Assessment of sexual dimorphism using 3D CBCT image data among Indians.

It is of interest to investigate the use of frontal sinus morphology, bizygomatic and intermaxillary distance for the determination of gender using Cone-Beam Computer Tomography (CBCT). The study population consisted of 75 subjects (35 females and 40 males) with a mean age of 39.25 years (range: 20-70 years), of ethnic group of south-Indian based population. The data was categorized into three age groups of 20-35, 36-50 and ≥ 50 years. All the features and measurements are recorded for each case using CBCT images that were acquired with a CBCT scanner (Planmeca Mid Proface Cone Beam 3D, Helsinki Finland). The data were subjected to a discriminant functional analysis, compared and statistically analyzed. No two persons had the same measurements. Statistically significant differences were found in the frequency of overall metric parameters between the two genders (P < 0.05) except intermaxillary distance (P = -0.034) respectively. These data provide a valuable tool in differentiating gender. It should be noted that bizygomatic distance can significantly improve the gender determination using discriminant analysis. Cone beam computed tomography is a safe procedure with minimal radiation exposure proved to be highly accurate in sinus imaging and provide irreplaceable and precise information about frontal sinus and the whole skull. Measurements showed significant difference except intermaxillary distance and intersinus width among the three age groups. The discriminant analysis showed that the ability of frontal sinus parameters and bizygomatic distance to identify gender with high accuracy.

Novel alkynyl substituted 3,4-dihydropyrimidin-2(1H)-one derivatives as potential inhibitors of chorismate mutase.

A series of novel alkynyl substituted 3,4-dihydropyrimidin-2(1H)-one (DHPM) derivatives were designed, synthesized and evaluated in vitro as potential inhibitors of chorismate mutase (CM). All these compounds were prepared via a multi-component reaction (MCR) involving sequential I2-mediated Biginelli reaction followed by Cu-free Sonogashira coupling. Some of them showed promising inhibitory activities when tested at 30µM. One compound showed dose dependent inhibition of CM with IC50 value of 14.76±0.54µM indicating o-alkynylphenyl substituted DHPM as a new scaffold for the discovery of promising inhibitors of CM.

Accuracy of estimation of dental age in comparison with chronological age in Indian population--a comparative analysis of two formulas.

UNLABELLED: Demirjian's 8-teeth method widens the assessment in a wider age group, in comparison with the original 7-teeth method. AIM AND OBJECTIVE: Evaluate age in children, adolescents and young adults using Demirjian's 8-Teeth Method in an Indian population. Compare the effectiveness of existing Demirjian's formula with that of the Indian formula. MATERIALS AND METHOD: Panoramic radiographs of 50 male and 50 female patients aged between 5 and 24 years were collected. The radiographs were interpreted using Demirjian's 8-teeth method and the dental age calculated using Demirjian's formula and the Indian formula. Both the formula's were compared using paired 't' test (SPSS Statistics 11.5). RESULTS: Among the 100 samples the mean chronological age in 50 males was 13.44 years and mean chronological age in 50 females was 13.12 years. By using Demirjian's formula the mean dental age in male was 11.81 years and that in female was 11.58 years. By using Indian Formula the mean dental age in male was 13.54 years and that in female was 14.06 years. The mean dental age by both the formulas were compared with the corresponding chronological age. It was evaluated that the Demirjian's formula underestimated the mean dental age by 1.63 years in males and by 1.54 years in females, whereas a variation of 0.10 years in male and 0.94 years in female was found with the Indian formula. The mean dental age obtained using Indian formula was approximating with the chronological age in the male and female by a margin of 0.94 years. CONCLUSION: Acharya's Indian formula is more effective in evaluating the dental age closer to the chronological age of an individual in an Indian population in comparison with the existing Demirjian's formula.

Oral health status of 5 years and 12 years school going children in Chennai city--an epidemiological study.

India, a developing country, faces many challenges in rendering oral health needs. The majority of Indian population resides in rural areas of which more than 40% constitute children. The purpose of this study was to assess the oral health status of 5 years and 12 years school going children in Chennai city. The study population consisted of 1200 school children of both the sexes (600 private and 600 corporation school children) in 30 schools, which had been selected randomly. The survey is based on WHO, 1999 Oral Health Assessment, which has been modified by including gingival assessment, enamel opacities/ hypoplasia for 5 years. Evaluation of the oral health status of these children revealed, dental caries is the most prevalent disease affecting permanent teeth, more than primary teeth and more in corporation than in private schools, thereby, correlating with the socioeconomic status. It may be concluded that the greatest need of dental health education is at an early age including proper instruction of oral hygiene practices and school based preventive programs, which would help in improving preventive dental behaviour and attitude which is beneficial for life time.

Constituents of Cassia auriculata.

The isolation and spectral data of di-(2-ethyl) hexyl phthalate (1) from Cassia auriculata leaves are reported.