ABSTRACT
Two new methods for elimination of bronchial fistulas in postresectional empyemas were tested in 40 patients. The most effective procedure was transbronchial diathermocoagulation of the draining (fistular) bronchus, with a full clinical effect being in 100% of patients), and selective foam rubber obturation in 80%.
Subject(s)
Bronchial Fistula/therapy , Electrocoagulation , Empyema, Pleural/therapy , Postoperative Complications/therapy , Tuberculosis, Pulmonary/surgery , Adult , Bronchial Fistula/surgery , Embolization, Therapeutic , Empyema, Pleural/surgery , Follow-Up Studies , Humans , Middle Aged , Postoperative Complications/surgery , Time FactorsABSTRACT
It was shown that a single injection of heparin (250 units/kg) 15 min and 24 h before irradiation potentiated a slight radioprotective effect of cystamine (dichlorohydrate, 170 mg/kg) which was registered after the administration thereof to mice 30 min before irradiation with an absolutely lethal dose at a dose rate of 0.0025 Gy/c.
Subject(s)
Cystamine/therapeutic use , Heparin/therapeutic use , Radiation Injuries, Experimental/prevention & control , Radiation-Protective Agents/therapeutic use , Animals , Drug Synergism , Male , MiceABSTRACT
A single administration of dextransulfate (40 mg/kg, 1-3 days before irradiation), or a double injection of heparin (250 units/kg, 24 hr and 15 min before irradiation) potentiated a weak radioprotective effect of gas hypoxic mixture (GHM-10) on animals exposed to absolutely lethal doses.
Subject(s)
Dextrans/administration & dosage , Heparin/administration & dosage , Nitrogen/administration & dosage , Oxygen/administration & dosage , Radiation-Protective Agents/administration & dosage , Animals , Dextran Sulfate , Drug Evaluation, Preclinical , Drug Synergism , Drug Therapy, Combination , Gamma Rays , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Radiation Injuries, Experimental/prevention & controlABSTRACT
It has been shown that a single intraperitoneal injection of dextran sulfate (molecular weight 500 000, 60 mg/kg) to (CBA X C57BL)F1 mice 1-3 days before irradiation in lethal doses, with the irradiation dosage amounting to 8.10(-3), 3.10(-3) and 8.10(-4) Gy/c, increases the animals' survival rate. The effect of dextran sulfate on the degree of postradiation changes in the blood leukocyte count and in the bone marrow karyocyte count depends on the interval between dextran sulfate injection and irradiation.
Subject(s)
Dextrans , Radiation-Protective Agents , Animals , Dextran Sulfate , Dose-Response Relationship, Radiation , Drug Evaluation, Preclinical , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Radiation Injuries, Experimental/mortality , Radiation Injuries, Experimental/prevention & control , Time FactorsABSTRACT
In experiments on (CBA X C57Bl)F1 mice irradiated with doses of 8-12 Gy a study was made of the effect of a mixture of polyI-polyC (2.5 mg/kg, 2 days before irradiation) and mexamine (30 mg/kg, 5 min before irradiation) on the survival rate of animals and the times of their death. It was shown that polyI-polyC potentiates the protective effect of mexamine not increasing its toxicity. The protective agents used in a combination decrease the "intestinal" death of irradiated animals while used separately fail to produce this effect.
Subject(s)
5-Methoxytryptamine/administration & dosage , Poly I-C/administration & dosage , Radiation-Protective Agents/administration & dosage , Tryptamines/administration & dosage , Animals , Bone Marrow/drug effects , Bone Marrow/radiation effects , Dose-Response Relationship, Radiation , Drug Synergism , Gamma Rays , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBAABSTRACT
It was shown on (CBA X C57Bl)F1 mice that a single intraperitoneal injection of a physiological solution (0.2 ml) reduced the number of haemopoietic stem cells in the bone marrow and increased concurrently the radioresistance of CFU.
Subject(s)
Hematopoietic Stem Cells/drug effects , Sodium Chloride/pharmacology , Animals , Cobalt Radioisotopes , Dose-Response Relationship, Drug , Hematopoietic Stem Cells/radiation effects , Isotonic Solutions , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Time FactorsABSTRACT
Single intraperitoneal administration of dextran sulfate to noninbred mice at a dose of 60 mg/kg 3--24 and 48 hours prior to irradiation in lethal and sublethal doses exerts no radioprotective action. Administration of the drug 24 hours before irradiation increases the intensity of postradiation leukopenia. During irradiation of the animals in a dose of 650 rad dextran sulfate accelerates the recovery of hemopoiesis. With the dose of irradiation being increased up to 750 rad, the drug produces no effect on this parameter.