Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
ChemMedChem ; 12(20): 1677-1686, 2017 10 20.
Article in English | MEDLINE | ID: mdl-28881465

ABSTRACT

Since the discovery of WNK mutations that cause an inherited form of hypertension in humans, there has been increasing interest in targeting WNK signaling as a novel strategy for modulating blood pressure. This notion is now supported by numerous mouse models with impaired WNK signaling that exhibit reduced blood pressure. Biochemical analyses of the various protein components that make up this signaling pathway have identified a number of plausible molecular targets that are amenable to targeting by small molecules. To date, a selection of small-molecule WNK signaling inhibitors have been identified and have shown promise in suppressing the activity of WNK signaling in cells and in animals. In this Minireview, we briefly discuss the WNK signaling pathway and provide an overview of the various druggable targets within this cascade, as well as the different WNK signaling inhibitors discovered to date.


Subject(s)
Antihypertensive Agents/therapeutic use , Hypertension/drug therapy , Protein Serine-Threonine Kinases/antagonists & inhibitors , Signal Transduction/drug effects , Humans
SELECTION OF CITATIONS
SEARCH DETAIL
...