ABSTRACT
Describimos un caso de flegmasia cerulea dolens secundaria a una trombosis venosa profunda por compresión de la vena cava inferior, en un varón de 31 años con un tumor germinal. Necesitó un tratamiento urgente con agentes fibrinolíticos, heparina intravenosa y quimioterapia. Con el tratamiento obtuvo una respuesta completa tumoral y una completa revascularización de la vena cava y vena femoral derecha
We describe a case of phlegmasia cerulea dolens secondary to venous thrombosis due to compression of inferior vena cava, in a 31-year-old man with a germ cell tumour. He was treated with systemic thrombolytic agents, intravenous heparin and urgent chemotherapy He presented a complete tumoral response and complete revascularization of the vena cava and right femoral vein
Subject(s)
Male , Adult , Humans , Thrombophlebitis/complications , Testicular Neoplasms/complications , Femoral Vein/physiopathology , Vena Cava, Inferior/physiopathology , Thrombolytic Therapy , Heparin/therapeutic useABSTRACT
We describe a case of phlegmasia cerulea dolens secondary to venous thrombosis due to compression of inferior vena cava, in a 31-year-old man with a germ cell tumour. He was treated with systemic thrombolytic agents, intravenous heparin and urgent chemotherapy He presented a complete tumoral response and complete revascularization of the vena cava and right femoral vein.
Subject(s)
Neoplasms, Germ Cell and Embryonal/complications , Testicular Neoplasms/complications , Thrombophlebitis/etiology , Vena Cava, Inferior , Venous Thrombosis/etiology , Adult , Humans , Male , Neoplasms, Germ Cell and Embryonal/drug therapy , Testicular Neoplasms/drug therapyABSTRACT
Like other pneumonias due to atypical agents, pneumonia due to Legionela Pneumophila has no characteristic clinical facts, although fever and non-productive cough are almost constant and diarrhea with changes in mental status are common. Hyponatremia and moderate transient hypertransaminasemia are common too. Severe systemic affectation after hematogenous dissemination similar to those described with typical bacterial pneumonias is a prominent difference with other atypical agents, with high mortality rates in the absence of appropriate treatment. Etiological diagnosis is very difficult and it is normally achieved late in the course of the infection. Because of diagnostic difficulties and potential mortality in predisposed patients, empirical antibiotherapy has been extensively recommended. We present a patient affected by critical community-acquired pneumonia due to Legionela Pneumophila serogroup 1 with liver alteration as the main manifestation and good response to empirical antibiotherapy with claritromycine and rifampin. We recommended the empirical use of such therapy in those pneumonias without microbiological diagnosis and torpid evolution.
Subject(s)
Legionnaires' Disease/complications , Liver Diseases/microbiology , Humans , Male , Middle AgedABSTRACT
Al igual que con el resto de gérmenes atípicos, son escasos los rasgos de presentación sugestivos de neumonía por Legionella Pneumophila, si bien es casi constante la presencia de fiebre con tos seca y frecuentes la diarrea y afectación del sensorio. Analíticamente es común el hallazgo de hiponatremia e hipertransaminasemia moderada. A diferencia de otros gérmenes atípicos, Legionella Pneumophila presenta diseminación hematógena con afectación sistémica grave más propia de gérmenes típicos y elevada mortalidad sin tratamiento adecuado. El diagnóstico etiológico es difícil y suele alcanzarse tardíamente. Lo dificultoso y tardío del diagnóstico etiológico y la potencial gravedad en pacientes predispuestos aconsejan la antibioterapia empírica. Presentamos un caso de neumonía comunitaria grave por Legionella Pneumophila serogrupo 1 con afectación hepática como manifestación principal y buena respuesta a la antibioterapia empírica con claritromicina y rifampicina. Recomendamos el uso empírico de esta antibioterapia en aquellos procesos neumónicos sin diagnóstico microbiológico y evolución tórpida (AU)