Investigation of the inclusion complex of ß-cyclodextrin with mycophenolate mofetil.

The acid-base equilibrium of mycophenolate mofetil is studied in the absence and presence of ß-cyclodextrin (ß-CD). The conditional acidity constants are obtained by rank annihilation factor analysis (RAFA) as a function of ß-CD concentrations. Also the stability constants for inclusion complexes of ß-CD with both acidic and basic forms are calculated. The conditional acidity constant decreases by increasing ß-CD concentration. The calculated stability constants show that the acidic form of mycophenolate mofetil forms more stable inclusion complex (552±7 M(-1)) than its basic anionic form (158±2 M(-1)).