microbiology , Enterobacteriaceae/isolation & purification , Pseudomonas/isolation & purification , Acinetobacter/drug effects , Drug Resistance, Microbial , Enterobacteriaceae/drug effects , Gentamicins/therapeutic use , Hospitals, Community , Humans , Longitudinal Studies , New York , Pseudomonas/drug effects , Tobramycin/therapeutic use
12.
Respiration ; 46(4): 379-81, 1984.
Article in English | MEDLINE | ID: mdl-6395241

ABSTRACT

To our knowledge, Haemophilus parainfluenzae lung abscess has not been described previously. Such a case is presented in the setting of diabetes mellitus. The implications of diagnosis and management are discussed.


Subject(s)
Haemophilus Infections/diagnosis , Lung Abscess/diagnosis , Adult , Bacteriological Techniques , Diabetes Mellitus, Type 2/complications , Humans , Male
13.
Respiration ; 44(2): 153-7, 1983.
Article in English | MEDLINE | ID: mdl-6836191

ABSTRACT

The most common forms of Listeria monocytogenes infection in adults are meningitis-encephalitis and sepsis. Infection of the pulmonary parenchyma and pleura have rarely been reported. A case of listeria meningitis presenting with pleural space infection in an immunosuppressed patient is presented and a review of 5 additional patients with listeria infection of the respiratory tract is included. All 6 patients described in this report had L. monocytogenes infections presenting with respiratory tract symptomatology, although 4 patients subsequently had positive blood or cerebrospinal fluid cultures. It is emphasized that a culture report of 'diphtheroids' from a thoracentesis specimen should not be automatically dismissed as contamination, particularly in an immune compromised patient.


Subject(s)
Listeriosis/physiopathology , Lung Diseases/physiopathology , Pleural Diseases/physiopathology , Humans , Listeriosis/complications , Lung Diseases/complications , Lung Diseases/microbiology , Male , Middle Aged , Pleural Diseases/complications , Pleural Diseases/microbiology , Pleural Effusion/complications
14.
Antimicrob Agents Chemother ; 22(1): 154-6, 1982 Jul.
Article in English | MEDLINE | ID: mdl-6289736

ABSTRACT

All aminoglycoside-resistant gram-negative bacilli isolated during 1 year at a community hospital were tested for in vitro sensitivity to cefotaxime, moxalactam, cefoperazone, and piperacillin. The majority of Enterobacteriaceae were susceptible to all four antibiotics. Cefoperazone and piperacillin were the most active for pseudomonas aeruginosa, and activity for other nonfermentative gram-negative bacilli was variable.


Subject(s)
Anti-Bacterial Agents/pharmacology , Bacteria/drug effects , Cross Infection/microbiology , Aminoglycosides/pharmacology , Cefoperazone , Cefotaxime/pharmacology , Cephalosporins/pharmacology , Cephamycins/pharmacology , Humans , Moxalactam , Penicillin Resistance , Penicillins/pharmacology , Piperacillin
15.
Am J Clin Pathol ; 77(6): 758-61, 1982 Jun.
Article in English | MEDLINE | ID: mdl-7046419

ABSTRACT

Two different methods of processing blood cultures were compared at a community hospital. A day three "blind" subculture and five days of observation for visible growth was used during one year (Phase I), compared with a day five "blind" subculture and seven days of observation for visible growth during the second twelve-month period (Phase II). Phase II was not associated with an increased number of probable pathogens isolated from blood cultures, compared with the earlier "blind" subculture and shorter observation for visible growth used during Phase I. Instead, the later "blind" subculture and longer observation for visible growth yielded a significantly greater number of probable blood culture contaminants. Recommendations for processing of blood cultures developed at referral centers may not be applicable to community hospitals, and the timing of "blind" subcultures and duration of observation for visible growth should be based on the unique patient population characteristics of each hospital.


Subject(s)
Bacteria/isolation & purification , Bacteriological Techniques , Blood/microbiology , Hospitals, Community , Humans
19.
J Clin Microbiol ; 12(5): 690-4, 1980 Nov.
Article in English | MEDLINE | ID: mdl-7024300

ABSTRACT

Aberrant filamentous forms of Escherichia coli were observed on direct Gram stain of blood cultures from a patient being treated with the beta-lactam antibiotic cephalexin. After the institution of an alternative antibiotic regimen which included a different cell wall-active agent, E. coli of normal morphology was detected in blood cultures for an additional 48 h. Filamentous forms of E. coli could be reproduced reliably in vitro by incubating the organism in Mueller-Hinton broth containing various concentrations of cephalexin. Both supra- and subinhibitory concentrations of cephalexin resulted in filament formation after 4 h of incubation, whereas 24 h of incubation yielded intact filaments at only a narrow range of subinhibitory concentrations of cephalexin. In vitro comparison of the ability of cephalexin, cephalothin, ampicillin, and gentamicin to cause filamentous forms of E. coli showed that cephalexin and cephalothin produced pure filament formation after 4 h of incubation at subinhibitory concentrations of as low as one-fourth the minimum inhibitory concentration of the antibiotic. Ampicillin was not associated with pure filament formation at concentrations below the minimum inhibitory concentration, and gentamicin produced no filaments at any concentration. The effect of preincubation of E. coli with subinhibitory concentrations of cephalexin on subsequent minimum inhibitory concentrations of ampicillin was examined in an effort to develop an explanation for the persistent sepsis exhibited by the patient. No diminution of the activity of ampicillin by preincubation with cephalexin could be demonstrated. Other possible clinical implications of filamentous forms of gram-negative bacilli are discussed.


Subject(s)
Cephalexin/pharmacology , Escherichia coli Infections/microbiology , Escherichia coli/cytology , Sepsis/microbiology , Ampicillin/pharmacology , Cephalexin/therapeutic use , Cephalothin/pharmacology , Escherichia coli/drug effects , Gentamicins/pharmacology , Humans , Male , Middle Aged
20.
Infect Control ; 1(4): 249-52, 1980.
Article in English | MEDLINE | ID: mdl-6905816

ABSTRACT

The incidence and spectrum of resistance to gentamicin and tobramycin among gram-negative bacilli (GNB) isolated in a community hospital over a one-year period were studied. The overall incidence of resistance was 3.7%. Pseudomonads constituted almost half of the resistant organisms. The majority of resistant GNB was isolated from the respiratory and urinary tracts. Acquisition of resistance was correlated with both the total use of gentamicin in the hospital and recent treatment of individual patients with gentamicin plus tobramycin. The overall incidence of resistant isolates (3.7%) and the incidence of resistance for the enterobacteriaceae (1.9%) were lower than rates reported by comparable studies at several university or municipal hospitals.


Subject(s)
Anti-Bacterial Agents/pharmacology , Bacteria/isolation & purification , Gentamicins/pharmacology , Hospitals, Community , Tobramycin/pharmacology , Aged , Bacteria/drug effects , Drug Resistance, Microbial , Drug Utilization , Enterobacteriaceae/drug effects , Enterobacteriaceae/isolation & purification , Female , Hospital Bed Capacity, 100 to 299 , Humans , Male , New York
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