Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 31
Filter
Add more filters










Publication year range
1.
Bull Exp Biol Med ; 163(3): 293-295, 2017 Jul.
Article in English | MEDLINE | ID: mdl-28744641

ABSTRACT

The effects of chronic intranasal administration of 300 nmol/kg obestatin and its fragment FNAP-NH2 on behavioral activity and nociceptive threshold were examined in male Wistar rats with normal body weight or alimentary obesity. In normal rats, obestatin produced no effect on behavior and nociception, whereas FNAP-NH2 fragment enhanced risk-taking behavior. Rats with excess body weight demonstrated less pronounced risk-taking behavior and elevated nociceptive threshold in comparison with normal animals, but these differences were abolished by chronic administration of FNAP-NH2.


Subject(s)
Nociception/drug effects , Oligopeptides/pharmacology , Pain Threshold/drug effects , Peptide Hormones/pharmacology , Administration, Intranasal , Amino Acid Sequence , Animals , Anxiety/pathology , Anxiety/physiopathology , Body Weight , Eating/physiology , Male , Nociception/physiology , Obesity/pathology , Obesity/physiopathology , Pain Threshold/psychology , Rats , Rats, Wistar , Risk-Taking
2.
Bull Exp Biol Med ; 161(2): 218-20, 2016 Jun.
Article in English | MEDLINE | ID: mdl-27383154

ABSTRACT

Single administration of the obestatin fragment 1-4 (300 nmol/kg) to male Wistar rats produced a significant weight loss in male rats on observation days 5-8, while in female rats only on day 8. In addition, males demonstrated decreased risk factor in the elevated plus-maze test, but no effect of the preparation on behavior of female rats was revealed. Obestatin fragment 1-4 had no effect on corticosterone level 1 week after single administration in both females and male rats.


Subject(s)
Anti-Obesity Agents/pharmacology , Oligopeptides/pharmacology , Animals , Corticosterone/blood , Female , Male , Maze Learning , Rats, Wistar , Risk-Taking , Stress, Psychological/blood
4.
Bull Exp Biol Med ; 155(2): 175-8, 2013 Jun.
Article in English | MEDLINE | ID: mdl-24130982

ABSTRACT

We studied the effects of the anorexigenic peptide obestatin on the coagulation system and blood rheology (by the parameters of platelet aggregation and osmotic resistance of erythrocytes) in vitro and in vivo. Obestatin inhibited in vitro platelet aggregation in the entire dose range and reduced osmotic resistance of erythrocytes in all doses except 300 nmol/kg (obestatin in a dose of 300 nmol/kg had no effect on this parameter). Similar to the results of in vitro experiments, intranasal, intraperitoneal, and subcutaneous administration of obestatin in a dose of 300 nmol/kg inhibited platelet aggregation and had no effect on the osmotic resistance of erythrocytes.


Subject(s)
Osmotic Pressure/drug effects , Peptide Hormones/metabolism , Platelet Aggregation/drug effects , Adenosine Diphosphate/metabolism , Animals , Appetite/drug effects , Blood Coagulation/drug effects , Erythrocytes/drug effects , Erythrocytes/metabolism , Male , Nitric Oxide/biosynthesis , Rats
6.
Izv Akad Nauk Ser Biol ; (5): 529-39, 2012.
Article in Russian | MEDLINE | ID: mdl-23136741

ABSTRACT

This paper considers the transgenerational effects of prenatal stress of different etiology. The impacts of stress factors on the biochemical and morphofunctional parameters of life of the mother, fetus, and offspring in the first and subsequent generations (F1-F4) are estimated. Particular attention is paid to assessing changes in the parameters of physical development, the state of the hypothalamic-pituitary-adrenal axis, proinflammatory status, behavioral indicators, cognitive performance, and vegetative balance in the post-stress period. Contemporary concepts of possible mechanisms of transgenerational transmission of the effects of prenatal stress are considered.


Subject(s)
Hypothalamo-Hypophyseal System/physiopathology , Pituitary-Adrenal System/physiopathology , Prenatal Exposure Delayed Effects/physiopathology , Stress, Physiological , Animals , Female , Humans , Hypothalamo-Hypophyseal System/metabolism , Hypothalamo-Hypophyseal System/pathology , Pituitary-Adrenal System/metabolism , Pituitary-Adrenal System/pathology , Pregnancy , Prenatal Exposure Delayed Effects/metabolism , Prenatal Exposure Delayed Effects/pathology
7.
Ross Fiziol Zh Im I M Sechenova ; 98(3): 331-41, 2012 Mar.
Article in Russian | MEDLINE | ID: mdl-22645942

ABSTRACT

The aim of the present study was to investigate the effects of acute hypobaric hypoxia in early organogenesis on three following generations including pregnant females (FO) and two generations of their posterity (F1 and F2). Animals of all generations mentioned above demonstrated marked changes in motor and exploratory activity as well as in anxiety level while the litter of F1 and F2 generations showed also changes in learning ability. Besides, acute hypobaric hypoxia interfered in maternal behavior of females of the FO and F1 generations. The revealed changes kept till pubertal period. Possible mechanisms of gestational stress influence are discussed.


Subject(s)
Behavior, Animal/physiology , Fetal Hypoxia/physiopathology , Organogenesis/physiology , Prenatal Exposure Delayed Effects/physiopathology , Animals , Female , Fetal Hypoxia/genetics , Male , Motor Activity/genetics , Motor Activity/physiology , Organogenesis/genetics , Pregnancy , Prenatal Exposure Delayed Effects/genetics , Rats
8.
Bull Exp Biol Med ; 151(6): 667-70, 2011 Oct.
Article in English | MEDLINE | ID: mdl-22485203

ABSTRACT

We studied changes in the autonomic balance of heart regulation (by the parameters of heart rate variability) in non-pregnant female rats and rats on the days 10-11 of pregnancy on the next day after stress provoked by acute hypobaric hypoxia, intermittent normobaric hypoxia, or immobilization. The same parameters were assessed in 36-day-old offspring. In non-pregnant rats, the intermittent hypoxia resulted in a shift of the autonomic balance of heart regulation towards activation of the parasympathetic nervous system; in pregnant females, immobilization led to a shift of the autonomic balance towards the sympathetic nervous system. In the offspring, the changes also depended on the type of stress.


Subject(s)
Heart Rate/physiology , Organogenesis/physiology , Stress, Physiological/physiology , Animals , Electrocardiography , Female , Hypoxia/physiopathology , Pregnancy , Rats , Restraint, Physical/physiology
9.
Izv Akad Nauk Ser Biol ; (1): 54-9, 2010.
Article in Russian | MEDLINE | ID: mdl-20235429

ABSTRACT

This study analyses the spontaneous behavior and anxiety-phobic status of mature rats that were subjected to antenatal intermittent hypoxia during the early stages of organogenesis. Antenatal intermittent hypoxia caused a decrease of motor activity as well as an enhanced anxiety level in rats of both sexes, while males appeared to be more sensitive to hypoxic influence. The effects of single antenatal intermittent hypoxia were more expressed than those of double exposure.


Subject(s)
Anxiety/physiopathology , Behavior, Animal , Hypoxia/physiopathology , Motor Activity , Organogenesis , Prenatal Exposure Delayed Effects/physiopathology , Animals , Anxiety/etiology , Female , Hypoxia/complications , Male , Pregnancy , Prenatal Exposure Delayed Effects/etiology , Rats , Sex Characteristics
10.
Izv Akad Nauk Ser Biol ; (3): 365-8, 2008.
Article in Russian | MEDLINE | ID: mdl-18663974

ABSTRACT

The influence of antenatal intermittent normobaric hypoxia during early organogenesis (days 9-10 of intrauterine development) on the physical development, vegetative balance, and antioxidant defense system of 60-day-old rats was studied. Antenatal exposure to intermittent hypoxia resulted in the impaired physical development of all offspring during the early 15-day postnatal period and caused changes in the vegetative balance of heart regulation, which were differently directed in males and females. Moreover, females that survived antenatal hypoxia had a decreased superoxide dismutase activity in the brain, compared to that in the control rats.


Subject(s)
Brain/physiopathology , Heart/physiopathology , Hypoxia/physiopathology , Organogenesis , Prenatal Exposure Delayed Effects/physiopathology , Animals , Animals, Newborn , Antioxidants/metabolism , Brain/embryology , Female , Heart/embryology , Hypoxia/metabolism , Male , Pregnancy , Prenatal Exposure Delayed Effects/metabolism , Rats , Sex Characteristics , Superoxide Dismutase/metabolism
11.
Bull Exp Biol Med ; 146(4): 385-7, 2008 Oct.
Article in English | MEDLINE | ID: mdl-19489302

ABSTRACT

We studied the effect of acute hypobaric hypoxia in early organogenesis on physiological and behavioral parameters of second-generation albino rats. Antenatal acute hypoxia was followed by physical and sexual retardation, increase in the mortality rate, and behavioral changes in second-generation animals (hypoactivity of males and females on day 22 of life and hyperactivity of males on day 57 of life). Second-generation animals exhibited no gender differences in body weight and horizontal and vertical locomotor activity.


Subject(s)
Hypoxia/physiopathology , Organogenesis/physiology , Prenatal Exposure Delayed Effects , Animals , Animals, Newborn , Behavior, Animal , Female , Male , Motor Activity , Pregnancy , Rats , Sex Factors
12.
Izv Akad Nauk Ser Biol ; (4): 476-81, 2006.
Article in Russian | MEDLINE | ID: mdl-17022480

ABSTRACT

The survival rate, physical development, and spontaneous behavior has been evaluated in pups of albino rats exposed to acute hypobaric hypoxia on the 9-10th day of gestation corresponding to the onset of organogenesis. Prenatal hypoxia increased the mortality among the offspring, delayed their physical development, and affected their spontaneous behavior up to the age of 2 months. The females exposed to intrauterine hypoxia proved to be more sensitive to hypoxia than males.


Subject(s)
Behavior, Animal , Hypoxia/complications , Pregnancy Complications , Prenatal Exposure Delayed Effects , Animals , Animals, Newborn , Female , Fetal Hypoxia , Male , Organogenesis , Pregnancy , Rats , Sex Factors
13.
Bull Exp Biol Med ; 142(1): 32-4, 2006 Jul.
Article in English, Russian | MEDLINE | ID: mdl-17369896

ABSTRACT

Physical development, spontaneous behavior, and training capacity were evaluated in adult progeny of albino rats exposed to acute hypobaric hypoxia on days 9-10 of gestation, corresponding to the early organogenesis period. Prenatal hypoxia caused delayed behavioral disorders, which were more pronounced in females born from mothers with low resistance to hypoxia. Therapeutic intranasal administration of Pro-Gly-Pro peptide in a dose of 1 mg/kg to rat pups on days 13-15 of life completely prevented the negative consequences of acute prenatal hypoxia in adult females and leveled virtually all negative consequences, except delayed physical development, in males.


Subject(s)
Hypoxia/complications , Hypoxia/physiopathology , Mental Disorders/drug therapy , Oligopeptides/therapeutic use , Prenatal Exposure Delayed Effects/physiopathology , Proline/analogs & derivatives , Animals , Female , Male , Mental Disorders/etiology , Pregnancy , Proline/therapeutic use , Rats , Risk-Taking
14.
Bull Exp Biol Med ; 142(5): 543-5, 2006 Nov.
Article in English | MEDLINE | ID: mdl-17415485

ABSTRACT

Cardiac activity in rats during the postnatal period was studied in vitro and in vivo after exposure of rat pups to antenatal acute hypobaric hypoxia at the stage of organogenesis (day 9-10 of gestation). Cultured cardiomyocytes from rat pups exposed to antenatal hypoxia were characterized by increased rate of contractions and decreased reactivity to norepinephrine. Heart rate elevation, predominance of sympathetic influences on cardiac activity, and significant increase in norepinephrine concentration in the cerebral cortex were found in freely moving animals exposed to antenatal hypoxia. Our results indicate that hypoxia at the stage of organogenesis modulated cardiac activity during the postnatal period, which manifested at the level of effector structures in the heart and activity of regulatory systems.


Subject(s)
Hypoxia/physiopathology , Myocytes, Cardiac/physiology , Norepinephrine/physiology , Prenatal Exposure Delayed Effects , Animals , Animals, Newborn , Cells, Cultured , Cerebral Cortex/metabolism , Female , Fetal Hypoxia/physiopathology , Heart Rate/drug effects , Myocardial Contraction/drug effects , Myocytes, Cardiac/drug effects , Pregnancy , Pregnancy Complications , Rats
15.
Ross Fiziol Zh Im I M Sechenova ; 92(9): 1085-91, 2006 Sep.
Article in Russian | MEDLINE | ID: mdl-17290876

ABSTRACT

The aim of the present study was to compare the survival, physical development and spontaneous behavior of rat pups born from white rats subjected to acute hypobaric hypoxia on the 3rd-5th days of gestation (progestation) period or on the 9-10th day of gestation (period of early organogenesis). It was shown that the delayed effects of progestation hypoxia were less expressed than those following acute hypoxia modeled in the early organogenesis. In latter case, hypoxia led to the increased mortality among rat pups of both sexes while hypoxia-induced delay in physical development and changes in spontaneous behavior and anxiety level were registered up to the 57th day of postnatal period.


Subject(s)
Behavior, Animal , Hypoxia/complications , Maternal Exposure , Organogenesis , Prenatal Exposure Delayed Effects , Animals , Female , Fetal Hypoxia , Gestational Age , Male , Maternal-Fetal Exchange , Pregnancy , Rats , Sex Factors
16.
Bull Exp Biol Med ; 139(2): 180-2, 2005 Feb.
Article in English, Russian | MEDLINE | ID: mdl-16027800

ABSTRACT

Changes in ECG parameters were studied in pregnant rats exposed to acute hypobaric hypoxia during the period of organogenesis (gestation days 9 to 10). Rats with low, medium, and high tolerance to hypoxia exhibited pronounced autonomic nervous system imbalance, which become apparent as a loss of correlation between various parameters of ECG signals recorded at rest and during exposure to some stress factors existing under normal conditions.


Subject(s)
Autonomic Nervous System/physiopathology , Heart/innervation , Hypoxia/physiopathology , Organogenesis , Animals , Electrocardiography , Female , Pregnancy , Rats , Rats, Inbred Strains , Stress, Physiological/physiopathology
17.
Ross Fiziol Zh Im I M Sechenova ; 91(2): 152-7, 2005 Feb.
Article in Russian | MEDLINE | ID: mdl-15835538

ABSTRACT

The effects of acute hypobaric hypoxia on the stages of progestation or beginning of organogenesis on biogenic amines levels in brain stem and cerebral cortex of their mature offspring as well as on their behavior, were investigated. It was shown that acute hypoxia applied in the period of embryonic organogenesis resulted in severe delayed changes in offspring spontaneous behavior and led to marked changes of biogenic amine levels, particularly expressed for dopaminergic system. Females subjected to antenatal hypoxia happened to be more sensitive to its influences than males.


Subject(s)
Behavior, Animal/physiology , Biogenic Monoamines/metabolism , Brain/metabolism , Embryonic Development/physiology , Hypoxia/physiopathology , Pregnancy Complications/physiopathology , Acute Disease , Animals , Animals, Newborn , Brain/growth & development , Female , Gestational Age , Hypoxia/complications , Hypoxia/metabolism , Male , Pregnancy , Pregnancy Complications/metabolism , Rats , Sex Factors
19.
Neurosci Behav Physiol ; 33(6): 607-11, 2003 Jul.
Article in English | MEDLINE | ID: mdl-14552554

ABSTRACT

Ante- and postnatal hypoxia significantly worsened the postnatal development of animals. The posthypoxic behavioral model included hyperactivity and decreased learning ability, these being typical manifestations of attention deficit disorder. A peptide constellation prevented and significantly improved posthypoxic postnatal development and eliminated the majority of negative behavioral changes.


Subject(s)
Adrenocorticotropic Hormone/analogs & derivatives , Brain/embryology , Brain/metabolism , Hypoxia/embryology , Hypoxia/metabolism , Neuroprotective Agents/administration & dosage , Neuroprotective Agents/metabolism , Prenatal Exposure Delayed Effects , Adrenocorticotropic Hormone/metabolism , Animals , Brain/growth & development , Drug Therapy, Combination , Endorphins/administration & dosage , Endorphins/metabolism , Female , Humans , Hypoxia/prevention & control , Peptide Fragments/administration & dosage , Peptide Fragments/metabolism , Pregnancy , Pregnancy Complications/metabolism , Rats , Thyrotropin-Releasing Hormone/administration & dosage , Thyrotropin-Releasing Hormone/metabolism
20.
Bull Exp Biol Med ; 135(6): 526-9, 2003 Jun.
Article in English | MEDLINE | ID: mdl-12937663

ABSTRACT

We studied immediate and delayed changes in ECG in female albino rats subjected to acute hypobaric hypoxia on days 4-5 of pregnancy and evaluated the possibility of correction of hypoxia-produced disturbances with some peptides. Acute hypoxia lengthened the mean RR interval, increased heart rate variability, and decreased the monotony index. Hypoxia induced considerable changes in the structure of ECG that reflected the development of arrhythmias and conduction disturbances. These changes in ECG persisted during the posthypoxic period. Intranasal administration of heptapeptides Semax and beta-casomorphin-7 to pregnant females promoted recovery from acute hypoxia and normalized ECG in the posthypoxic period.


Subject(s)
Adrenocorticotropic Hormone/analogs & derivatives , Adrenocorticotropic Hormone/metabolism , Electrocardiography , Endorphins/metabolism , Hypoxia/metabolism , Peptide Fragments/metabolism , Animals , Atmospheric Pressure , Female , Heart Rate/physiology , Myocardium/metabolism , Pregnancy , Rats
SELECTION OF CITATIONS
SEARCH DETAIL
...