ABSTRACT
Eczema is a common skin disease associated with inflammation. Interleukin (IL)-24 is crucial in the pathogenesis of inflammatory diseases like eczema. The study objective was the assessment of IL-24 serum levels and its gene polymorphisms in eczematic Iraqi patients. This retrospective case-control study involved 145 participants, divided into 82 patients with eczema and 63 healthy controls. An enzyme-linked immunosorbent assay measured serum IL-24, while polymerase chain reaction and Sanger DNA sequencing were used for genotype analysis. Serum IL-24 level was significantly higher (P valueâ <â .001) in patients compared to controls (41.6 [interquartile range (IQR): 28.9-53.6] vs 9.8 [IQR: 0.8-19.6] pg/mL, respectively). DNA sequence illustrated 2 SNPs with polymorphic frequencies (rs1150256 G/A and rs3093425 del/ins). The first SNP (rs1150256 G/A) showed 3 genotypes (GG, AA, and G/A), while the second SNP (rs3093425) showed 3 genotypes (-/G del/Ins, G Ins/Ins, and - del/del). The subsequent investigation revealed the presence of the following findings within the DNA sequence of the PCR amplified region (329bp). In the control group, all participants had GG/G (wild type) genotype/allele for the rs1150256 SNP, while in eczematic patients, 24.4% GG, 50% GA, and 25.6% AA. For the second SNP genotype (rs3093425 del/ins), the genotype frequencies in patients vs control were (24.4% vs 84.1%, 50.0% vs 11.1%, and 25.6% vs 4.8; Del/Del, Del/Ins, and Ins/Ins, respectively). The presence of Ins compared to Del increased the risk of eczema by 8.91 (4.66-17.03); OR (95% CI). In conclusion, IL-24 is a good predictor of eczema and A-allele carrier for rs1150256 SNP, and insertion-allele carrier for rs3093425 SNP is associated with elevated serum IL-24 and higher risk of eczema.
Subject(s)
Eczema , Interleukins , Polymorphism, Single Nucleotide , Humans , Interleukins/genetics , Interleukins/blood , Iraq , Male , Female , Retrospective Studies , Case-Control Studies , Eczema/genetics , Eczema/blood , Adult , Genotype , Genetic Predisposition to Disease , Adolescent , Young AdultABSTRACT
An all-fiber magnetic field sensor based on whispering-gallery modes (WGM) in a fiber micro-resonator infiltrated with ferronematic liquid crystal is proposed and experimentally demonstrated. The cylindrical microresonator is formed by a 1 cm-long section of a photonic crystal fiber infiltrated with ferronematic materials. Both ferronematics suspensions are prepared based on the nematic liquid crystal 1-(trans-4-Hexylcyclohexyl)-4-isothiocyanatobenzene (6CHBT) doped with rod-like magnetic particles in the first case and with spherical magnetic particles in the second case. WGMs are excited in the fiber microresonator by evanescent light coupling using a tapered fiber with a micron-size diameter. The Q-factor of the microresonator determined from the experimentaly measured transmission spectrum of the tapered fiber was 1.975 × 103. Under the influence of an applied magnetic field the WGM resonances experience spectral shift towards shorter wavelengths. The experimentally demonstrated sensitivity of the proposed sensor was -39.6 pm/mT and -37.3 pm/mT for samples infiltrated with rod like and spherical like ferromagnetic suspensions respectively for a magnetic field range (0-47) mT. Reducing the diameter of the cylindrical micro-resonator by tapering leads to enhancement of the magnetic field sensitivity up to -61.86 pm/mT and -49.88 pm/mT for samples infiltrated with rod like and spherical like ferromagnetic suspensions respectively for the magnetic field range (0-44.7) mT.
ABSTRACT
In this work, a magnetic-field sensor was designed to take advantage of the tunability of the resonance wavelengths of a cylindrical whispering-gallery-mode microresonator. The microresonator is based on a 1.3 cm length of photonic crystal fiber infiltrated with a magnetic fluid containing nanoparticles with diameters of either 5 or 10 nm. The Q-factor achieved for the microresonators was 4.24×10(3) or higher. When a magnetic field is applied, the whispering-gallery-mode resonances shift toward longer wavelengths. The experimentally demonstrated sensitivity of the proposed sensor was as high as 110 pm/mT in the magnetic field range from 0 to 38.7 mT.
