ABSTRACT
Over half (58.4%) of 77 recently diagnosed Chinese HIV infected men having sex with men (MSM) had networked sex partners through Internet in the year prior to their infections. Internet using MSM were younger (29.6y vs 38.7y; t = -4.77, P < 0.01), better educated, more likely to have a regular sex partner, and have undergone regular HIV testing (Chi square = 5.57, P < 0.05). These characteristics could be used for planning public health interventions.
Subject(s)
HIV Infections/transmission , Homosexuality, Male , Internet/statistics & numerical data , Adult , China , Cohort Studies , Data Collection , HIV Infections/prevention & control , Humans , Interpersonal Relations , Male , Middle AgedABSTRACT
We conducted a molecular epidemiological study on newly diagnosed human immunodeficiency virus type 1 (HIV-1)-infected patients in Hong Kong to identify the epidemiological linkage of HIV-1 infection in the locality. Reverse transcription polymerase chain reaction (RT-PCR) for HIV-1 was performed on newly diagnosed HIV-1-positive sera collected from January 2002 to December 2006. PCR products correspond to the env C2V3V4 region and gag p17/p24 junction of the HIV-1 genome were nucleotide sequenced. Phylogenetic analyses performed on the acquired nucleotide sequences revealed that CRF01_AE and subtype B were the two dominant HIV-1 subtypes. Analyses also demonstrated the presence of three emerging HIV-1 clusters among the subtype B sequences in Hong Kong. Individual cluster possesses a unique cluster-specific amino acid signature for identification. Data show that one of the clusters (Cluster I) is rapidly expanding. In addition to the unique cluster-specific amino acid signature, the majority of sequences in Cluster I harbor a 6-amino acid insertion at the gag p17/p24 junction in a region that is thought to be closely associated with HIV-1 infectivity.
