ABSTRACT
It was demonstrated in experiments on pregnant rats that toxolytic doses of the calcium channel blockers nifedipine, cardiazem (diltiazem) and verapamyl reduce blood pressure, heart rate, and doppler ultrasound velocity in the uterine artery. Toxolytic doses of sensit (fendilin) do not change hemodynamics in pregnant rats.
Subject(s)
Blood Pressure/drug effects , Calcium Channel Blockers/pharmacology , Heart Rate/drug effects , Tocolytic Agents/pharmacology , Uterus/drug effects , Animals , Diltiazem/pharmacology , Dose-Response Relationship, Drug , Female , Fendiline/pharmacology , Nifedipine/pharmacology , Pregnancy , Rats , Rats, Wistar , Regional Blood Flow/drug effects , Uterus/blood supply , Verapamil/pharmacologySubject(s)
Hair/growth & development , Muscles/transplantation , Regeneration , Animals , Male , Muscles/physiology , Rats , Transplantation, AutologousSubject(s)
Muscles/transplantation , Transplantation, Heterologous , Animals , Gerbillinae , Graft Rejection , Male , Muscles/physiology , Rats , RegenerationABSTRACT
In frogs, tortoises and rats autotransplantation of the whole gastrocnemius muscle has been performed into its own bed at sewing the nerve to the autotransplant and at its denervation. Fragments of the skeletal muscles are also transplanted into the brain and into the spinal cord in frogs and rats. By means of light and electron microscopy, restorative processes are studied in the transplanted muscles. Acceleration of histomorphogenesis of the muscular and nervous tissues is stated from the lower toward the higher Vertebrata. When the transplants are deprived of the connection with the nervous system, the cause of the form organization process in all the animals investigated is disturbed, however, the nervous-trophic regulation is of the greatest importance in the mammalia. The experiments reveal mutual regulation of the plastic activity in the nervous and muscular tissues, that becomes more intensive in the course of evolution.