Histological Examination of Tissue Obtained in Early Pregnancy Loss.

Background It is a routine practice to send histological sample after surgical evacuation of early pregnancy loss. Objective This study was carried out to see the justification of regular histological study by carrying out the histological study of early pregnancy loss and to find the prevalence of gestational trophoblastic disease in early pregnancy loss. Method It was a descriptive prospective study, conducted in Nepal medical college teaching hospital from February to October 2020 in Obstetrics and Gynaecology department. Clinical data such as age, parity, gestational age and diagnosis were collected of 130 patient of early pregnancy loss. Then histological study were sent after surgical evacuation. Result Among the age group, 21-30 age group was maximum. (64.61%), more than half of the patient was primigravida (53.07%) and most of the cases were between 6 to 9 weeks of gestation. Incomplete abortions were maximum (43.07%), missed abortions 38.46%, blighted abortions 16.15%, enevitable abortions 1.53% and septic abortion was 0.76%. Among histological finding, 72.30% were product of conception, 15.38% of the cases had no product of conception, decidual tissue only in 6.92%, partial mole in one case (0.76%), complete mole in one case (0.76%) and hydrophic changes in one case (0.76%). The total cases of Gestational trophoblastic diseases (GTD) were 3(2.30%). Conclusion In our study we found 2.3% of cases of GTD, which was quite high in compare to Western word. So it is a good practice to do histological study of all cases of EPL in our country to detect GTD, determining cause for recurrent pregnancy loss and detecting unexpected fetal pathology.

Oral findings in a child with lipoid proteinosis: a case report and review.

Lipoid proteinosis, a very rare autosomal recessive genodermatosis, results in hyaline material deposition in the skin and mucous membrane of various organs leading to multisystem involvement. A case report of a 12-year-old female child is presented here who showed classic features of the disease with generalized thickening, hardening, and scarring of the skin and vocal cord infiltration causing voice changes. The patient also had numerous oral mucosal and dental findings. The knowledge of the clinical features of the disease may help the oral health professional in rendering the appropriate treatment in order to improve the quality of life deteriorated by the disease.

Are dental indexes useful in sex assessment?

This study describes sexual dimorphism in dental indexes derived from the permanent dentition. Three dental indices--'crown area,' 'crown module' and 'crown index'--were calculated from the buccolingual (BL) and mesiodistal (MD) measurements of 123 permanent dentitions (58 females and 65 males) belonging to young Nepalese adults (age-range 19-28 years). Sex differences in the dental indexes were assessed using univariate and multivariate statistics and compared to that of linear measurements reported previously on the same sample. Univariate sex dimorphism exhibited by crown area and crown module was similar to that of linear measurements whereas crown index displayed marked variation. The unusual results shown by the latter is explained as the result of it not being a representation of tooth size per se; rather, crown index is an expression of the difference between BL and MD dimensions and may be better suited as an indicator of tooth 'shape'. Stepwise discriminant analyses undertaken for the indices gave moderate to high accuracy rates in sexing (69.8-81.1%). However, this is lower to the classification accuracy reported for linear measurements. Therefore, it is concluded that dental indexes have no added utility in forensic sex assessment.