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1.
Sci Rep ; 10(1): 6561, 2020 04 16.
Article in English | MEDLINE | ID: mdl-32300128

ABSTRACT

X-ray Talbot-Lau interferometry is one of the x-ray phase imaging methods that has high sensitivity in depicting soft tissues. Unlike earlier x-ray phase imaging methods that required particular types of x-ray sources, such as a synchrotron or a micro-focus x-ray tube, x-ray Talbot-Lau interferometry enables to perform clinical x-ray phase imaging using a conventional x-ray source with a relatively compact configuration. We developed an apparatus to depict cartilage in the metacarpophalangeal joints of the hands. In addition, we examined the apparatus performance by applying it to healthy volunteers and patients with rheumatoid arthritis (RA). Cartilage deformation, which is thought to be a precursor of destruction of the joints, was successfully depicted by the apparatus, suggesting a potential early diagnosis of RA.


Subject(s)
Arthritis, Rheumatoid/diagnostic imaging , Cartilage/diagnostic imaging , Imaging, Three-Dimensional , Interferometry , Adult , Aged , Aged, 80 and over , Arthritis, Rheumatoid/pathology , Cartilage/pathology , Case-Control Studies , Female , Humans , Joints/diagnostic imaging , Joints/pathology , Male , Middle Aged , X-Rays , Young Adult
2.
Philos Trans A Math Phys Eng Sci ; 372(2010): 20130023, 2014 Mar 06.
Article in English | MEDLINE | ID: mdl-24470409

ABSTRACT

With the aim of clinical applications of X-ray phase imaging based on Talbot-Lau-type grating interferometry to joint diseases and breast cancer, machines employing a conventional X-ray generator have been developed and installed in hospitals. The machine operation especially for diagnosing rheumatoid arthritis is described, which relies on the fact that cartilage in finger joints can be depicted with a dose of several milligray. The palm of a volunteer observed with 19 s exposure (total scan time: 32 s) is reported with a depicted cartilage feature in joints. This machine is now dedicated for clinical research with patients.


Subject(s)
Hospitals , Radiography/instrumentation , Synchrotrons , Humans , Interferometry , Pilot Projects , Radiation Dosage
3.
Anat Sci Int ; 89(2): 95-100, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24081505

ABSTRACT

Conventional X-ray absorption contrast imaging does not depict soft tissues, such as cartilage, in sufficient detail. For visualization of the soft tissues, X-ray phase-contrast imaging is more sensitive than absorption-contrast imaging. The basic concept of the X-ray phase-contrast imaging used in this study is similar to that of differential interference contrast (Nomarski) microscopy. We applied Talbot-Lau X-ray interferometry to visualize the joint structures in the right hand and knee of a donated cadaver. This imaging system simultaneously produced three different types of images: an absorption image, a differential phase image, and a visibility image. The interface between the articular cartilage of the metacarpo-phalangeal joint and fluid or the bony cortex was clearly demonstrated on the differential phase image, whereas this interface was unclear on the absorption image. Within the knee joint, the surface of the articular cartilage was demonstrated both on the differential phase and visibility images; the medial collateral ligament and medial meniscus were also visualized successfully. These results are clinically significant for the diagnosis and therapeutic estimation of rheumatoid arthritis and related joint diseases. This feasibility study on the clinical application of this imaging tool was a collaborative effort of researchers in the fields of physics, radiology, and gross anatomy.


Subject(s)
Arthrography/methods , Humans , Microscopy, Phase-Contrast
4.
Z Med Phys ; 23(3): 222-7, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23219283

ABSTRACT

We developed an X-ray phase imaging system based on Talbot-Lau interferometry and studied its feasibility for clinical diagnoses of joint diseases. The system consists of three X-ray gratings, a conventional X-ray tube, an object holder, an X-ray image sensor, and a computer for image processing. The joints of human cadavers and healthy volunteers were imaged, and the results indicated sufficient sensitivity to cartilage, suggesting medical significance.


Subject(s)
Arthrography/instrumentation , Finger Joint/diagnostic imaging , Interferometry/instrumentation , Refractometry/instrumentation , Tomography, X-Ray Computed/instrumentation , X-Ray Diffraction/instrumentation , Cadaver , Equipment Design , Equipment Failure Analysis , Feasibility Studies , Humans , Reproducibility of Results , Sensitivity and Specificity
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