ABSTRACT
Forty Chinchilla rabbits of both sexes were examined for changes in some parameters of protein, lipid and trace elements metabolism (total protein, protein fractions, urea, residual nitrogen in blood serum, lipids, total cholesterol, free cholesterol, diglycerides, phospholipids, triglycerides, free fatty acids and the trace elements selenium, iron, zinc and so forth in the liver) during the animals' poisoning with the defoliant magnesium chlorate. A study was made of the effect on these changes of the administration for 3 weeks of sodium selenite (15 micrograms/kg), vitamin E (25 mg/kg) and retabolil (2 mg/kg once a week). It has been established that the combined administration of these agents removes and prevents the changes in protein, lipid and trace elements (hypoproteinemia, dysproteinemia and impairment of the nitrous balance) and lipid metabolism because of the animals' poisoning with magnesium chlorate.
Subject(s)
Anabolic Agents/pharmacology , Chlorates/poisoning , Herbicides/poisoning , Magnesium Compounds , Magnesium/poisoning , Nandrolone/analogs & derivatives , Protein Deficiency/chemically induced , Selenium/pharmacology , Vitamin E/pharmacology , Animals , Female , Male , Nandrolone/pharmacology , Nandrolone Decanoate , Protein Deficiency/metabolism , Rabbits , Sodium SeleniteABSTRACT
The effect of sodium selenite, vitamin E, retabolil and their combinations on the content of ATP, creatine phosphate (CP) and inorganic phosphorus in the liver and skeletal muscle was studied in 3 groups of white rats (one- and two-month old and adults). Sodium selenite (30 micrograms/kg), vitamin E (50 mg/kg), retabolil (4 mg/kg) and their combination administered in a single subcutaneous dose for 14 days increased the content of ATP, CP and inorganic phosphorus in the liver and skeletal muscle after these parameters had decreased because of aurantine administration (50 micrograms/kg). Combined use of sodium selenite, vitamin E and retabolil appeared to be most efficacious.