ABSTRACT
Impairment of hemodynamics and metabolism, which is determined by the condition of the hypothalamo--hypophyseal-adrenal system, is very important in the pathogenesis of peritonitis. The cortisol content, the activity of plasma renin, aldosterone, T3 and T4 were studied in 50 patients with diffuse and generalized peritonitis. The regional control group was formed of 50 practically healthy individuals. The patients were examined on the 1st, 3rd, 7th, and 14th postoperative days. The "low T3" syndrome in considerable increase of the content of cortisol, which inhibits the production of triiodothyronine directly, was encountered during the entire postoperative period in patients with peritonitis. Hyporenin hyperaldosteronism occurred on the 7th-14th day, which was evidenced of distorted physiological mechanisms of the production of mineralocorticoids in peritonitis. The hormonal dysbalance in the examined patients was greatest of the 7th postoperative day; the content of the studied hormones was partly normalized by the 14th day.
Subject(s)
Aldosterone/blood , Hydrocortisone/blood , Peritonitis/blood , Renin/blood , Thyroxine/blood , Triiodothyronine/blood , Humans , Peritonitis/etiology , Peritonitis/surgery , Postoperative CareSubject(s)
Cosmic Radiation , Erythrocytes/cytology , Periodicity , Seasons , Sunlight , Adult , Erythrocyte Count/radiation effects , Erythrocytes/radiation effects , Female , Humans , Male , Middle Aged , Sex Factors , USSRABSTRACT
The thermotropic properties of multilamellar liposomes from egg yolk lecithin, hydrogenized egg yolk lecithin and several mixtures of these two lipids were studied with the application of excimer--forming optical probe pyrene and microcalorimetry. It was discovered that when the proportion of the egg yolk lecithin in the lipid mixture was raised the temperature of the main phase transition reduced. For all this, independent of the lipid mixture composition when the temperature was raised, apparently, polarity of pyrene microenvironment in the liposomes bilayers decreased. On the basis of the analysis of solidus and liquidus curves obtained from calorimetric studies of the lipid mixtures and bend points of Arrhenius anamorphose obtained during the pyrene excimer formation measurements some conclusions were made about the role of unmodified and hydrogenized egg yolk lecithin cluster formation in the determination of thermotropic properties of the liposomes from the above two lipids mixtures. High temperature phase transition discovered for the egg yolk lecithin while measuring the pyrene excimer formation is proposed to be closely connected with temperature-dependent changes in the organization of phospholipid heads on the interphase bilayer/H2O solution.
Subject(s)
Egg Yolk , Liposomes , Phosphatidylcholines , Calorimetry , Chemical Phenomena , Chemistry, Physical , Fluorescent Dyes , Pyrenes , Temperature , ThermodynamicsABSTRACT
Persons with risk factors of diabetes mellitus are prone to certain changes in the content of the main classes of immunoglobulins. These changes are aggravated during progression of disease and reflect immunological readjustment of the body playing a certain role in the pathogenesis of diabetes mellitus.
Subject(s)
Diabetes Mellitus/immunology , Immunoglobulins/analysis , Female , Humans , Risk FactorsABSTRACT
The dependence of the turbidity changes at 615 nm monobilayers liposomes from egg yolk lecithin in the presence of bromothymol blue on temperature and storage conditions has been investigated. It is established that the thermotropic properties of liposomes change irregularly and depend on the storage conditions. Sharp release of the bound dye at temperature above 35-37 degrees C is associated with thermotropic change in liposomes and the detected effects, with the change of orientation of the phosphorylcholine group.
