[The characteristics of nitrogen metabolism in the tissues of rabbits with ammonium toxicosis]. / Osobennosti azotistogo obmena v tkaniakh krolikov pri ammoniinom toksikoze.

Disturbances of nitrogen metabolism under acute ammonium toxicosis have been studied in tissues of rabbit. A sharp increase of the ammonium content in the blood and tissues of the liver and kidneys is accompanied by an increase in the glutamine and glutamate level in all tissues. The level of urea nitrogen in the blood of rabbits increases. The activity of phosphate-independent and phosphate-activated glutaminase also increases in tissues of the liver and kidneys, while arginase activity decreases as compared with the control, which is connected with fall of the ATP level under hyperammonemia. A nomograph method of representation of the redox state has been used.

[Acid-base status of the blood and adenine nucleotide metabolism in ruminant erythrocytes during early post-natal development]. / Kislotno-shchelochnoe sostoianie krovi i obmen adeninnukleotidov v éritrotsitakh zhvachnykh v period rannego postnatal'nogo ontogeneza.

It has been established that data of acid-base balance in cows' and newborn calves' blood closely correlate with physiological status of animals during their initial days of postnatal ontogenesis and depend on the peculiarities of metabolism in fetus and newborn organisms. Data on the acid-base balance in blood of newborn calves under diarrhea syndrome are discussed from the point of view of the influence of rehydration therapy and "Namacit" preparation on clinical status of animals.

[Impairment of energy metabolism in rabbit tissues during ammonia toxicosis]. / Narushenie énergeticheskogo obmena v tkaniakh krolika pri ammoniinom toksikoze.

The studies are conducted on the model of grave toxicosis in vivo in rabbits. It is shown that an increase in the ammonia content in blood and tissues enhances the content of lactate, glutamate, oxaloacetate in the liver and kidneys of animals, decreases the level of pyruvate, alpha-ketoglutarate and malate in the liver tissue. The NAD+/NADH ratio in the cytoplasm of the liver and kidney cells decreases, the ratio of NADP-pairs in the cytoplasm and mitochondria of these tissues noticeably increases. The energy metabolism is disturbed sharply, the content of adenosine phosphates lowers.

[Changes in the levels of various substrates of nitrogen metabolism and tricarboxylic acid cycle during experimental acidosis in calves]. / Izmenenie soderzhaniia riada substratov azotistogo obmena i trikarbonovogo tsikla pri éksperimental'nom atsidoze u teliat.

The effect of experimental metabolic acidosis and its correction for nitrogen and energy metabolism was studied in new-born calves. It was discovered that a change in the acid-base balance towards acidosis causes a sharp increase in "ammoniogenesis", urea formation and inhibition of the tricarboxylic acid cycle, which is also observed in calves suffering from dyspepsia with symptoms of acute diarrhea. Alongside with the use of therapeutic measures for treating dyspepsia of new-born calves, it is necessary to control the acid-base balance of blood in the calves and in case of revealing the acidosis state to use means of its correction.