ABSTRACT
Pharmacokinetic interactions involving the cytochrome P450 system have been a recent focus of clinical and research interest in psychopharmacology. The authors reviewed 100 consecutive patients seen on a consultation-liaison (C-L) psychiatry service for potential drug-drug interactions. The patients were taking a mean of 8.8 medications; for those undergoing organ transplantation the mean was 12.9. While both enzyme inhibitors (n = 87) and substrates (n = 89) were commonly used, only rarely were they used in the same patient (n = 14). The authors conclude that the potential for drug interactions on a C-L psychiatry service is significant, necessitating awareness of this potential complication.
Subject(s)
Cytochrome P-450 Enzyme Inhibitors , Mental Disorders/drug therapy , Organ Transplantation/psychology , Patient Care Team , Psychotropic Drugs/adverse effects , Cytochrome P-450 Enzyme System/physiology , Drug Interactions , Drug Therapy, Combination , Enzyme Inhibitors/administration & dosage , Enzyme Inhibitors/adverse effects , Enzyme Inhibitors/pharmacokinetics , Humans , Mental Disorders/blood , Mental Disorders/psychology , Psychotropic Drugs/administration & dosage , Psychotropic Drugs/pharmacokinetics , Risk FactorsABSTRACT
The Work Group on the Education of the Health Professions and the Nation's Health offers the theme of discontinuity to describe why so little useful knowledge has been derived from research in this area and to suggest a more productive approach for future studies. Discontinuities are evident among the needs of patients and populations and how dentists practice and in what dentists do in practice versus the content of dental education. The Work Group recommends six areas directly applicable to dentistry in which research might alleviate these discontinuities.
Subject(s)
Education, Dental , Public Policy , Research , Culture , Dental Care , Economics, Dental , Oral Health , Preventive Dentistry , Professional Practice/economics , United StatesABSTRACT
The Work Group on the Education of the Health Professions and the Nation's Health offers the theme of discontinuity to describe who so little useful knowledge has been derived from research in this area and to suggest a more productive approach for future studies. Discontinuities are evident amoung the needs of patients and populations and how professionals practice what is taught in professional schools. The work group recommends seven areas for study in the expectation that new information might alleviate these discontinuities.
