ABSTRACT
BACKGROUND: Surgical removal of impacted mandibular third molaris one of the most common procedures performed by Oral surgeons globally. The objective of the study was to ascertain theefficacyof pre-operative administration of submucosal dexamethasone on post-operative sequelae insurgically extracted impactedmandibular third molar.It was adouble-blind randomized controlled clinical trialthat wasperformed inthe Department of Oral & Maxillofacial Surgery at Abbottabad International Dental Hospital, Abbottabad from March 2019 to March 2020. METHODS: A total of 150 patientsweredivided into two groups,each having 75 patients. Group A received a placebo after administrationof local anesthesia whereas,group B received 4mg submucosaldexamethasone. A post-operative visit was scheduled after 48 hours to evaluate pain, facial swelling,and Trismus. RESULTS: On the second postoperative day, the patients in the experimental group presented with significantly reduced pain, facial swelling,and trismus in comparison to the control group. CONCLUSION: Pre-operativeadministration of 4mg dexamethasone through the submucosal route is efficacious inthe reduction of post-operative pain, swelling,and trismus in mandibular third molarsurgerythus enabling the patient to return to daily life activities earlier.