1.
The kinetics and molecular modeling of the complexation of tenoxicam with cyclodextrins in solution.
Spectrochim Acta A Mol Biomol Spectrosc
; 71(2): 562-5, 2008 Nov 15.
Article
in English
| MEDLINE
| ID: mdl-18289928
ABSTRACT
The effect of cyclodextrins on photodegradation of tenoxicam (TEN) was studied at pH 4, 7 and 10. After 60 min of irradiation with UV light, the photodegradation was extensive. All cyclodextrins (alpha, beta, or gamma) stabilize TEN and reduce the rate of photodegradation. The largest effect of cyclodextrins is at pH 7. Molecular modeling results help to explain and manipulate the results. The results are discussed and compared with other results from previous studies.