[Complex evaluation of the proliferative activity of tumor cells in different histological variants of lung cancer]. / Kompleksnaia otsenka osobennostei proliferatsii opukholevykh kletok pri razlichnykh gistologicheskikh formakh raka legkogo.

Mitotic regime, labelling index and DNA distribution in malignant lung tumours of different histological types (47 cases) were investigated. The most pronounced proliferative activity in combination with high incidence of three group metaphases and multipolar mitoses of bi- and polyclonal cases of undifferentiated cancer and poorly differentiated squamous cell carcinoma were established. Well-differentiated tumours were monoclonal and usually had a low labelling index. The high incidence of c-mitoses in well-differentiated squamous cell carcinomas is, probably, an evidence for a more pronounced damage of their cell multiplication.

[Proliferation and mitotic performance of lung cancer]. / Issledovanie proliferatsii i mitoticheskogo rezhima raka legkogo.

The mitotic pattern and labeling index of cells in different histological types of lung cancer (29 cases) were investigated. The labeling index of undifferentiated (oat- and small-cell) and poorly-differentiated squamous cell carcinomas is thrice that of moderately- and well-differentiated cancer. Simultaneously, the incidence of K-mitoses in squamous cell carcinoma is 2-2.4 times that of undifferentiated cancer, thus pointing to a relatively more pronounced defectiveness of squamous cancer cells multiplication.

[Effect of the fixation time on tumor mitotic regimen]. / Vliianie vremeni fiksatsii na mitoticheskii rezhim opukholei.

The mitotic regimen of 10 carcinomas from 8 patients was studied. The material was cut and fixed immediately, 1, 2, and 24 hours after the removal of the tumor. The intensity of changes in the mitotic regimen was shown to rise with the increasing length of the period from tumor removal to its fixation. This is likely to be due to partial retention of the capacity of the removed tumor cells to enter mitosis which leads to "accumulation" of dividing cells in the metaphase by the type of K-mitosis.