ABSTRACT
We compared the implantation and pregnancy rate through in vitro fertilization (IVF) using hyaluronic acid and albumin as transfer medium in 60 women randomly allocated to 2 groups. In treatment group A (n = 30), embryos were transferred to medium supplemented with hyaluronic acid. In the control group B (n = 30), embryos were transferred to medium containing albumin. There were no significant differences between the groups in terms of mean age of the females, mean duration of infertility and mean number of embryos. The pregnancy rate in groups A and B were 81.8% and 71.4% respectively, a non-statistically significant difference. Hyaluronic acid can successfully replace albumin as transfer medium.
Subject(s)
Albumins , Culture Media , Embryo Transfer , Fertilization in Vitro/methods , Hyaluronic Acid , Pregnancy Outcome/epidemiology , Abortion, Spontaneous/epidemiology , Adult , Albumins/standards , Analysis of Variance , Chi-Square Distribution , Culture Media/standards , Double-Blind Method , Embryo Implantation , Embryo Transfer/standards , Female , Humans , Hyaluronic Acid/standards , Infertility, Female/therapy , Iran/epidemiology , Maternal Age , Ovulation Induction/methods , Patient Selection , Pregnancy , Prospective Studies , Time FactorsABSTRACT
We compared the implantation and pregnancy rate through in vitro fertilization [IVF] using hyaluronic acid and albumin as transfer medium in 60 women randomly allocated to 2 groups. In treatment group A [n = 30], embryos were transferred to medium supplemented with hyaluronic acid. In the control group B [n = 30], embryos were transferred to medium containing albumin. There were no significant differences between the groups in terms of mean age of the females, mean duration of infertility and mean number of embryos. The pregnancy rate in groups A and B were 81.8% and 71.4% respectively, a non-statistically significant difference. Hyaluronic acid can successfully replace albumin as transfer medium
Subject(s)
Hyaluronic Acid , Albumins , Pregnancy Rate , Culture Media , Embryo TransferABSTRACT
OBJECTIVE: To compare the result of IUI in infertile couples with different protocols of induction ovulation. METHODS: In a retrospective study, 209 infertile couples with different diagnosis (unexplained, male factor, endometriosis, tubal disease, ovulatory dysfunction and multifactorial infertility) were subjected to different protocol of induction ovulation: 50-100 mg CC in day 2-6, 50 mg CC in day 2-6 + 2 amp HMG in day 5, 7, 9, 11, and 2 amp HMG per day. Natural ovulatory cycle + IUI was used for sperm stored patients. 441 consecutive cycles of IUI was performed 36-40 hours after HCG injection. The data were analysed with student T-test and Mann-Whitney test. The significance was defined as P<0.005. RESULTS: Thirty one pregnancies (7% per cycle, 15% per patient) occurred. One pregnancy occurred (pregnancy per cycle was 2% and per patient was 12%) in 8 patients undergoing 37 cycles of IUI with natural ovulation. The result with CC in 27 patients undergoing 41 cycles IUI was 2 pregnancies (4% per cycle, 7% per patient). In 129 patients receiving 283 cycles of IUI with CC+HMG 21 pregnancies occurred (7% per cycle, 16% per patient). In 35 patients receiving 80 cycles of IUI with HMG 8 pregnancies occurred (9% per cycle, 23% per patient). CONCLUSION: The method chosen for ovulation induction had a critical bearing on the success of IUI. The result of IUI will be better by using induction ovulation compared to natural ovulatory cycle. In our programme the combined use of HMG+IUI yielded a higher rate of pregnancy rate compared with CC+IUI, CC+HMG+IUI and natural ovulatory cycle+IUI.
