ABSTRACT
Introduction: Bariatric surgery is associated with multiple endocrine and metabolic changes. Irisin and nesfatin-1 have recently been described as regulatory peptides involved in obesity-related insulin resistance. Our aim was to analyze the changes of those two molecules observed in patients after bariatric procedures. Materials and methods: This prospective study involved 40 patients treated for morbid obesity. Irisin and nesfatin-1 were measured before, 6 months and 1 year after surgical intervention. We also gathered demographic data, information concerning comorbidities, factors related to the surgery and outcomes of bariatric treatment. Results: Twenty-seven patients completed the study (15 females). The mean age of the group was 43.5 ± 10.4 years. Six (22.2%) patients were submitted to Laparoscopic Sleeve Gastrectomy and 21 (77.8%) patients were submitted to Laparoscopic Roux-en-Y Gastric Bypass. The participants in our study achieved significant weight loss. The irisin level remained stable in the whole study group during all three measurements included in our study protocol (p = .71). Our study group presented a reduction of the nesfatin-1 level 6 months after bariatric surgery and a slight further decrease after one-year observation, although these changes were also not significant (p = .17). Conclusions: We did not find any significant correlation between changes of irisin or nesfatin-1 level and bariatric surgery, as an aid in the regulation of glucose metabolism.
Subject(s)
Fibronectins/blood , Gastrectomy/methods , Gastric Bypass/methods , Nucleobindins/blood , Obesity, Morbid/blood , Obesity, Morbid/surgery , Adult , Female , Glucose/metabolism , Humans , Insulin Resistance/physiology , Laparoscopy , Male , Middle Aged , Prospective StudiesABSTRACT
BACKGROUND: Insulin-like growth factor 1 (IGF-1) is known as somatomedin C. This polypeptide hormone is functionally and structurally similar to insulin. IGF-1 effects on tissue by the IGF-1R and the insulin-like growth factor-binding protein also known as IGFBP. Abnormal IGF-1 and IGFBP signaling are positively correlated with a high risk of selected civilization diseases development. Physical inactivity is a one of the main causes of majority of chronic diseases and it is associated with eg. IGF-1 and IGFBPs level. OBJECTIVE: The aim of the study was to explanation the effect of physical activity on IGF-1 and its binding protein - IGFB- Ps concentration in the context of selected civilization diseases prevention. The review of clinical trial. MATERIAL AND METHODS: The review of articles had published in databases: MEDLINE, EMBASE, Scopus and Web of Science until December 2015. The selected prospective studies about the effect of exercise on IGF-1 level and its binding protein IGFBP in the context of selected civilization diseases prevention were collected. RESULTS: The majority of the included studies indicate that mechanical loading is a key mechanism linking IGF-1/IGFBPs con- centration and selected chronic diseases development. The duration and intensity of physical activity have a significant impact on IGF-1 and IGFBP serum. The highest concentration of IGF-1 in serum was after eccentric training. "Overtraining" increases unfavorable and unbound IGF-1 levels and contributes to the increased incidence of hormone-cancer and osteoarthritis. CONCLUSIONS: Irregularity of the GH/IGF-1 axis may affect on the development of rheumatic diseases, cardiovascular dis- eases (regulate cardiac growth and metabolism) and metabolic syndrome.
