ABSTRACT
We reported a case of a 65-year-old male who had been treated with obinutuzumab and chemotherapy for follicular lymphoma. He was infected with SARS-CoV-2 after the second course of therapy. He developed fever, cough and bilateral pulmonary infiltrates. His nasopharyngeal swab became negative only temporarily after repeated courses of antiviral therapy, and the symptoms and pulmonary infiltrates waxed and waned. He presented to our hospital with exertional dyspnea and hypoxemia after his nasopharyngeal swab was positive for SARS-CoV-2 for the fourth time. He had an elevated serum lactate dehydrogenase and a positive 1, 3-ß-D-glucan test. The PCR test for Pneumocystis jirovecii in the sputum was positive. The patient was diagnosed with persistent COVID-19 and Pneumocystis jirovecii pneumonia. He responded well to the combination treatment of antiviral medication, convalescent plasma, trimethoprim-sulfamethoxazole and corticosteroids.
Subject(s)
Lymphoma, Follicular , Male , Humans , Aged , Dyspnea , Fever , Cough , Antiviral AgentsABSTRACT
A 28-year-old male with a history of leukopenia was admitted with complaints of fever, cough, and dyspnea for 3 months. Initial work-up identified reduced circulating levels of granulocytes, monocytes, lymphocytes, and NK cells. Computed tomography revealed bilateral reticulonodular opacities and mediastinal lymph node enlargement. Peripheral blood culture and mediastinal lymph node aspiration yielded Mycobacterium avium. Genetic testing revealed a heterozygous germline GATA2 mutation (c.1187G>A, R396Q). Despite standard anti-mycobacterial therapy, the patient's dyspnea worsened and subsequent imaging studies revealed diffuse ground-glass opacification. A transbronchial lung biopsy confirmed the development of pulmonary alveolar proteinosis. Bone marrow transplantation had not been performed due to the unavailability of suitable donors. The disease progressed after whole lung lavage, and the patient died at the age of 31 years from respiratory failure. The current case report emphasized the importance of raising awareness about the rare GATA2 deficiency, which is characterized by hematologic abnormalities, primary immunodeficiency, and pulmonary alveolar proteinosis.
Subject(s)
Hematopoietic Stem Cell Transplantation , Pulmonary Alveolar Proteinosis , Male , Humans , Adult , Pulmonary Alveolar Proteinosis/genetics , Bronchoalveolar Lavage/methods , Dyspnea/etiology , Nontuberculous Mycobacteria , Hematopoietic Stem Cell Transplantation/adverse effectsABSTRACT
We report the first prenatal diagnosis of a case of congenital mesoblastic nephroma complicated by hydrops fetalis. Congenital mesoblastic nephroma is generally thought to be a benign disease but when complicated by hydrops fetalis it may be a potentially lethal condition.
Subject(s)
Hydrops Fetalis/etiology , Kidney Neoplasms/complications , Nephroma, Mesoblastic/complications , Prenatal Diagnosis/methods , Amniocentesis , Fatal Outcome , Female , Humans , Hydrops Fetalis/diagnosis , Kidney Neoplasms/congenital , Kidney Neoplasms/diagnosis , Nephroma, Mesoblastic/congenital , Nephroma, Mesoblastic/diagnosis , Pregnancy , Pregnancy Trimester, Second , Ultrasonography, PrenatalABSTRACT
Cervical carcinoma spreads predominantly by lymphatic routes and lymph node metastases may occur even in early stages of disease. Metastases usually first appear in pelvic lymph nodes, then disseminate along the efferent lymphatic chain to the extrapelvic lymph nodes. Cases of positive lymph node metastases with negative pelvic nodes in invasive cervical carcinoma are extremely rare. We report a 50-year-old woman with bulky stage IIA cervical carcinoma who had scalene lymph node metastases in the absence of pelvic lymph node metastases after radical hysterectomy and postoperative pelvic irradiation. This rare "skipping" nodal metastasis was probably via posterior trunk lymphatic drainage of the bulky cervical carcinoma which mainly invaded the posterior vaginal cuff. Neoadjuvant or adjuvant chemotherapy is recommended to prolong survival of patients in such cases.
Subject(s)
Carcinoma, Squamous Cell/pathology , Lymph Nodes/pathology , Uterine Cervical Neoplasms/pathology , Female , Humans , Lymphatic Metastasis , Middle Aged , Neck , Neoplasm Invasiveness , PelvisABSTRACT
Malignant fibrous histiocytoma of the broad ligament origin is extremely rare. We report a case of a 64-year-old female with a broad ligament tumor mass, who underwent complete excision of the mass, total hysterectomy, and bilateral salpingo-oophorectomy. Pathology showed a malignant fibrous histiocytoma of the broad ligament. The postoperative course was uneventful and no radiation or chemotherapy was given. She has been carefully monitored for 16 months and is without recurrence.
