Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Jpn J Infect Dis ; 62(3): 173-6, 2009 May.
Article in English | MEDLINE | ID: mdl-19468174

ABSTRACT

In this study, the efficacy and safety of assisted reproduction techniques with the sperm-washing method and nested PCR assay were evaluated in HIV-1-discordant couples, as many HIV-1-positive people of reproductive age are getting married and wish to have children safely. Twenty-seven HIV-1-discordant couples (husband, positive; wife, negative) were enrolled in this study. The spermatozoa were separated from semen samples by density gradient centrifugation and the swim-up method. HIV-1 RNA and proviral DNA were checked using nested PCR with a detection limit of one copy before fertilization and before embryo transfer. Clinical outcomes were compared with those of matched control couples. Thirty-eight cycles of in vitro fertilization or intracytoplasmic sperm injection were performed in HIV-1-discordant couples, where the pregnancy rates per embryo transfer and per couple were 60.6 and 63.0%, respectively. These rates were significantly higher than those in control couples (P<0.05). Furthermore, all of the females and babies remained HIV-1 negative throughout the study period. Our data strongly suggest that this technique will allow HIV-1-discordant couples to conceive more safely and effectively.


Subject(s)
HIV Infections/prevention & control , HIV-1/isolation & purification , Polymerase Chain Reaction , Reproductive Techniques, Assisted , Spermatozoa/virology , Adult , Chi-Square Distribution , Female , Fertilization in Vitro/methods , HIV Infections/transmission , HIV Infections/virology , Humans , Japan , Male , Pregnancy , Pregnancy Rate , Specimen Handling , Sperm Injections, Intracytoplasmic/methods
2.
Gynecol Obstet Invest ; 53(4): 243-6, 2002.
Article in English | MEDLINE | ID: mdl-12186993

ABSTRACT

Twin-to-twin transfusion syndrome (TTTS) is a severe complication of monochorionic twin pregnancies, with high perinatal loss and significant morbidity. The etiology of this syndrome remains unclear. Hyperreactio luteinalis is a rare benign condition characterized by maternal ovarian enlargement due to theca lutein cysts. We present 4 cases of hyperreactio luteinalis associated with severe TTTS. We detected maternal ovarian enlargement by prenatal ultrasonography in 2 cases, at the cesarean section in 1 case, and postpartum in 1 case. Three cases showed hydrops fetalis and all cases showed congestive cardiac failure. Serial amnioreduction was performed in all cases, and regression of hydrops fetalis and maternal ovarian enlargement occurred in 1 case. These cases suggest that the pathophysiology of TTTS is closely related to the etiology of hyperreactio luteinalis.


Subject(s)
Fetofetal Transfusion/diagnostic imaging , Hydrops Fetalis/diagnostic imaging , Ovarian Hyperstimulation Syndrome/diagnostic imaging , Pregnancy Complications/diagnostic imaging , Pregnancy, Multiple , Adult , Cesarean Section , Female , Fetal Death , Fetofetal Transfusion/complications , Follow-Up Studies , Humans , Hydrops Fetalis/complications , Infant, Newborn , Ovarian Hyperstimulation Syndrome/complications , Pregnancy , Pregnancy Outcome , Retrospective Studies , Sampling Studies , Twins , Ultrasonography, Prenatal
SELECTION OF CITATIONS
SEARCH DETAIL
...