[Antitoxic features of magnesium oxide under combined radiation and thermal injury]. / Antitoksichnye svoistva okisi magniia pri kombinirovannom radiatsionno-termicheskom porazhenii.

Male Wistar rats were exposed to 7.5 Gy total body gamma radiation followed to the additional full-thickness thermal bum. It was shown, that single administration of magnesium oxide in 1 hour after combined injury significantly corrected the early signs of endogenous intoxication. The level of bacterial endotoxemia decreased as well as serum concentration of toxic oligopeptides; general blood serum toxicity has been reduced too. Four-fold magnesium oxide's using as an enterosorbent in combination with antibiotics (doxycyclini, gentamicini or ciprofloxacin) has ensured 73-100% rats survival. All untreated animals dead within 30 days after combined injury.

[Biological preparation based on Lactobacillus acidophilus, a new agent in the early treatment of combined radiation-thermal injuries]. / Biopreparat na osnove Lactobacillus acidophilus--novoe sredstvo rannego lecheniia kombinirovannykh radiatsionno-termicheskikh porazhenii.

Male mice F1 (CBA x C57BL6) were used for experiments. Animals were exposed to 7 Gy gamma-radiation and additionally inflicted to full-thickness thermal burn 10% body surface. As it has been revealed, single subcutaneous injection of the created biopreparation based on inactivated lactobacillus microbic biomass increased mice survival with combined injury from 23% to 73%. Therapeutic efficacy of this remedy did not correlate with postradiation damages of the hemopoietic system. Injection of killed L. acidophilus mixture strikingly averted development of the intestine autoinfection. Possible mechanisms of the benefit therapeutic action of the new preparation are discussed.

[Effects of a synthetic carbon-mineral sorbent and antibiotics on the development of combined radiation and thermal injury]. / Vliianie sinteticheskogo uglerod-mineral'nogo sorbenta (SUMS-1) i antibiotikov na razvitie kombinirovannogo radiatsionno-termicheskogo porazheniia.

Male Wistar rats exposed to whole-body irradiation, the midline absorbed dose was 7.5 Gy. Full-sickness thermal burn 15% of body surface inflicted immediately after irradiation. Experimental study of the therapeutic efficacy of enterosorption alone or in combination with antibiotics doxycycline and ciprofloxacin performed. The strong decrease of bacterial endotoxemia, toxic oligopeptides' level and general blood toxicity revealed after treatment compared with non-treated animals with combined injuries. Corrections of postirradiation intestinal dysbacteriosis revealed too. The best result observed when carbon mineral sorbent and antibiotics administered daily within the first 10-14 days after combined injury. Survival of treated animals increased up to 80% (all rats of control group died during 30 days after combined injury).

[Evaluation of the effectiveness of the use of pefloxacin in combined radiation-thermal injury]. / Otsenka éffektivnosti primeneniia pefloksatsina pri kombinirovannom radiatsionno-termicheskom porazhenii.

The efficacy of pefloxacin, a novel promising antibacterial drug of the group of fluoroquinolones, was studied on mice against doxycycline in the prevention and treatment of infectious complications of radiation/thermal injury. According to the data on the effect of the antibiotics on the resistance to exogenic infection and the development of dysbacteriosis pefloxacin was recommended for the use in the scheme of combined therapy of radiation/thermal injury.

[Experimental rationale for the feasibility of using sulacillin for the prevention of infectious complications of combined radiation and thermal injuries]. / Eksperimental'noe obosnovanie vozmozhnosti primeneniia sulatsillina dlia profilaktiki infektsionnykh ozlozhnenii kombinirovannykh radiatsionno-termicheskikh porazhenii.

Concurrent radiation and thermal injury (IRTI) was simulated in Wistar rats. For prevention of the autoinfectious complications sulacillin, a combination of ampicillin and sulbactam, was used. The use of sulacillin was started on the onset of IRTI and continued for 7 days. The drug was administered intramuscularly twice a day. It was observed that the 8-day survival of the animals increased by more than 40 per cent and the statistical levels of bacteremia and bacterial endotoxemia significantly decreased. The experiments showed that sulacillin had no side immunodepressive effect and did not aggravate the affection of the blood system. The drug was recommended for further studies to provide evidence for rational schemes of antibacterial therapy in IRTI.

[External respiration, pulmonary gas exchange and energy expenditure in weightlessness]. / Vneshnee dykhanie, gazoobmen i energotraty cheloveka v usloviiakh nevesomosti.

This paper summarizes the data on external respiration and energy expenditures of men exposed to zero-g for 185 days and to 1/6 g on the lunar surface reported by Soviet and foreign authors. The paper also discusses factors that may be responsible for a higher level of gas exchange processes at reduced g.