[Experimental estimation of the effect of antibiotics, immobilized on the surface of titanium implant, on the development of the inflammatory process]. / Eksperimental'naia otsenka vliianiia antibiotikov, immobilizovannykh na poverkhnost' titanovogo implantata, na razvitie vospalitel'nogo protsessa.

Titanium implants with immobilized lincomycin and ampicillin were studied on rats with respect to the effect on development of inflammatory reactions. The data on the concentrations of sialic acids in the blood during the postoperative period and the histological examinations showed that lower concentrations of sialic acids, early fibroblastic reaction, productive nature of inflammation in the main and rapid formation of the fibrous connective tissue capsule around the implants were the characteristic features and advantages of the use of the implants with the immobilized antibiotics as compared to the use of the routine titanium implants.

[Immobilization of antibiotics on a titanium surface]. / Immobilizatsiia antibiotikov na poverkhnosti titana.

Immobilization of antibiotics on the surface of electrolytically oxidated titanium was tried. Transfer of the immobilized ampicillin into hardly soluble calcium ampicillate resulted in providing the coating with antimicrobial activity for 5 days. The quantity of the immobilized antibiotic determined polarographically amounted to 6.4.10(-3) mol per 1 m2 of the surface.

[Immobilization of invertase in polyvinyl alcohol coatings]. / Immobilizatsiia invertazy v pokrytie iz polivinilovogo spirta.

A possibility of invertase immobilization in the polyvinyl alcohol coating formed directly on the electrode surface from water solution of polyvinyl alcohol and boric acid was being investigated. Conditions for obtaining the polymeric coating at the constant potential and at the constant current were compared. In order to obtain the polymeric coatings with a marked enzyme activity optimal conditions were found.

[Local anesthetic properties of a polymeric compound of trimecaine]. / Mestoanesteziruiushchie svoistva polimernogo soedineniia trimekaina.

Original techniques were used in experiments on rabbits and rats to explore the activity and duration of a local anesthetic action of a new trimecaine polymer as compared with trimecaine hydrochloride. The polymer effect was found to be 1.5-2 times longer as compared to that of its low-molecular analog, which was discovered in experimental terminal, conduction and infiltration anesthesia in particular. According to the data obtained, the prolongation of the effect of the new drug is determined by slow separation of trimecain from the polymer.