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Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana.
Modongo, Chawangwa; Barilar, Ivan; Wang, Qiao; Molefi, Tuduetso; Makhondo, Topo; Niemann, Stefan; Shin, Sanghyuk S.
Emerg Infect Dis ; 29(11): 2403-2406, 2023 11.
Article in English | MEDLINE | ID: mdl-37877680

ABSTRACT

GeneXpert MTB/RIF, a tool widely used for diagnosing tuberculosis, has limitations for detecting rifampin resistance in certain variants. We report transmission of a pre-extensively drug-resistant variant in Botswana that went undetected by GeneXpert. The public health impact of misdiagnosis emphasizes the need for comprehensive molecular testing to identify resistance and guide treatment.


Subject(s)
Antibiotics, Antitubercular , Mycobacterium tuberculosis , Tuberculosis, Multidrug-Resistant , Tuberculosis , Humans , Rifampin/pharmacology , Rifampin/therapeutic use , Botswana , Mycobacterium tuberculosis/genetics , Tuberculosis, Multidrug-Resistant/diagnosis , Tuberculosis, Multidrug-Resistant/drug therapy , Tuberculosis/diagnosis , Drug Resistance, Bacterial , Sensitivity and Specificity , Antibiotics, Antitubercular/pharmacology , Antibiotics, Antitubercular/therapeutic use
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