Incidence and Predictors of Lateral Hinge Fractures Following Medial Opening-Wedge High Tibial Osteotomy Using Locking Plate System: Better Performance of Computed Tomography Scans.

BACKGROUND: This study compared the rates of plain radiographs and computed tomography (CT) for detecting lateral hinge fractures and to evaluate factors affecting lateral hinge fractures in patients following medial opening-wedge high tibial osteotomy (MOWHTO). METHODS: This prospective study included 59 patients (65 knees) undergoing MOWHTO for primary medial compartment osteoarthritis with a 2-year follow-up between 2013 and 2016. Clinical and radiographic evaluations were performed using Knee Society Score and Western Ontario and McMaster Universities Arthritis Index, and we calculated the hip-knee-ankle angle, weight-bearing line ratio, lateral distal femoral angle, medial proximal tibial angle, posterior tibial slope, osteotomy gap height, and osteotomy gap filling rate. Immediate plain radiographs and CT were used to detect lateral hinge fractures according to Takeuchi's method. RESULTS: Among 65 knees, the incidence of lateral hinge fractures was 13.8% (Type I: 7, Type II: 2). Only 6 knee fractures (9.2%) were detected on postoperative plain radiographs, including 5 Type I fractures and 1 Type II fracture. An additional 3 knees (4.6%) were detected on postoperative CT scans, including 2 Type I fractures and 1 Type II fracture. Furthermore, osteotomy gap height (adjusted odds ratio = 1.831, P = .016) was the only predictor of lateral hinge fractures. CONCLUSION: The incidence of lateral hinge fractures after MOWHTO was 13.8%. CT (13.8%) afforded higher detection rates for lateral hinge fractures than did plain radiographs (9.2%) despite a marginal difference with uncertain significance. Osteotomy gap height was the only predictor of lateral hinge fractures. LEVEL OF EVIDENCE: Prospective cohort study (Level II).

Enhancing milk and fertility performances using selection index developed for Indian Murrah buffaloes.

Selection for genetically superior Murrah buffaloes under Network Project on Buffalo Improvement, India, is presently based on milk yield, and it was observed that even in the absence of any direct selection pressure applied on fertility, there has been a downward trend in fertility associated with the selection for milk yield. The aim of the study was to develop selection indices which include fertility besides milk yield in Murrah buffaloes. Data pertaining to 1,224 lactation records spread over a period of 19 years were recorded and analyzed in the study. The negative association of pregnancy rate (fertility) with a 305-day milk yield (-0.08 ± 0.04) and wet average (-0.12 ± 0.02) indicated the importance of incorporating fertility trait in the construction of selection index. Four types of selection indices were constructed and evaluated. Two indices were developed using expected producing ability 305-days milk yield (EPAMY) with 6.5 and 4% fat in milk along with expected fertilizing ability (EFA). The other two indices developed consist of expected producing ability wet average (EPA WA) and EFA. The index involving (EPA WA and EFA) was found to be a more effective selection criterion in our herd, as the accuracy of index was more (0.61), in comparison to the index involving EPA MY and EFA. The robustness of selection index was assessed by increasing the relative economic values of included traits by 25 and 50%, and accuracy of the index remains almost stable without much change. The developed selection strategy involving EPA WA and EFA should be considered for the genetic evaluation of Murrah buffaloes, as it has a potential for maximizing the lifetime reproduction and production performances of the breed.

The photochemical C2-C6 cyclization of enyne-allenes: interception of the fulvene diradical with a radical clock ring opening.

The mechanism of the photochemical C(2)-C(6) cyclization of enyne-allenes has been studied through radical clock, intramolecular kinetic isotope effect, and laser flash photolysis (LFP) experiments as well as density functional theory (DFT) and ab initio computations. While the photochemical cyclization of enyne-allenes 1 and 2 furnished ene and Diels-Alder products without any cyclopropyl ring opening, that of 3 carrying the ultrafast diphenylcyclopropylcarbinyl radical clock afforded products derived from cyclopropyl ring opening. Laser flash photolysis (LFP) studies on enyne-allene 3 point to an allene triplet excited state (transient A) as a primarily formed short-lived (tau = 430 ns) intermediate. In addition, we have obtained evidence for the formation of a diphenylmethyl-type diradical (transient C, tau = 1.0 micros) resulting from ring opening of a diphenylcyclopropane ring. C subsequently undergoes a surprisingly slow (tau = 1.0 micros) 1,6-hydrogen shift leading to the stable 1,3-diene 6.

Photochemical C2-C6 cyclization of enyne-allenes: detection of a fulvene triplet diradical in the laser flash photolysis.

A series of enyne-allenes, with and without benzannulation at the ene moiety and equipped with aromatic and carbonyl groups as internal triplet sensitizer units at the allene terminus, was synthesized. Both sets, the cyclohexenyne-allenes and benzenyne-allenes, underwent thermal C(2)-C(6) cyclization exclusively to formal ene products. In contrast, the photochemical C(2)-C(6) cyclization of enyne-allenes provided formal Diels-Alder and/or ene products, with higher yields for the benzannulated systems. A raise of the temperature in the photochemical cyclization of enyne-allene 1b' led to increasing amounts of the ene product in relation to that of the formal Diels-Alder product. Laser flash photolysis at 266 and 355 nm as well as triplet quenching studies for 1b,b' indicated that the C(2)-C(6) cyclization proceeds via the triplet manifold. On the basis of a density functional theory (DFT) study, a short-lived transient (tau = 30 ns) was assigned as a triplet allene, while a long-lived transient (tau = 33 micros) insensitive to oxygen was assigned as fulvene triplet diradical. An elucidation of the reaction mechanism using extensive DFT computations allowed rationalization of the experimental product ratio and its temperature dependence.

Thermal C2-C6 cyclization of enyne-allenes. Experimental evidence for a stepwise mechanism and for an unusual thermal silyl shift.

Enyne-allenes 4a-c bearing various cyclopropyl systems as radical clock reporter groups at the allene terminus have been synthesized and subjected to thermal C2-C6 cyclization. The ratio of ene versus formal Diels-Alder products could be rationalized on the basis of steric effects. Only the thermolysis of 4c, equipped with the fast diphenylcyclopropylcarbinyl radical clock, afforded a 1,3-butadienyl benzofulvene clearly formed via cyclopropyl ring opening. This finding provides unambiguous evidence for a stepwise mechanism of the C2-C6 cyclization making it possible to suggest a lifetime for the intermediate diradical of >1x10(-10) s (at 170 degrees C). An interesting corollary was the isolation of an unexpected silyl shift product in the thermolysis of all three enyne-allenes that allows explanation of the loss of the TIPS group in some of the Diels-Alder products. For a full understanding of the mechanism, silyl and hydrogen shift processes were interrogated using DFT.

Photochemical myers-saito and C2-C6 cyclizations of enyne-allenes: direct detection of intermediates in solution.

Several examples of the photochemical Myers-Saito and C2-C6 cyclization of enyne-allenes are described. The presence of a triplet sensitizing unit at the allene terminus and laser flash photolysis results suggest that the cyclization proceeds along the triplet manifold. An intermediate with tau = 33 +/- 5 mus was tentatively assigned to a singlet biradical.