ABSTRACT
The present study evaluated the occurrence of HTLV-1 and its subtypes in blood samples of patients presenting symptoms of tropical spastic paraparesis/HTLV-1 associated myelopathy. The detection of HTLV infection was performed by serological and molecular assays. Five patients were infected by HTLV-1 of the Cosmopolitan subtype, subgroup Transcontinental. The results confirm the occurrence of HTLV-1 infection among patients with clinical diagnosis of tropical spastic paraparesis/HTLV-1 associated myelopathy in Belém, Pará.
Subject(s)
Human T-lymphotropic virus 1/genetics , Paraparesis, Tropical Spastic/virology , Sequence Alignment , Base Sequence , DNA, Viral/analysis , Enzyme-Linked Immunosorbent Assay , Humans , Molecular Sequence Data , Paraparesis, Tropical Spastic/diagnosis , Polymerase Chain ReactionABSTRACT
O presente estudo avaliou a ocorrência da infecção pelo HTLV-1 e seus subtipos em amostras de sangue de pacientes com diagnóstico clínico de paraparesia espástica tropical/mielopatia associada ao Htlv-1. A detecção da infecção pelo HTLV realizou-se através de testes sorológico e molecular. Cinco amostras estavam infectadas pelo HTLV-1 do subtipo Cosmopolita, subgrupo Transcontinental. Os resultados obtidos confirmam a ocorrência de infecção pelo HTLV-1 em pacientes com diagnóstico clínico de paraparesia espástica tropical/mielopatia associada ao Htlv-1em Belém, Pará.
The present study evaluated the occurrence of HTLV-1 and its subtypes in blood samples of patients presenting symptoms of tropical spastic paraparesis/HTLV-1 associated myelopathy. The detection of HTLV infection was performed by serological and molecular assays. Five patients were infected by HTLV-1 of the Cosmopolitan subtype, subgroup Transcontinental. The results confirm the occurrence of HTLV-1 infection among patients with clinical diagnosis of tropical spastic paraparesis/HTLV-1 associated myelopathy in Belém, Pará.
Subject(s)
Humans , Human T-lymphotropic virus 1/genetics , Paraparesis, Tropical Spastic/virology , Sequence Alignment , Base Sequence , DNA, Viral , Enzyme-Linked Immunosorbent Assay , Molecular Sequence Data , Polymerase Chain Reaction , Paraparesis, Tropical Spastic/diagnosisABSTRACT
Esta revisão sumária sobre terapêutica em epilepsia aborda questões tais como quando começar o tratamento, qual a droga antiepilética (DAE) indicada para os diversos tipos de crise, quando retirar a DAE, sua posologia, frequência de tomadas, efeitos colaterais e idução/inibição enzimática da DAE, monitorização do tratamento e epilepsia refratária. Várias dessas questões são dependentes do conhecimento de farmacocinética e farmacodinâmica, fatos que também são considerados.