ABSTRACT
Three hundred and fifty children at the age of 3 months to 6 years under diverse social conditions were observed in dynamics for the periods of 1 to 3 years. The main tasks of the study were development of schemes and methods for prophylactic use of the Viferon ointment and estimation of its efficacy in acute viral respiratory tract infection. Season changes in the interferon genesis were revealed and no such dynamics in the children with frequent infections was shown. The ointment was applied according to the developed procedure intranasally in a daily dose of 1 g every day for the first 2 weeks and 3 times a week for the following 2-4 weeks. Interferon correctable and immunomodulating effects of the ointment were detected, the same as its favourable impact on the number of the acute respiratory tract infection cases including those under the conditions of the infant school adaptation. Its favourable effect was also observed in children with frequent infections during their immunorehabilitation. The most pronounced clinical and immunomodulating effects were revealed in young children.
Subject(s)
Antiviral Agents/pharmacokinetics , Ascorbic Acid/pharmacology , Interferon-alpha/pharmacology , Respiratory Tract Infections/prevention & control , Virus Diseases/prevention & control , Vitamin E/pharmacology , Acute Disease , Child , Child, Preschool , Female , Humans , Infant , Interferon alpha-2 , Male , Ointments , Recombinant Proteins , Respiratory Tract Infections/immunology , Retrospective Studies , Virus Diseases/immunologySubject(s)
Carbamates , Enterobiasis/blood , Interferon-alpha/blood , Interferon-gamma/blood , Antinematodal Agents/administration & dosage , Benzimidazoles/administration & dosage , Child , Child, Preschool , Enterobiasis/drug therapy , Humans , Interferon-alpha/drug effects , Interferon-gamma/drug effectsSubject(s)
Child, Preschool , Genetic Diseases, Inborn , Medical History Taking , Morbidity , Acute Disease , Berlin , Humans , MoscowSubject(s)
Health Status , Morbidity , Age Factors , Child, Preschool , Humans , Infant , Moscow , Recurrence , Socioeconomic Factors , Urban PopulationSubject(s)
Child Health Services , Preventive Health Services , Community Health Nursing , Female , Humans , Infant , Infant, Newborn , Pregnancy , Prenatal Care , Russia , Urban PopulationSubject(s)
Lymphocytes/cytology , Child , Child, Preschool , Hematologic Tests/methods , Humans , InfantABSTRACT
The preventive effect of exogenous leukocyte interferon used twice weekly at a 3-day interval in the period of an influenza epidemic as well as the effect of this preparation on the capacity of leukocytes to produce endogenous interferon were studied in young infants brought to nurseries. The observations covered 146 infants varying in ages from 11 months to 31/2 years, of them 104 infants were given interferon intranasally from an automizer (conditional experimental group) and 42 received no interferon (conditional) control group). During the period of interferon prophylaxis (5 weeks) a significant. 7-fold, reduction in the morbidity rate was observed in the group given interferon as compared to the control group. Observations in the time course showed a reduced incidence in the experimental group for a year. During the use of interferon in infants there was an increase in the capacity to produce endogenous interferon as manifested by a significant rise in titres by the end of interferon prophylaxis.
